Boston Birth Cohort Study
Early Life Origins of Pediatric and Adult Diseases: Boston Birth Cohort Study
1 other identifier
observational
24,000
1 country
1
Brief Summary
Early life exposures may lead to adverse effects on health in later life. The Boston birth Cohort study is designed to study a broad array of early life factors and their effects on maternal and child health outcomes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 1998
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 1998
CompletedFirst Submitted
Initial submission to the registry
July 20, 2017
CompletedFirst Posted
Study publicly available on registry
July 25, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2028
September 17, 2025
September 1, 2025
30.2 years
July 20, 2017
September 11, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (5)
Pregnancy complications
Multiple pregnancy complications are examined including gestational diabetes, hypertensive disorders of pregnancy.
At birth
Birth outcomes - preterm birth
Birth outcomes are examined - preterm birth.
At birth
Birth outcomes - birthweight
Birth outcomes are examined - birthweight.
At birth
Child health outcomes
Multiple child health outcomes are examined including food allergy, asthma, child's overweight or obesity, blood pressure, and child neuro-developmental outcomes.
From birth to 21 years
Maternal health outcomes
Multiple maternal health outcomes are measured including blood pressure, weight, height, physician diagnosis.
After delivery to 21 years
Eligibility Criteria
US, predominantly urban, BIPOC (Black, Indigenous, and people of color).
You may qualify if:
- Mothers who deliver singleton live births at Boston Medical Center are eligible for the study.
You may not qualify if:
- pregnancies that are a result of in vitro fertilization or that involve multiple gestations, fetal chromosomal abnormalities or major birth defects.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Boston Medical Center
Boston, Massachusetts, 02118, United States
Related Publications (8)
Yaskolka Meir A, Wang G, Hong X, Hu FB, Wang X, Liang L. Newborn DNA methylation age differentiates long-term weight trajectories: the Boston Birth Cohort. BMC Med. 2024 Sep 11;22(1):373. doi: 10.1186/s12916-024-03568-9.
PMID: 39256781DERIVEDCameron K, Borahay M, Hong X, Baker V, Vaught A, Wang X. Uterine fibroids and risk of hypertensive disorders of pregnancy - results from a racially diverse high-risk cohort. medRxiv [Preprint]. 2024 Mar 7:2024.03.05.24303830. doi: 10.1101/2024.03.05.24303830.
PMID: 38496516DERIVEDHong X, Rosenberg AZ, Heymann J, Yoshida T, Waikar SS, Ilori TO, Wang G, Rebuck H, Pearson C, Wang MC, Winkler CA, Kopp JB, Wang X. Joint Associations of Pregnancy Complications and Postpartum Maternal Renal Biomarkers With Severe Cardiovascular Morbidities: A US Racially and Ethnically Diverse Prospective Birth Cohort Study. J Am Heart Assoc. 2023 Nov 21;12(22):e029311. doi: 10.1161/JAHA.122.029311. Epub 2023 Nov 10.
PMID: 37947096DERIVEDMcArthur KL, Zhang M, Hong X, Wang G, Buckley JP, Wang X, Mueller NT. Trimethylamine N-Oxide and Its Precursors Are Associated with Gestational Diabetes Mellitus and Pre-Eclampsia in the Boston Birth Cohort. Curr Dev Nutr. 2022 Jun 21;6(7):nzac108. doi: 10.1093/cdn/nzac108. eCollection 2022 Jul.
PMID: 35949367DERIVEDHuang W, Igusa T, Wang G, Buckley JP, Hong X, Bind E, Steffens A, Mukherjee J, Haltmeier D, Ji Y, Xu R, Hou W, Tina Fan Z, Wang X. In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals. Int J Obes (Lond). 2022 Aug;46(8):1435-1445. doi: 10.1038/s41366-022-01127-x. Epub 2022 May 19.
PMID: 35589962DERIVEDLee ASE, Ji Y, Raghavan R, Wang G, Hong X, Pearson C, Mirolli G, Bind E, Steffens A, Mukherjee J, Haltmeier D, Fan ZT, Wang X. Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study. Autism Res. 2021 Dec;14(12):2533-2543. doi: 10.1002/aur.2617. Epub 2021 Sep 24.
PMID: 34558795DERIVEDOlapeju B, Hong X, Wang G, Summers A, Burd I, Cheng TL, Wang X. Birth outcomes across the spectrum of maternal age: dissecting aging effect versus confounding by social and medical determinants. BMC Pregnancy Childbirth. 2021 Sep 1;21(1):594. doi: 10.1186/s12884-021-04077-w.
PMID: 34470614DERIVEDOlapeju B, Ahmed S, Hong X, Wang G, Summers A, Cheng TL, Burd I, Wang X. Maternal Hypertensive Disorders in Pregnancy and Postpartum Plasma B Vitamin and Homocysteine Profiles in a High-Risk Multiethnic U.S., Population. J Womens Health (Larchmt). 2020 Dec;29(12):1520-1529. doi: 10.1089/jwh.2020.8420. Epub 2020 Nov 16.
PMID: 33252313DERIVED
Biospecimen
Plasma, red blood cell, placenta, urine, DNA, RNA, Swab, Stool
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Xiaobin Wang, MD, ScD
Johns Hopkins Bloomberg School of Public Health
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 21 Years
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 20, 2017
First Posted
July 25, 2017
Study Start
October 1, 1998
Primary Completion (Estimated)
December 1, 2028
Study Completion (Estimated)
December 1, 2028
Last Updated
September 17, 2025
Record last verified: 2025-09
Data Sharing
- IPD Sharing
- Will not share