NCT03228446

Brief Summary

The investigators are interested in how attentional filter training/ distractor inhibition training could influence cognitive functions like working memory, executive control, problem solving, decision making and attentional control.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Sep 2012

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 26, 2012

Completed
4.8 years until next milestone

First Submitted

Initial submission to the registry

July 12, 2017

Completed
13 days until next milestone

First Posted

Study publicly available on registry

July 25, 2017

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2018

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2019

Completed
Last Updated

February 15, 2019

Status Verified

February 1, 2019

Enrollment Period

6.2 years

First QC Date

July 12, 2017

Last Update Submit

February 12, 2019

Conditions

Cognitive DeclineHealthyAge-related Cognitive Decline

Keywords

training interventionfilter trainingdistractor inhibition

Outcome Measures

Primary Outcomes (1)

  • Improvements in test performance

    Working memory and filtering performance (in %), effects of distractor interference and reaction times for trials with and without distractors with 4, 5 \& 6 targets

    45min pre / post

Secondary Outcomes (14)

  • Rey Complex Figure Test

    30min pre / post

  • Memory from TAP (Test battery of Attentional Performance)

    45min pre / post

  • Attention from TAP (Test battery of Attentional Performance)

    45min pre / post

  • Performance in repeating numbers

    10min pre / post

  • Subtest from CANTAB (Cambridge Neuropsychological Test Automated Battery)

    10min pre / post

  • +9 more secondary outcomes

Study Arms (2)

Young subjects

EXPERIMENTAL

Working memory training \& attentional filter training for participants (18-30 years)

Behavioral: filter trainingBehavioral: memory training

Old subjects

EXPERIMENTAL

Working memory training, attentional filter training and no training (control) for participants (60-80 years)

Behavioral: filter trainingBehavioral: memory trainingOther: no training (control)

Interventions

filter trainingBEHAVIORAL

one-week filter training on the computer: computerized visual change detection experiment (selective attention )

Old subjectsYoung subjects
memory trainingBEHAVIORAL

one-week storage training on the computer: computerized visual change detection experiment (memory storage)

Old subjectsYoung subjects
no training (control)OTHER

no training applied

Old subjects

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • right-hander
  • aged between 18-30 or 60-80years

You may not qualify if:

  • severe visual impairments (e.g. dyschromatopsia, very low vision)
  • diseases or medication that might impair test performance
  • Montreal Cognitive Assessment Score (MoCA) \< 26 points

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

DZNE

Magdeburg, Saxony-Anhalt, 39120, Germany

Location

Related Publications (2)

  • Schmicker M, Schwefel M, Vellage AK, Muller NG. Training of Attentional Filtering, but Not of Memory Storage, Enhances Working Memory Efficiency by Strengthening the Neuronal Gatekeeper Network. J Cogn Neurosci. 2016 Apr;28(4):636-42. doi: 10.1162/jocn_a_00922. Epub 2016 Jan 14.

    PMID: 26765946RESULT

  • Schmicker M, Muller P, Schwefel M, Muller NG. Attentional Filter Training but Not Memory Training Improves Decision-Making. Front Hum Neurosci. 2017 Mar 23;11:138. doi: 10.3389/fnhum.2017.00138. eCollection 2017.

    PMID: 28386225RESULT

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Cognition DisordersNeurocognitive DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Neurological RehabilitationRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsHealth ServicesHealth Care Facilities Workforce and Services

Study Officials

  • Notger Müller, Prof. Dr.

    German Center for Neurodegenerative Diseases (DZNE)

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Prof. Dr. med. (Head of Neuroprotection Lab at the DZNE)

Study Record Dates

First Submitted

July 12, 2017

First Posted

July 25, 2017

Study Start

September 26, 2012

Primary Completion

December 1, 2018

Study Completion

January 1, 2019

Last Updated

February 15, 2019

Record last verified: 2019-02

Data Sharing

IPD Sharing
Will not share

Locations

DE(1)