University Hospital Advanced Age Pregnant Cohort
UNIHOPE
1 other identifier
observational
22,000
1 country
9
Brief Summary
The University Hospital Advanced Age Pregnant (UNIHOPE) Cohort is the major part of the National Key Research and Development Program on Reproductive Health \& Major Birth Defects Control and Prevention Project, which is funded by the Ministry of Science and Technology of China. The Project is led by Prof. Zhao Yangyu, from the Department of Gynecology \& Obstetrics, Peking University Third Hospital, and the UNIHOPE cohort is led by Prof. Jian-meng Liu, the Co-PI of the Project.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2017
Typical duration for all trials
9 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 28, 2017
CompletedFirst Submitted
Initial submission to the registry
July 12, 2017
CompletedFirst Posted
Study publicly available on registry
July 18, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2020
CompletedJuly 18, 2017
July 1, 2017
3.8 years
July 12, 2017
July 13, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Incidence of major gestational complications and adverse pregnancy outcomes in pregnant women with the advanced age, for a singleton or twin and higher order multiple gestation
Gestational diabetes mellitus, hypertensive disease of pregnancy, uterine scar pregnancy, placenta previa, preterm delivery, postpartum hemorrhage, low birth weight, spontaneous abortion, stillbirth, perinatal death
At enrollment, 24-28 weeks, 32-34 weeks of gestation, delivery, and 42 days postpartum
Secondary Outcomes (5)
Maternal death
At 24-28 weeks, 32-34 weeks of gestation, delivery, and 42 days postpartum
The rate of cesarean delivery
At delivery
Gestational duration
At enrollment, delivery
Birth weight
At delivery
Birth length
At delivery
Eligibility Criteria
The UNIHOPE Cohort is a prospective cohort study that will enroll \~22000 pregnant women aged 35 years and over from 9 large obstetrical center of University-Affiliated Hospitals. These hospitals locate at 7 supercities (Beijing, Shanghai, Guangdong, Shenyang, Wuhan, Chongqing and Chengdu) of China. Pregnant women who are planning to recieve prenatal healthcare and delivery in those hospitals are potential candidates for the study.
You may qualify if:
- Female aged ≥ 35 years
- Less than 14 gestational weeks
- Planning to receive prenatal healthcare and delivery service at the study hospital
You may not qualify if:
- Inability to provide informed consent
- Women with mental disorders
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Peking Universitylead
- Peking University Third Hospitalcollaborator
- Peking University First Hospitalcollaborator
- Obstetrics & Gynecology Hospital of Fudan Universitycollaborator
- Shengjing Hospitalcollaborator
- The Third Affiliated Hospital of Guangzhou Medical Universitycollaborator
- West China Second University Hospitalcollaborator
- First Affiliated Hospital of Chongqing Medical Universitycollaborator
- Beijing Obstetrics and Gynecology Hospitalcollaborator
- Tongji Hospitalcollaborator
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciencescollaborator
Study Sites (9)
Peking University First Hospital
Beijing, 100034, China
Beijing Obstetrics and Gynecology Hospital, Capital Medical University
Beijing, 100069, China
Peking University Third Hospital
Beijing, 100191, China
West China Second University Hospital
Chengdu, 610000, China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, 400010, China
The Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, 510000, China
Obstetrics and Gynecology Hospital of Fudan University
Shanghai, 200000, China
Shengjing Hospital of China Medical University
Shenyang, 110000, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, 430000, China
Related Publications (11)
Laopaiboon M, Lumbiganon P, Intarut N, Mori R, Ganchimeg T, Vogel JP, Souza JP, Gulmezoglu AM; WHO Multicountry Survey on Maternal Newborn Health Research Network. Advanced maternal age and pregnancy outcomes: a multicountry assessment. BJOG. 2014 Mar;121(Suppl 1):49-56. doi: 10.1111/1471-0528.12659.
