Red Meat, Increased Iron Load and CVD Risk

NCT03218020 | Completed

• 1 other identifier: DKFZ Study_ID 905
• Study Type: observational
• Target: 25,540
• Locations: 1 country
• Sites: 1

Brief Summary

Increased iron load could be a risk factor for cardiovascular diseases (CVD). Red meat consumption affects iron status and has also been shown to be related to increased CVD risk. The investigators hypothesized that risk associations between red meat intake and cardiovascular disease risk can to some degree be explained by higher iron load among individuals with higher meat intake. Thus, the investigators evaluate associations between red meat consumption, iron status, and CVD risk in a large-scale population based study, the European Prospective Investigation into Cancer and Nutrition (EPIC) - Heidelberg.

Conditions

Myocardial Infarction; Stroke; Cardiovascular Mortality

Outcome Measures

Primary Outcomes (3)

• Myocardial infraction

  Incident cases of primary myocardial infarction according to clinical records

  1994 - 2009

• Stroke

  Incident cases of primary stroke according to clinical records

  1994 - 2009

• Cardiovascular death

  Incident cases of cardiovascular death according to death certificates

  1994 - 2009

Study Arms (2)

Random Subcohort

Random subcohort (\~10 % of the initial cohort, study has a case-cohort design; details on the case-cohort design have been described by Kulathinal et al., Epidemiol Perspect Innov, 2007: www.ncbi.nlm.nih.gov/pmc/articles/PMC2216006/).

Other: No intervention assigned, this is an observational study.

Incident CVD Cases

Validated incident cases of myocardial infarction, stroke and CVD death that occured until Dec-31-2009 (details on the case-cohort design have been described by Kulathinal et al., Epidemiol Perspect Innov, 2007: www.ncbi.nlm.nih.gov/pmc/articles/PMC2216006/).

Other: No intervention assigned, this is an observational study.

Interventions

No intervention assigned, this is an observational study. OTHER

No intervention assigned, this is an observational study.

Incident CVD Cases; Random Subcohort

Eligibility Criteria

• Age: 35 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

EPIC-Heidelberg was launched as part of EPIC-Europe between 1994 and 1998, when 13 611 female and 11 929 male participants aged 35 to 65 years were recruited from the local general population.

You may qualify if:

• General population, age 35-65 years

You may not qualify if:

• Prevalent myocardial infraction or stroke

Sponsors & Collaborators

• German Cancer Research Center: lead

Study Sites (1)

German Cancer Research Center

Heidelberg, 69120, Germany

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum samples from baseline examinations stored in the biobank of the study.

MeSH Terms

Conditions

Myocardial Infarction; Stroke

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Rudolf Kaaks, Prof.

  German Cancer Research Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 13, 2017
• First Posted: July 14, 2017
• Study Start: September 1, 1994
• Primary Completion: December 31, 2009
• Study Completion: December 31, 2009
• Last Updated: July 18, 2017

Record last verified: 2017-07

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)