NCT03227952

Brief Summary

The purpose of this study is to investigate the effectiveness of low-intensity and prolonged vibrotactile sensory stimulation on symptom relieve in fibromyalgia patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
77

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2017

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 18, 2017

Completed
6 days until next milestone

First Posted

Study publicly available on registry

July 24, 2017

Completed
1 month until next milestone

Study Start

First participant enrolled

September 4, 2017

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 31, 2018

Completed
Last Updated

October 17, 2018

Status Verified

October 1, 2018

Enrollment Period

9 months

First QC Date

July 18, 2017

Last Update Submit

October 16, 2018

Conditions

Outcome Measures

Primary Outcomes (1)

  • 101-point verbal rating scale (VRS)

    Change on fibromyalgia key symptoms rated using 101-point verbal rating scale (combining pain, fatigue and subjective cognitive problems).

    3 weeks

Secondary Outcomes (1)

  • Associated symptom improvement

    3 weeks

Study Arms (2)

Active treatment

ACTIVE COMPARATOR

Vibrotactile sensory stimulation

Device: Vibrotactile stimulation

Sham

SHAM COMPARATOR

Identical device. No vibration

Device: Vibrotactile stimulation

Interventions

Vibrotactile sensory stimulation will consist on whole-body stimulation with mechanical stimuli of pallesthetic type at high rate (20-90 Hz), low intensity and long daily duration (3h).

Active treatmentSham

Eligibility Criteria

Age18 Years - 65 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • A diagnosis of fibromyalgia according to the American College of Rheumatology (ACR) (Arthritis Rheum, 1990;33:160-172)
  • Diagnoses established by an expert on fibromyalgia.
  • Stable treatment of chronic use.
  • Subject demonstrates an understanding of the study and a willingness to participate as evidenced by voluntary written informed consent.

You may not qualify if:

  • Generalized inflammatory articular or rheumatic disease.
  • Heavily exercise for 12 hours prior to fMRI assessment
  • Severe, non-stable medical, endocrinological or neurological disorder.
  • Psychotic disorder or drug abuse.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hospital del Mar

Barcelona, 08003, Spain

Location

Related Publications (1)

  • Pujol J, Ramos-Lopez D, Blanco-Hinojo L, Pujol G, Ortiz H, Martinez-Vilavella G, Blanch J, Monfort J, Deus J. Testing the effects of gentle vibrotactile stimulation on symptom relief in fibromyalgia. Arthritis Res Ther. 2019 Jun 14;21(1):148. doi: 10.1186/s13075-019-1932-9.

MeSH Terms

Conditions

Fibromyalgia

Condition Hierarchy (Ancestors)

Muscular DiseasesMusculoskeletal DiseasesRheumatic DiseasesNeuromuscular DiseasesNervous System Diseases

Study Officials

  • Jesus Pujol, MD

    Hospital del Mar

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Masking Details
a sham device identical to the active device
Purpose
TREATMENT
Intervention Model
CROSSOVER
Model Details: Parallel Assignment
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

July 18, 2017

First Posted

July 24, 2017

Study Start

September 4, 2017

Primary Completion

May 31, 2018

Study Completion

May 31, 2018

Last Updated

October 17, 2018

Record last verified: 2018-10

Data Sharing

IPD Sharing
Will not share

Locations