IMPROVENT
Sponsor study identifier
observational
8,692
1 country
1
Study Start
March 2016
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 1, 2022
Actual (reported)Study Completion
December 1, 2022
Actual (reported)This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a proven standardized lung protective ventilation protocol in the new electronic medical record system iCentra across all Intermountain Healthcare hospitals. Approximately 14,000 records will be accessed for this study from a database of mechanically ventilated patients established for quality improvement purposes. The investigators hypothesize that implementation of a standardized computerized lung protective ventilation protocol across all Intermountain Healthcare hospitals will be feasible, will decrease initial tidal volumes to the target 6 ml/kg PBW, and will improve outcomes. The objectives of this study are to:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 1, 2022
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2016
Date type not reportedThis date has not been verified as actual or estimated.
July 14, 2017
Actual (reported)July 21, 2017
Actual (reported)December 1, 2022
Actual (reported)December 1, 2022
Actual (reported)Ventilator free days to day 28
28 days
30 day mortality
30 days
90 day mortality
90 days
Hospital discharge disposition
30 days
Patient Selection Those to be enrolled must have respiratory failure requiring intubation and initiation of mechanical ventilation. Patients will be divided into two different groups: those patients who are managed with the computerized lung protective ventilation protocol as ordered by the attending physician and those patients managed with physician specified mechanical ventilation settings.
Colin Grissom
Murray, Utah, 84121, United States
Grissom CK, Lanspa MJ, Groat D, Jacobs JR, Carpenter L, Kuttler KG, Leither L, Peltan ID, Brown SM, Srivastava R. Implementation of Lung-Protective Ventilation in Patients With Acute Respiratory Failure. Crit Care Med. 2023 Jun 1;51(6):797-807. doi: 10.1097/CCM.0000000000005840. Epub 2023 Mar 29.
Colin Grissom, MD
Intermountain Health Care, Inc.
8,692 participants (actual enrollment reported by the registry).
First Submitted
July 14, 2017
First Posted
July 21, 2017
Study Start
March 2016
Date type not reportedThis date has not been verified as actual or estimated.
Hospital mortality
1 week
Time to first ICU activity
24 hours
Contact the study team to confirm eligibility.
Primary Completion
December 1, 2022
Actual (reported)Study Completion
December 1, 2022
Actual (reported)Last Updated
March 12, 2024
Record last verified: 2024-03
Individual data will not be shared.
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Source: ClinicalTrials.gov.
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