How do Super Lean Subjects Keep Resistant to Body Weight Gain?

NCT03221322 | Unknown

• 1 other identifier: 0060
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is the 5th leading cause of global death, and is major risk factors for many chronic diseases, such as type 2 diabetes, cardiovascular diseases, hypertension and cancer. Obesity is caused by an imbalance between energy intake and energy expenditure, and it is widely agreed to be a consequence of a gene by environment interaction. Although on average obesity rates are increasing, the shape of the distribution of adiposity is changing: it is becoming more right skewed. This is because there is a population of very lean subjects that has remained almost unchanged by the epidemic. The investigators have called these very lean individuals that are resistant to the epidemic and sustain a BMI \< 18.5 kg/m2 'super lean' subjects. We have very little understanding of the lifestyles of these individuals and how they are able to maintain their super lean phenotype, and whether the basis of their leanness is primarily genetics.

Conditions

Thinness; Health Behavior; Genetics

Outcome Measures

Primary Outcomes (2)

• Anthropometric measurements of participants in both control and superlean groups

  Height, waist and hip circumferences (cm) and body composition will be measured on arrival.

  Through study completion, an average of 2 years

• Demographic characteristics of all participants in both control and superlean groups

  Life style questionnaire filled out on arrival.

  Through study completion, an average of 2 years

Study Arms (2)

Control

20 kg/m2 ≤ BMI ≤ 25 kg/m2, healthy, with no eating disorder, 150 subjects, 20 - 40 years old

Behavioral: Superlean

Superlean

15 kg/m2 ≤ BMI ≤ 18 kg/m2, healthy, with no eating disorder, 150 subjects, 25 - 35 years old in particular

Behavioral: Superlean

Interventions

Superlean BEHAVIORAL

Behavioural data will be collected on all subjects in either control group or superlean group. Blood or saliva samples will be collected for DNA extraction and genotyping.

Control; Superlean

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Participants are healthy, with no eating disorder, 25 - 35 years old in particular.

You may qualify if:

• control: BMI 20-25 kg/m2, healthy, age 20-40 years old superlean: BMI 15-18 kg/m2, healthy, with no eating disorders and diabetes, age 20-40 years old

You may not qualify if:

• Pregnant women and women in lactation Subjects are suffering from eating disorders or diabetes.

Sponsors & Collaborators

• Chinese Academy of Medical Sciences: lead

Study Sites (1)

Institute of Genetics and Developmental Biology

Beijing, 100101, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

9 ml of blood samples will be collected for the biological measurements and DNA extraction for genotyping.

MeSH Terms

Conditions

Thinness; Health Behavior

Condition Hierarchy (Ancestors)

Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• John Speakman, PhD

  Institute of Genetics and Developmental Biology

  PRINCIPAL INVESTIGATOR

Central Study Contacts

John Speakman, PhD

CONTACT

+86-10-64807042; j.speakman@abdn.ac.uk

Sumei Hu, PhD

CONTACT

18500818466; smhu@genetics.ac.cn

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 27, 2017
• First Posted: July 18, 2017
• Study Start: April 6, 2017
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: July 21, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)