NCT03245476

Brief Summary

This study aims, by means of a randomized control trial, to investigate which treatment method (corticoid injection + physiotherapy with a focus on manual therapy and home-exercises versus corticosteroid injection + physiotherapy with focus on education and supported home exercises) gives better results on clinically relevant outcomes (range of glenohumeral motion, psychological factors, pain, shoulder function, quality of life) and on parameters derived from arthroscopic glenohumeral investigation by means of MRI. Furthermore, associations between (1) the results on the MRI investigation, (2) the range of glenohumeral motion, (3) shoulder function and pain, and (4) psychological factors will be assessed at different time-points (before and at 6-12-18 and 52 weeks after the first injection).

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2017

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 8, 2017

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 10, 2017

Completed
25 days until next milestone

Study Start

First participant enrolled

September 4, 2017

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 4, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 4, 2019

Completed
Last Updated

August 10, 2017

Status Verified

August 1, 2017

Enrollment Period

2 years

First QC Date

August 8, 2017

Last Update Submit

August 8, 2017

Conditions

Outcome Measures

Primary Outcomes (17)

  • Scapulothoracic, glenohumeral and elbow joint range of motion

    before the first injection with corticosteroids By means of inertial motion sensors, range of motion in the scapulothoracic, glenohumeral and elbow joint will be assessed during functional task performance

    baseline

  • Scapulothoracic, glenohumeral and elbow joint range of motion

    after the first injection with corticosteroids. By means of inertial motion sensors, range of motion in the scapulothoracic, glenohumeral and elbow joint will be assessed during functional task performance

    week 6

  • Scapulothoracic, glenohumeral and elbow joint range of motion

    after the first injection with corticosteroids. By means of inertial motion sensors, range of motion in the scapulothoracic, glenohumeral and elbow joint will be assessed during functional task performance

    week 12

  • Scapulothoracic, glenohumeral and elbow joint range of motion

    after the first injection with corticosteroids. By means of inertial motion sensors, range of motion in the scapulothoracic, glenohumeral and elbow joint will be assessed during functional task performance

    week 18

  • Scapulothoracic, glenohumeral and elbow joint range of motion

    after the first injection with corticosteroids. By means of inertial motion sensors, range of motion in the scapulothoracic, glenohumeral and elbow joint will be assessed during functional task performance

    week 52

  • parameters on arthrographic investigation by means of MRI

    the thickness of the coracohumeral ligament, the capacity of the inferior glenohumeral joint recessus are investigated.

    baseline

  • parameters on arthrographic investigation by means of MRI

    the thickness of the coracohumeral ligament, the capacity of the inferior glenohumeral joint recessus are investigated.

    week 18

  • Disability of the shoulder, elbow and hand questionnaire

    assessment of upper limb function

    baseline

  • Disability of the shoulder, elbow and hand questionnaire

    assessment of upper limb function

    week 6

  • Disability of the shoulder, elbow and hand questionnaire

    assessment of upper limb function

    week 12

  • Disability of the shoulder, elbow and hand questionnaire

    assessment of upper limb function

    week 18

  • Disability of the shoulder, elbow and hand questionnaire

    assessment of upper limb function

    week 52

  • Brief pain inventory

    assessment of current, worst and night pain on a 11 point likert scale

    baseline

  • Brief pain inventory

    assessment of current, worst and night pain on a 11 point likert scale

    week 6

  • Brief pain inventory

    assessment of current, worst and night pain on a 11 point likert scale

    week 12

  • Brief pain inventory

    assessment of current, worst and night pain on a 11 point likert scale

    week 18

  • Brief pain inventory

    assessment of current, worst and night pain on a 11 point likert scale

    week 52

Secondary Outcomes (20)

  • EQ-5D-5L questionnaire

    baseline

  • EQ-5D-5L questionnaire

    week 6

  • EQ-5D-5L questionnaire

    week 12

  • EQ-5D-5L questionnaire

    week 18

  • EQ-5D-5L questionnaire

    week 52

  • +15 more secondary outcomes

Study Arms (2)

manual therapy and home-exercises

ACTIVE COMPARATOR

corticoid injection + physiotherapy with a focus on manual therapy and home-exercises

Other: Physical therapy focus on manual therapy and home-exercises

education and supported home exercises

ACTIVE COMPARATOR

corticosteroid injection + physiotherapy with focus on education and supported home exercises

Other: Physical therapy focus on education and supported home exercises

Interventions

corticoid injection + physiotherapy with a focus on manual therapy and home-exercises

manual therapy and home-exercises

corticosteroid injection + physiotherapy with focus on education and supported home exercises

education and supported home exercises

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • % loss of passive GH external rotation motion, together with motion losses greater than 25% in at least two other GH movements, as compared to the unaffected side
  • the pain accompanying the motion losses has to be present for at least one month. During that month, the pain and mobility deficits have to be stable or get worse

You may not qualify if:

  • bilateral frozen shoulder
  • systemic and/or neurologic disease or a self-reported pathologic condition of the cervical/thoracic region, elbow or wrist/hand

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Jessa Ziekenhuis

Hasselt, 3500, Belgium

Location

MeSH Terms

Conditions

Bursitis

Condition Hierarchy (Ancestors)

Joint DiseasesMusculoskeletal Diseases

Study Officials

  • Liesbet De Baets, dr.

    Hasselt University

    STUDY CHAIR
  • Annick Timmermans, prof. dr.

    Hasselt University

    PRINCIPAL INVESTIGATOR
  • Carl Dierickx, prof. dr.

    Jessa ziekenhuis, Universiteit Hasselt

    STUDY CHAIR

Central Study Contacts

Liesbet De Baets, dr.

CONTACT

Annick Timmermans, prof. dr.

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: corticoid injection + physiotherapy with a focus on manual therapy and home-exercises versus corticosteroid injection + physiotherapy with focus on education and supported home exercises
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
prof. dr.

Study Record Dates

First Submitted

August 8, 2017

First Posted

August 10, 2017

Study Start

September 4, 2017

Primary Completion

September 4, 2019

Study Completion

September 4, 2019

Last Updated

August 10, 2017

Record last verified: 2017-08

Locations