Effects of Microbouts of Activity on Metabolic Health

NCT02998892 | Completed

• 1 other identifier: 16-1769
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Population studies suggest that time spent in sedentary behaviors is associated with all-cause mortality including obesity, diabetes, and cardiovascular diseases, independent of time spent in exercise. Frequent interruptions to sedentary time are however beneficially associated with metabolic health outcomes, even in individuals who exercise regularly. The goal is to use integrative approach to understand the biological mechanisms that underlie these associations in a longitudinal intervention study in overweight sedentary adults. The investigators believe that the proposed study will provide an initial evidence base for the health benefits of breaking up prolonged sitting with short bursts of activity. This innovative strategy may be more effective at combating the adverse effects of sedentary behaviors than more traditional approaches.

Conditions

Health Behavior

Keywords

Sedentary Behavior

Outcome Measures

Primary Outcomes (3)

• Changes in sedentary time as measured by ActiPAL

  Over each 2 week period, participants will be instructed to wear an ActiPAL (PALTechnologies: Glasgow, Scotland) activity monitor on their right leg. Participants will be instructed to wear the monitors at all times except when sleeping or participating in water-based activities. The time-stamped "event" data file from the activPAL software will be used to determine time spent sitting/lying, standing and stepping per day.

  weeks 1-2 and weeks 5-6

• Changes in insulin sensitivity

  Insulin sensitivity will be determined via an insulin modified frequently sampled intra-venous glucose tolerance test (IVGTT). After baseline samples, intravenous glucose (0.3 g/kg) will be infused over 1 minute, followed by insulin at 0.03 U/kg, 20 minutes after glucose administration. Blood samples will be frequently sampled over 5 hours, and insulin sensitivity will be calculated using the Bergman minimal model.

  Week 2 and week 8

• Postprandial glycemia

  Incremental area under the curve of plasma glucose concentration measured in fasting and every hour for 14 hours.

  Week 2 and week 8

Secondary Outcomes (12)

• Changes in total energy expenditure (TEE)

  week 1-2 and week 5-6

• Changes in Moderate-to-vigorous physical activity as measured by ActiGraph

  weeks 1-6

• 24hr substrate oxidation and energy expenditure

  Week 2 and week 8

• Changes in Dietary Carbohydrate Oxidation

  week 2 and week 8

• Changes in Dietary Fat Oxidation

  week 2 and week 8

Other Outcomes (1)

• Self-perceived appetite and hunger

  Week 2 and week 8

Study Arms (2)

Traditional Exercise Training

ACTIVE COMPARATOR

Participants will be asked to perform moderate-intensity exercise (brisk walking) for 45 minutes for 5 days/week for 6 weeks. This intervention corresponds to the current recommendations.

Behavioral: Traditional Exercise Training

Daily Microbursts of Activity

EXPERIMENTAL

Participants will be asked to break up their sedentary activities of daily living for 5-minutes every hour for 9 hours, 5 days/week, by brisk walking for 6 weeks.

Behavioral: Daily Microbursts of Activity

Interventions

Traditional Exercise Training BEHAVIORAL

Participants will be asked to perform moderate-intensity exercise (brisk walking) for 45 minutes for 5 days/week for 6 weeks. This intervention corresponds to the current recommendations.

Traditional Exercise Training

Daily Microbursts of Activity BEHAVIORAL

Participants will be asked to break up their sedentary activities of daily living for 5-minutes every hour for 9 hours, 5 days/week, by brisk walking for 6 weeks.

Daily Microbursts of Activity

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Overweight but weight stable (+/- 3kg over previous 6 months) sedentary male and female adults (n=30) will be recruited.
• Ages between 18-45 years old
• BMI of 25-35 kg/m2
• Sedentary ( self report \< 150min/wk of moderate-to-vigorous activity or less than 6,500 steps per day as measured for 5 days in free-living conditions with a pedometer).
• The use of birth pill control will be accepted

You may not qualify if:

• Any history of renal (present or past kidney failure, kidney transplant, dialysis or kidney cysts),
• Uncontrolled hypertension
• Cardiovascular (present or past atherosclerosis, heart attack, ischemic stroke, heart failure)
• Hepatic diseases (past or present hepatitis B or C, fibrosis, cirrhosis, NAFLD/NASH)
• Type 1 or 2 diabetes
• Cancer
• Smoking
• Consumption of drugs (marijuana included)
• Consumption of alcohol (\>40g/d)
• HIV positivity
• Psychiatric disorders
• Any medications known to interfere with lipid or energy metabolism
• Known physical activity contraindications
• Major illness/physical problems (acute or chronic) that may limit their ability to perform the walking activities

Sponsors & Collaborators

• University of Colorado, Denver: lead
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): collaborator

Study Sites (1)

University of Colorado Hospital

Aurora, Colorado, 80045, United States

Location

MeSH Terms

Conditions

Health Behavior; Sedentary Behavior

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Audrey Bergouignan, PhD

  University of Colorado, Denver

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 2, 2016
• First Posted: December 21, 2016
• Study Start: May 9, 2017
• Primary Completion: October 8, 2021
• Study Completion: October 8, 2021
• Last Updated: November 18, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)