Upside Down, Give me the Handle

NCT02544516 | Completed

• 2 other identifiers: 13081392013-A01294-41
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

In schizophrenia, dislocation of psychic functions involving a loss of contact with reality is frequently found. A fragmentation of motor and sensory perceptions could be held responsible (Fuchs, 2005). However, automatic integration between perception and action is the necessary condition to be in "relationship with the world." Affordance is the experimental link between object perception and actions potentially associated (Gibson (1977, 1979) explored by Stimulus Response Compatibility (SRC) paradigm. The existence of visual motor neurons leads us to postulate that the affordance effect can be assisted by a visuomotor priming of a hand in a position to grasp. With Tucker \& Ellis sensory motor compatibility task, we study the capacity of affordance in schizophrenia, as well as the impact of perceptual motor priming on these affordance effects.

Conditions

Schizophrenic Disorders

Keywords

Schizophrenia; motor and sensory perceptions

Outcome Measures

Primary Outcomes (1)

• response time

  The gain provided by the compatible vs incompatible conditions (ms response time)

  day 1

Study Arms (2)

Patients

EXPERIMENTAL

patients suffering schizophrenic disorders and who will perform cognitive tasks + PANSS+ IQ

Other: cognitive tasks + PANSS+ IQ

control group

ACTIVE COMPARATOR

healthy patients who will perform cognitive tasks

Other: cognitive tasks

Interventions

cognitive tasks + PANSS+ IQ OTHER

Patients will have cognitive tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale, Kay et al., 1987

Patients

cognitive tasks OTHER

Patients will have cognitive tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971),

control group

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• For patients:
• a DSM-IV diagnosis of schizophrenia (men or women),
• no change in antipsychotic medication and clinical status within four weeks prior to the study

You may not qualify if:

• IQ \< 70
• \- Age ≥ 18 years et ≤ 50 years
• History of head trauma,
• neurological disease with cerebral repercussion or not stabilized serious physical illness;
• psychotropic medication,
• disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (1)

CHU de SAINT-ETIENNE

Saint-Etienne, 42000, France

Location

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Catherine MASSOUBRE, MD

  CHU de SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 7, 2015
• First Posted: September 9, 2015
• Study Start: April 1, 2014
• Primary Completion: October 1, 2016
• Study Completion: October 1, 2016
• Last Updated: November 22, 2016

Record last verified: 2016-11

Locations

FR (1)