NCT03231865|CompletedDMC
Diagnostic of Iron Deficiency by Means of Non Invasive Measurement of Zink Protoporphyrin IX
ZnPP
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ZnPP
Sponsor study identifier
Secondary identifiers
NIH
observational
300
1 country
1
Study Start
July 27, 2017
Actual (reported)Primary Completion
February 26, 2018
Actual (reported)Study Completion
May 31, 2018
Actual (reported)ZnPP is being build in the case of a functional iron deficiency. Zinc instead of iron is implemented into protoporphyrin IX. This ZincProtoporphyrin (ZnPP) can be detected non invasively. Non invasive and invasive optical measurement of ZnPP will be compared. Additionally ZnPP measurements will be compared to other iron deficiency parameters for validation by the investigators.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 31, 2018
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 24, 2017
Actual (reported)July 27, 2017
Actual (reported)July 27, 2017
Actual (reported)February 26, 2018
Actual (reported)May 31, 2018
Actual (reported)Validation of the non-invasive ZincProtoporphyrinIX measurement
The value is compared to optical measurement of ZincProtoporphyrin in whole blood; in addition the value is compared to HPLC measurement in whole blood
Baseline
Comparison of the ZincProtoporyphyrinIX value to other iron-deficiency parameters
Baseline
Patients present themselves before an operation to the Anesthesiologist. They are screened for study eligibility.
Within 30 seconds, a measurement is performed on the lip of a patient to determine a ZincProtoporphyrin value
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients prior to a surgery, seen in the Anesthetic clinic for evaluation
University Hospital Zurich
Zurich, 8091, Switzerland
Hennig G, Homann C, Teksan I, Hasbargen U, Hasmuller S, Holdt LM, Khaled N, Sroka R, Stauch T, Stepp H, Vogeser M, Brittenham GM. Non-invasive detection of iron deficiency by fluorescence measurement of erythrocyte zinc protoporphyrin in the lip. Nat Commun. 2016 Feb 17;7:10776. doi: 10.1038/ncomms10776.
Philipp Stein, MD
Institute of Anesthesiology, University and University Hospital Zurich
300 participants (actual enrollment reported by the registry).
First Submitted
July 24, 2017
First Posted
July 27, 2017
Study Start
July 27, 2017
Actual (reported)Determination of a Dose-dependent Effect of GOS on Iron Absorption, and Addition of Vitamin C
Contact the study team to confirm eligibility.
Primary Completion
February 26, 2018
Actual (reported)Study Completion
May 31, 2018
Actual (reported)Last Updated
June 8, 2018
Record last verified: 2018-06
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Source: ClinicalTrials.gov.
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