PMID: 24641535BACKGROUNDNgowa JD, Ngassam AN, Dohbit JS, Nzedjom C, Kasia JM. Pregnancy outcome at advanced maternal age in a group of African women in two teaching Hospitals in Yaounde, Cameroon. Pan Afr Med J. 2013 Apr 7;14:134. doi: 10.11604/pamj.2013.14.134.2315. Print 2013.
PMID: 23734279BACKGROUNDCarolan M. Maternal age >/=45 years and maternal and perinatal outcomes: a review of the evidence. Midwifery. 2013 May;29(5):479-89. doi: 10.1016/j.midw.2012.04.001. Epub 2012 Nov 16.
PMID: 23159159BACKGROUNDKhalil A, Syngelaki A, Maiz N, Zinevich Y, Nicolaides KH. Maternal age and adverse pregnancy outcome: a cohort study. Ultrasound Obstet Gynecol. 2013 Dec;42(6):634-43. doi: 10.1002/uog.12494.
PMID: 23630102BACKGROUNDLisonkova S, Potts J, Muraca GM, Razaz N, Sabr Y, Chan WS, Kramer MS. Maternal age and severe maternal morbidity: A population-based retrospective cohort study. PLoS Med. 2017 May 30;14(5):e1002307. doi: 10.1371/journal.pmed.1002307. eCollection 2017 May.
PMID: 28558024BACKGROUNDCleary-Goldman J, Malone FD, Vidaver J, Ball RH, Nyberg DA, Comstock CH, Saade GR, Eddleman KA, Klugman S, Dugoff L, Timor-Tritsch IE, Craigo SD, Carr SR, Wolfe HM, Bianchi DW, D'Alton M; FASTER Consortium. Impact of maternal age on obstetric outcome. Obstet Gynecol. 2005 May;105(5 Pt 1):983-90. doi: 10.1097/01.AOG.0000158118.75532.51.
PMID: 15863534BACKGROUNDLisonkova S, Janssen PA, Sheps SB, Lee SK, Dahlgren L. The effect of maternal age on adverse birth outcomes: does parity matter? J Obstet Gynaecol Can. 2010 Jun;32(6):541-548. doi: 10.1016/S1701-2163(16)34522-4.
PMID: 20569534BACKGROUNDNiessen K, Werner-Bierwisch T, Metzing S, Sayn-Wittgenstein FZ. [Motherhood at the Age of 35 and Over: The Risk of Advanced Maternal Age as Perceived by Women - a Literature Study]. Z Geburtshilfe Neonatol. 2017 Jun;221(3):111-121. doi: 10.1055/s-0043-104864. Epub 2017 Jun 30. German.
PMID: 28666302BACKGROUNDTaghizadeh Z, Cheraghi MA, Kazemnejad A, Pooralajal J, Aghababaei S. Difference in Perception of Pregnancy Risk in Two Maternal Age Groups. J Clin Diagn Res. 2017 May;11(5):QC09-QC12. doi: 10.7860/JCDR/2017/23661.9915. Epub 2017 May 1.
PMID: 28658853BACKGROUNDJolly M, Sebire N, Harris J, Robinson S, Regan L. The risks associated with pregnancy in women aged 35 years or older. Hum Reprod. 2000 Nov;15(11):2433-7. doi: 10.1093/humrep/15.11.2433.
PMID: 11056148BACKGROUNDYin S, Zhou Y, Zhao C, Yang J, Yuan P, Zhao Y, Qi H, Wei Y. Association of Paternal Age Alone and Combined with Maternal Age with Perinatal Outcomes: A Prospective Multicenter Cohort Study in China. J Epidemiol Glob Health. 2024 Mar;14(1):120-130. doi: 10.1007/s44197-023-00175-4. Epub 2024 Jan 8.
PMID: 38190051DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Yangyu Zhao, PhD
Peking University Third Hospital
- PRINCIPAL INVESTIGATOR
Jian-meng Liu, PhD
Peking University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof.
Study Record Dates
First Submitted
July 12, 2017
First Posted
July 18, 2017
Study Start
March 28, 2017
Primary Completion
December 31, 2020
Study Completion
December 31, 2020
Last Updated
July 18, 2017
Record last verified: 2017-07