Metabolic and Functional Impact of Various Breakfast Models

NCT03240757 | Completed

• 1 other identifier: Colazioni/1
• Study Type: interventional
• Target: 19
• Locations: 0 countries
• Sites: N/A

Brief Summary

In the present study the investigators compared the hormonal and metabolic effects of three meal loads very popular among Italian eating habits, both in the resting- and exercising state. Given the lack of time is considered a common barrier to exercise adherence, we wanted to identify a low dose of exercise capable to produce health benefits in the post-absorptive status elicited by three commonly consumed meal-models in Mediterranean countries. To this end, healthy young volunteers firstly underwent an oral glucose tolerance test (OGTT) and three meal tolerance tests. Secondly, in an extra set of experiments, subjects cycled at low intensity for the last 20 minutes of the same glucose/meal tolerance test. Glycemia, insulinemia, ghrelinemia, lipidemia, and satiety were measured throughout OGTT and each test-meal load.

Conditions

Metabolism and Nutrition Disorder

Keywords

meal absorption; exercise; energy balance; lipolysis

Outcome Measures

Primary Outcomes (4)

• Plasma glucose responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.

  Postprandial glycemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.

  The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).

• Plasma insulin responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.

  Postprandial insulinemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.

  The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).

• Plasma ghrelin responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.

  Postprandial ghrelinemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.

  The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).

• Plasma free fatty acids (FFA) responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.

  Postprandial plasma FFA responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.

  The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).

Study Arms (2)

Breakfast without exercise

ACTIVE COMPARATOR

Each subject of the same arm underwent 2 interventions: breakfast with/without exercise

Dietary Supplement: Breakfast

Breakfast with exercise

EXPERIMENTAL

Each subject of the same arm underwent 2 interventions: breakfast with/without exercise

Dietary Supplement: Breakfast; Other: exercise

Interventions

Breakfast DIETARY_SUPPLEMENT

All subjects received a standard 75-g OGTT to assess eligibility for the study. The 19 subjects matching the inclusion criteria completed 2 experimental trials: resting and exercise. During the resting trial, all subjects underwent an OGTT (50-g: A) and 3 meal tolerance tests \[one for each breakfast tested: B1 = milk (125ml) and cereals (30g); B2 = milk (220ml), apple (200g) and chocolate cream-filled sponge cake (30g); B3 = milk (125ml), apple (150g), bread (50g) and hazelnut chocolate cream (15g)\]. In the exercise trial, 100 minutes after the glucose/meal ingestion, participants cycled for 20 min at 40% of maximum oxygen uptake.

Breakfast with exercise; Breakfast without exercise

exercise OTHER

aerobic exercise at 40% of VO2max, for 20 minutes

Breakfast with exercise

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• age between 18 and 40 years
• normal body weight (BMI =18.5 - 24.9 according to NHLBI)
• stable diet

You may not qualify if:

• Diabetes, tipe 1 and 2 (ADA criteria)
• Glucose intolerance (ADA criteria)
• Dyslipidemia (ATP III according to NCEP)
• Metabolic syndrome

Sponsors & Collaborators

• Ospedale San Donato: lead
• University of Milan: collaborator

Related Publications (1)

• R Codella, A Caumo, S Benedini, M Adamo, A Ferrulli, C Macrì, I Terruzzi, L Luzi. Metabolic responses of a single bout of low-intensity exercise following mixed meals in healthy individuals. ADA (American Diabetes Association) 77th Scientific Session, 8-13 giugno 2017, San Diego, CA, USA. Diabetes 2017 Jun; 66 (Supplement 1).

  RESULT

MeSH Terms

Conditions

Nutrition Disorders; Motor Activity

Interventions

Breakfast; Exercise

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases; Behavior

Intervention Hierarchy (Ancestors)

Meals; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Livio Luzi, M.D.

  Gruppo San Donato

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D., Full Professor of Endocrinology

Model Details: randomized-crossover in healthy subjects

Study Record Dates

• First Submitted: August 1, 2017
• First Posted: August 7, 2017
• Study Start: July 14, 2009
• Primary Completion: May 28, 2010
• Study Completion: May 28, 2010
• Last Updated: August 7, 2017

Record last verified: 2017-08

Data Sharing

• IPD Sharing: Will not share