Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage

NCT03214705 | Completed

• 1 other identifier: CTP predicts DCI
• Study Type: observational
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

Prospective evaluation of patients with subarachnoid hemorrhage (SAH) will be done by computed tomography angiography (CTA) and perfusion imaging (CTP) for any correlation between degree of vasospasm and perfusion deficit as well as evaluating the ability of CTP to predict delayed cerebral ischemia.

Conditions

Subarachnoid Hemorrhage; Cerebral Vasospasm; Delayed Cerebral Ischemia

Keywords

CT perfusion; Subarachnoid hemorrhage; Vasospasm; Delayed cerebral ischemia

Outcome Measures

Primary Outcomes (3)

• Cerebral blood flow (CBF) on Admission

  Cerebral blood flow (CBF) on Admission in units of ml/100 gram brain tissue/ minute. The measurements will be compared with the outcome of the patient (namely monitoring delayed cerebral ischemia in SAH patients) to test if early CT perfusion could predict the poor outcome in SAH patients.

  3 days from the attack

• Cerebral blood volume (CBV) on Admission

  Cerebral blood volume (CBF) on Admission in units of ml/100 gram brain tissue.

  3 days from the attack

• Mean transit time (MTT) on Admission

  Mean transit time (MTT) on Admission in units of seconds.

  3 days from the attack

Secondary Outcomes (3)

• Correlation of vasospasm to perfusion abnormality using Comparing between CT angiography and CT perfusion in patients with subarachnoid hemorrhage

  4-14 days from the attack

• Hunt and Hess scale

  3 days from the attack

• Fisher scale

  3 days from the attack

Study Arms (2)

Patients with poor outcome

Follow up of patients is done for 21 days by combined clinical and radiological examination. Poor clinical outcome is associated with vasospasm leading to permanent neurological deficit, stroke or death.

Patients without poor outcome

Patients who do not develop delayed cerebral ischemia or stroke, confirmed by combined clinical and radiological examination.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients having subarachnoid hemorrhage whether post aneurysmal or spontaneous

You may qualify if:

• All patients presented with subarachnoid haemorrhage

You may not qualify if:

• Patients with abnormal renal functions with creatinine ≥ 2 mg/dl/
• Patients with hypersensitivity to contrast media.
• Contraindication to radiation as pregnancy.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Mohamed Abdel-Tawab Mohamed

Asyut, 71511, Egypt

Location

Related Publications (5)

• Aralasmak A, Akyuz M, Ozkaynak C, Sindel T, Tuncer R. CT angiography and perfusion imaging in patients with subarachnoid hemorrhage: correlation of vasospasm to perfusion abnormality. Neuroradiology. 2009 Feb;51(2):85-93. doi: 10.1007/s00234-008-0466-7. Epub 2008 Oct 11.

  PMID: 18850093 BACKGROUND

• Binaghi S, Colleoni ML, Maeder P, Uske A, Regli L, Dehdashti AR, Schnyder P, Meuli R. CT angiography and perfusion CT in cerebral vasospasm after subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2007 Apr;28(4):750-8.

  PMID: 17416833 BACKGROUND

• Dankbaar JW, de Rooij NK, Rijsdijk M, Velthuis BK, Frijns CJ, Rinkel GJ, van der Schaaf IC. Diagnostic threshold values of cerebral perfusion measured with computed tomography for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Stroke. 2010 Sep;41(9):1927-32. doi: 10.1161/STROKEAHA.109.574392. Epub 2010 Aug 5.

  PMID: 20689085 BACKGROUND

• Munoz-Guillen NM, Leon-Lopez R, Tunez-Finana I, Cano-Sanchez A. From vasospasm to early brain injury: new frontiers in subarachnoid haemorrhage research. Neurologia. 2013 Jun;28(5):309-16. doi: 10.1016/j.nrl.2011.10.015. Epub 2012 Jan 21. English, Spanish.

  PMID: 22264777 BACKGROUND

• Wintermark M, Sincic R, Sridhar D, Chien JD. Cerebral perfusion CT: technique and clinical applications. J Neuroradiol. 2008 Dec;35(5):253-60. doi: 10.1016/j.neurad.2008.03.005. Epub 2008 May 7.

  PMID: 18466974 BACKGROUND

MeSH Terms

Conditions

Subarachnoid Hemorrhage; Vasospasm, Intracranial

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Mohamed Abdel-Tawab

  Assiut University

  PRINCIPAL INVESTIGATOR

• Afaf A. Hasan, Profosser

  Assiut University

  STUDY CHAIR

• Mohamed A. Ahmed, Professor

  Assiut University

  STUDY DIRECTOR

• Hany M. Seif, Professor

  Assiut University

  STUDY DIRECTOR

• Hazem A. Youssef, Professor

  Assiut unviersity

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 21 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer

Study Record Dates

• First Submitted: June 29, 2017
• First Posted: July 11, 2017
• Study Start: March 1, 2016
• Primary Completion: February 1, 2018
• Study Completion: February 28, 2018
• Last Updated: September 16, 2021

Record last verified: 2021-09

Locations

EG (1)