Thrive, a Computerized Cognitive Behavior Therapy Program to Treat Depression

NCT03244878 | Completed

• 1 other identifier: MS033017-FC
• Study Type: interventional
• Target: 464
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates a culturally-modified version of Thrive, a computerized Cognitive Behavior Therapy program to treat depressive symptoms, syndromes, and disorders among rural Montanans. Study participants will be randomized to either a wait-list treatment as usual or the Thrive program. After 8 weeks, the wait-list group will then receive Thrive. The primary assessment measure is the Patient Health Questionnaire-9.

Conditions

Depressive Symptoms

Keywords

Cognitive Behavior Therapy

Outcome Measures

Primary Outcomes (1)

• Patient Health Questionnaire-9

  Clinical measure of depressive symptom severity. Self-reported with a score range from 0 to 3 (not at all to nearly every day)

  2 weeks

Secondary Outcomes (3)

• Generalized Anxiety Disorder-7

  2 weeks

• Work and Social Adjustment Scale

  1 year

• Connor-Davidson Resilience Scale

  1 month

Study Arms (2)

Intervention - Thrive program

EXPERIMENTAL

Participants will receive access to the Thrive program for 8 weeks

Behavioral: Thrive

Wait-list Control

NO INTERVENTION

Participants will have no access to the Thrive program for 8 weeks upon enrollment. They will receive a link to the NIMH website to read about information on depression.

Interventions

Thrive BEHAVIORAL

A interactive computerized program using structured content of cognitive behavior therapy

Intervention - Thrive program

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 18 years or older
• Baseline PHQ-9 score of 5 or greater
• Montana resident
• Regular access to broadband internet (streaming capability)

You may not qualify if:

• No broadband internet access
• Aged 17 years or younger
• Does not have Montana residency
• Baseline PHQ-9 score of \< 5

Sponsors & Collaborators

• Montana State University: lead

Study Sites (1)

Montana State University

Bozeman, Montana, 59717, United States

Location

Related Publications (2)

• Schure M, McCrory B, Tuchscherer Franklin K, Greist J, Weissman RS. Twelve-Month Follow-Up to a Fully Automated Internet-Based Cognitive Behavior Therapy Intervention for Rural Adults With Depression Symptoms: Single-Arm Longitudinal Study. J Med Internet Res. 2020 Oct 2;22(10):e21336. doi: 10.2196/21336.

  PMID: 33006561 DERIVED

• Schure MB, Lindow JC, Greist JH, Nakonezny PA, Bailey SJ, Bryan WL, Byerly MJ. Use of a Fully Automated Internet-Based Cognitive Behavior Therapy Intervention in a Community Population of Adults With Depression Symptoms: Randomized Controlled Trial. J Med Internet Res. 2019 Nov 18;21(11):e14754. doi: 10.2196/14754.

  PMID: 31738173 DERIVED

MeSH Terms

Conditions

Depression

Interventions

Nicotine

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Solanaceous Alkaloids; Alkaloids; Heterocyclic Compounds; Pyridines; Heterocyclic Compounds, 1-Ring

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Participants are randomized to either the wait-list controlled group or intervention group. Intervention period is 8 weeks. Data collection occurs at baseline, 4 weeks, and 8 weeks, with longer-term follow-up assessments.

Study Record Dates

• First Submitted: August 3, 2017
• First Posted: August 10, 2017
• Study Start: May 1, 2017
• Primary Completion: January 31, 2018
• Study Completion: January 31, 2018
• Last Updated: August 14, 2018

Record last verified: 2018-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)