Endometriosis Impact on Oocyte Quality

NCT03241329 | Completed

• 1 other identifier: 2017-A01163-50
• Study Type: observational
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the impact of endometriosis on folliculogenesis and oocyte quality. To do so, a metabolomic approach will be conducted in order to analyze the follicular fluid. This evaluation will be completed by a transcriptomic analysis from the cumulus cells of the oocyte. The normal and pathological oocyte cohort after controlled ovarian stimulation will be also characterized by identifying the oocyte leading to live birth.

Conditions

Endometriosis

Keywords

Endometriosis; Metabolomics; Transcriptomics; Follicular fluid; Cumulus cells; Oocyte quality

Outcome Measures

Primary Outcomes (2)

• Metabolic profile

  Identification of a possible particular metabolomic profile from the follicular fluid in endometriosis

  2 years

• Transcriptomic profile

  Identification of a possible particular transcriptomic profile from the cumulus cells in endometriosis

  2 years

Secondary Outcomes (1)

• Oocyte characterization

  2 years

Study Arms (2)

Case : endometriosis

Infertile patients with endometriosis that is the only cause of their infertility

Control : tubal factor

infertile patients with tubal factor that is the only cause of their infertility

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients enrolled in a ART (assisted reproductive technology) attempt in the IVF unit of the center.

You may qualify if:

• Group 1: case
• a. Womens with endometriosis i. Deep endometriosis without ovarian localisation ii. Deep endometriosis associated with ovarian localisation iii. Isolated ovarian localisation b. Male partner with normal sperm parameters Group 2 : control
• Womens with isolated tubal factor
• Male partner with normal sperm parameters

You may not qualify if:

• Other pathologies responsible for female infertility
• Altered sperm parameters
• Male or female viral risk
• Oocyte or sperm donation

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead
• URC-CIC Paris Descartes Necker Cochin: collaborator

Study Sites (1)

Hôpital Cochin-Port Royal

Paris, Paris, 75014, France

Location

Related Publications (1)

• Pocate-Cheriet K, Santulli P, Kateb F, Bourdon M, Maignien C, Batteux F, Chouzenoux S, Patrat C, Wolf JP, Bertho G, Chapron C. The follicular fluid metabolome differs according to the endometriosis phenotype. Reprod Biomed Online. 2020 Dec;41(6):1023-1037. doi: 10.1016/j.rbmo.2020.09.002. Epub 2020 Sep 4.

  PMID: 33046374 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

1. Samples without DNA : follicular fluids 2. Samples with DNA : cumulus cells from which RNA will be extracted in order to perform transcriptomics analysis

MeSH Terms

Conditions

Endometriosis

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Officials

• Khaled POCATE-CHERIET, MD, PhD

  Assistance Publique - Hôpitaux de Paris

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 2, 2017
• First Posted: August 7, 2017
• Study Start: February 26, 2018
• Primary Completion: July 12, 2018
• Study Completion: July 12, 2018
• Last Updated: September 11, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)