Motor Evoked Potential in the Affected Upper Limb Predicts the Potential of Motor Recovery in Subacute Stroke Patients

NCT03243318 | Completed DMC FDA Device

• 1 other identifier: KHMEPsUL2017
• Study Type: observational
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

Stroke is the third common cause of adult disability in dveloped countries. Early identification of the potential for motor recovery is important to avoid 'learned disuse' and to initiate appropriate therapy with achievable goals. The current cohort study focuses on those patients with SAFE \<8 and using motor evoked potentials (MEPs) to improve on prognostication of upper limb motor recovery among subacute stroke patients in a local stroke population.

Conditions

Stroke, Subacute

Outcome Measures

Primary Outcomes (1)

• Action Research Arm Test

  Upper limb functional test

  Change of Baseline Action Research Arm Test at 12 weeks post-stroke

Study Arms (2)

Presence of motor evoked potentials

Those patients with Shoulder Abduction and Finger Extension (SAFE) score \<8/10 with the presence of motor evoked potentials elicited by TMS over the ipsilesional motor cortex

Diagnostic Test: MEPs induced by TMS

absence of motor evoked potentials

Those patients with Shoulder Abduction and Finger Extension (SAFE) score \<8/10 with the absence of motor evoked potentials elicited by TMS over the ipsilesional motor cortex

Diagnostic Test: MEPs induced by TMS

Interventions

MEPs induced by TMS DIAGNOSTIC_TEST

Using TMS induced MEPs over motor cortex of the affected side to predict motor recovery potentials

Presence of motor evoked potentials; absence of motor evoked potentials

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Subacute stroke patients

You may qualify if:

• First stroke with hemiparesis or hemiplegia with SAFE \<8

You may not qualify if:

• contra-indication to TMS or MRI, history of seizure, pregnancy and mentally unfit to understand the consent

Sponsors & Collaborators

• Hospital Authority, Hong Kong: lead

Study Sites (1)

Department of Rehabilitation, Kowloon Hospital

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: August 4, 2017
• First Posted: August 9, 2017
• Study Start: October 11, 2017
• Primary Completion: October 31, 2021
• Study Completion: November 30, 2021
• Last Updated: May 26, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)