EVALUATION OF RESPIRATORY MECHANICS AND FUNCTIONALITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

NCT03086590 | Completed

• 1 other identifier: UFPE-M1
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

To associate a lean mass, peripheral muscle strength, kinematic thoracic-abdominal, respiratory metabolic response, mobility and diaphragmatic thickness, verifying its relation with the obstruction level of COPD

Conditions

Pulmonary Disease, Chronic Obstructive

Keywords

Body composition; Ultrasound; Chronic Pulmonary Obstructive Disease; Respiratory muscles

Outcome Measures

Primary Outcomes (7)

• Fat-free mass

  Mass of the human body disregarding fat.

  Baseline

• Quadriceps Force

  Quadriceps muscle strength measured during maximum voluntary contraction.

  Baseline

• Handgrip strength

  Maximum voluntary manual holding force.

  Baseline

• Total chest wall volume

  Total volume resulting from the sum of the volume of the pulmonary compartment of the costal, abdominal gradient of the costal and abdominal beds.

  Baseline

• Oxygen uptake

  Consumption of oxygen during an effort.

  Baseline

• Diaphragm mobility

  It is the diaphragmatic movement from the end of the expiration until the end of the inspiration, being able to be realized in tidal volume or starting from the total pulmonary capacity.

  Baseline

• Diaphragm thickness

  Defined as a corpulence of the diaphragm muscle

  Baseline

Study Arms (4)

Group 1

COPD mild. The individuals allocated to this group have FEV1 ≥ 80% predicted.

Group 2

COPD Moderate. The individuals allocated to this group have 50% ≤ FEV1 \< 80% predicted.

Group 3

COPD Severe. The individuals allocated to this group have 30% ≤ FEV1 \< 50% predicted.

Group 4

COPD Very severe. The individuals allocated to this group have FEV1 \< 30% predicted.

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with Chronic Obstructive Pulmonary Disease, selected at the Hospital das Clínicas of the Federal University of Pernambuco, Hospital Otávio de Freitas and Pharmacy of the State of Pernambuco.

You may qualify if:

• Young adults, adults and elderly subjects

You may not qualify if:

• Others respiratory diseases;
• Heart diseases;
• Those who are in some previous training program or rehabilitation;

Sponsors & Collaborators

• Universidade Federal de Pernambuco: lead

Study Sites (1)

Universidade Federal de Pernambuco

Recife, Pernambuco, 50670-901, Brazil

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 9, 2017
• First Posted: March 22, 2017
• Study Start: November 1, 2016
• Primary Completion: February 1, 2018
• Study Completion: March 1, 2018
• Last Updated: November 7, 2018

Record last verified: 2018-11

Locations

BR (1)