Birth Cohort Study of China Medical University
1 other identifier
observational
1,000
1 country
1
Brief Summary
The CMUBCS is a birth cohort study located in Shenyang, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental factors, family and lifestyle, clinical experimental outcomes and imaging results of pregnant women and children from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the children and their parents.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2018
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 21, 2018
CompletedStudy Start
First participant enrolled
June 15, 2018
CompletedFirst Posted
Study publicly available on registry
June 19, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2037
ExpectedDecember 12, 2019
December 1, 2019
2 years
May 21, 2018
December 9, 2019
Conditions
Outcome Measures
Primary Outcomes (5)
Change of biometric parameter in centimeter of fetuses at the thirteenth week of gestational age
Including head circumference, abdominal circumference, biparietal diameter, femur length of singleton and twin pregnancy
At every week from the thirteenth week of gestational age to delivery of babies
Weight in kilogram of neonate
Including singleton and twin pregnancy measured by nurses
At birth of neonate
Gene expression of husbands of pregnancy women
DNA methylation, histone acetylation etc. assessed by analyses of blood
At 13 weeks of gestational age
Change of gene expression of pregnancy women
DNA methylation, histone acetylation etc. assessed by analyses of blood
At 13, 26 and 34 weeks of gestational age
Result of Non-invasive Prenatal Testing
including singleton and twin pregnancy
From 12 to 22 weeks of gestational age
Secondary Outcomes (4)
Change of intestinal flora during early childhood
Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years
Height in centimeter changes during childhood
Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years
Weight in kilogram changes during childhood
Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years
Change of gene expression during childhood
Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years
Eligibility Criteria
Pregnant women in Shenyang, China and their husband and children
You may qualify if:
- Pregnant women, \<13 gestational weeks
- Permanent residents or families intended to remain in Shenyang and surrounding areas
- Pregnant women who are planned to be examined and delivered in Shengjing Hospital.
You may not qualify if:
- Pregnant women who refuse to take part in the study
- Pregnant women have diseases that might affect the results of researches, including neuropsychiatric disorders.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Shengjing Hospital
Shenyang, Liaoning, 110004, China
Related Publications (1)
Zhang L, Du Y, Zhou J, Liu C, Li J, Qiao C. Timing of diagnostic workups in Chinese population with recurrent pregnancy loss: a cross-sectional study. BMC Pregnancy Childbirth. 2025 Mar 29;25(1):373. doi: 10.1186/s12884-025-07330-8.
PMID: 40158174DERIVED
Biospecimen
During pregnancy: maternal blood, urine and stool ; fetal blood and oral mucosal cell At delivery: cord, cord blood and placenta During Infancy：dry blood spot During childhood: blood, buccal swab and stool
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Caixia Liu
Shengjing Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director of the second obstetrical department
Study Record Dates
First Submitted
May 21, 2018
First Posted
June 19, 2018
Study Start
June 15, 2018
Primary Completion
June 1, 2020
Study Completion (Estimated)
June 1, 2037
Last Updated
December 12, 2019
Record last verified: 2019-12
Data Sharing
- IPD Sharing
- Will not share