Computed Tomography in Gastrointestinal Bleeding

NCT03243240 | Unknown

• 1 other identifier: CT git bleeding
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

Gastrointestinal bleeding represents a serious clinical problem and a common cause of hospitalisation with a mortality rate of 6-10% for upper Gastrointestinal bleeding and of 4% for lower Gastrointestinal bleeding requires a multidisciplinary approach involving gastroenterologists, endoscopists, surgeons and radiologists. Gastrointestinal bleeding is self-limited in 80% of cases requiring only supportive measures. However, the persistence of bleeding represents a diagnostic challenge to locate the site of bleeding especially in severe bleeding and to determine, if possible its cause. This will allow to select the most appropriate therapeutic approach in order to reduce the morbidity and mortality, the length of hospitalisation and the transfusion requirements. Current diagnostic algorithms vary widely from institution to institution and from clinician to clinician. Imaging modalities remain the mainstay of the diagnostic approach. They include endoscopy, video capsule, radionuclide imaging, catheter angiography and multidetector computed tomography imaging. In recent years, Multidetector computed tomography has emerged as a promising technology to evaluate Gastrointestinal bleeding. The modality's ease of use and rapid results favour its use in any emergent situation. In addition, today's high-speed, narrow collimation multi-detector technology allows a large coverage area with minimal motion artifacts, with the ability to capture both arterial and venous phase with ease. Multidetector computed tomography is being increasingly used as this is a widely available, non-invasive and fast diagnostic technique that allows for visualisation of the entire intestinal tract and its lesions, the identification of vascularity and possible vascular abnormalities.

Conditions

Gastrointestinal Bleeding

Outcome Measures

Primary Outcomes (1)

• Role of triphasic computed tomography imaging in detection of acute non variceal gastrointestinal tract bleeding

  Number of 30 patients with acute gastrointestinal bleeding will undergo multislice computed tomography angiography with 16 multislice computed tomography scanner with dose 1-2ml/kg body weight contrast media and the study will be revised to detect the contrast extravasation which means active bleeding, and will detect the cause of bleeding such as tumor, aneurysm, arteriovenous malformation....and confirmation of these results will be done by angiographic intervention and embolization of the bleeding vessel

  one year

Interventions

mutlidetector computed tomography DIAGNOSTIC_TEST

Multidetector computed tomography angiography with 16- MSCT scanner, medical system bright speed. Our protocol will include non-enhanced scanning then perform a triphasic angiography that includes arterial, portal and venous phases to detect acute gastrointestinal bleeding. Images will be acquired with the following parameters slice thickness 5mm for the unenhanced phase and 1.25mm for the arterial phase and porto-venous phases

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A number of 30 Patients with Acute Gastrointestinal bleeding will be included in the study. This study will be performed in Radio diagnostic department in Assiut University Hospital. We will perform multi detector computed tomography angiography with 16 or 64 multi slice computed tomography scanner. our protocol will include non enhanced scanning then perform triphasic angiography that include arterial , portal and venous phases to detect gastrointestinal bleeding.

You may qualify if:

• patients with unexplained non variceal gastrointestinal bleeding

You may not qualify if:

• patients with impaired renal functions or terminal liver failure. pregnancy. patients known to be sensitive to contrast media. cases diagnosed endoscopically as variceal bleeding.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (1)

• Geffroy Y, Rodallec MH, Boulay-Coletta I, Julles MC, Ridereau-Zins C, Zins M. Multidetector CT angiography in acute gastrointestinal bleeding: why, when, and how. Radiographics. 2011 May-Jun;31(3):E35-46. doi: 10.1148/rg.313105206.

  PMID: 21721196 BACKGROUND

MeSH Terms

Conditions

Gastrointestinal Hemorrhage

Condition Hierarchy (Ancestors)

Gastrointestinal Diseases; Digestive System Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Ghada Abdelsabour, resident

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hany Mohammed, Professor

CONTACT

01119159500; Hany.rad@yahoo.com

Omran Khodary, Lecturer

CONTACT

01117298484; Omranshow@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator

Study Record Dates

• First Submitted: July 10, 2017
• First Posted: August 8, 2017
• Study Start: September 1, 2017
• Primary Completion: August 1, 2018
• Study Completion: December 1, 2018
• Last Updated: August 8, 2017

Record last verified: 2017-08