Eealy Improvement Predicts Antidepressants Response in Adults With Major Depression Disorder
1 other identifier
observational
80
1 country
1
Brief Summary
Early improvemrnt, decreased 20% in the 17 items of Hamilton Depression Rating Scale (HAMD-17) at the second week of the treatment of major depression disorder (MDD), can arguably predict the remission at the 12th week. Our observation study including 80 MDD patients will access resting-state function MRI to finding factors which infuencing early improvemrnt, respone and remission of antidepressants.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jul 2017
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 24, 2017
CompletedStudy Start
First participant enrolled
July 25, 2017
CompletedFirst Posted
Study publicly available on registry
July 26, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 11, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
July 11, 2018
CompletedJuly 26, 2017
July 1, 2017
11 months
July 24, 2017
July 25, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Early improvement
obtain 20% decrease of HAMD-17
the second week of treatment
Secondary Outcomes (1)
Response
the 12th week of treatment
Study Arms (1)
major depressive disorder
Interventions
regular one-drups treatment of selective serotonin reuptake inhibitor(SSRIs)
Eligibility Criteria
The han nationality who living in Shanghai, Zhejiang Province and Jiangsu Province
You may qualify if:
- right-handed; HAMD-17 more than 17; diagnosed with MDD by the Structured Clinical Interview for DSM-IV
You may not qualify if:
- patients diagnosed with other condition in DSM-IV Axis I; pregnency; Thyroid disease; Heart Disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Huashan Hospitallead
Study Sites (1)
Dept. of Neurology, Huashan Hospital, Fudan University
Shanghai, Shanghai Municipality, 200040, China
Related Publications (2)
Wagner S, Engel A, Engelmann J, Herzog D, Dreimuller N, Muller MB, Tadic A, Lieb K. Early improvement as a resilience signal predicting later remission to antidepressant treatment in patients with Major Depressive Disorder: Systematic review and meta-analysis. J Psychiatr Res. 2017 Nov;94:96-106. doi: 10.1016/j.jpsychires.2017.07.003. Epub 2017 Jul 4.
PMID: 28697423BACKGROUNDSzegedi A, Jansen WT, van Willigenburg AP, van der Meulen E, Stassen HH, Thase ME. Early improvement in the first 2 weeks as a predictor of treatment outcome in patients with major depressive disorder: a meta-analysis including 6562 patients. J Clin Psychiatry. 2009 Mar;70(3):344-53. doi: 10.4088/jcp.07m03780. Epub 2009 Feb 24.
PMID: 19254516RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 3 Months
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Department of Neurology, Huashan Hospital
Study Record Dates
First Submitted
July 24, 2017
First Posted
July 26, 2017
Study Start
July 25, 2017
Primary Completion
June 11, 2018
Study Completion
July 11, 2018
Last Updated
July 26, 2017
Record last verified: 2017-07