Patient-ventilator Asynchrony in Patients With Brain Injury

NCT03212482 | Completed

• 1 other identifier: KY 2017-028-02
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Mechanical ventilation is an important support strategy for critically ill patients. It could improve gas exchange, reduce the work of breathing, and improve patient comfort. However, patient-ventilator asynchrony, which defined as a mismatch between the patient and ventilator may obfuscate these goals. Studies have shown that a high incidence of asynchrony (asynchrony index \> 10%) is associated with prolonged mechanical ventilation and ICU length of stay and high mortality. So far, there have been only a few studies on the epidemiology of asynchrony in brain-injured patients. Investigators conduct a prospective observational study among brain-injured patients to determine the prevalence, risk factors and outcomes of patient-ventilator asynchrony. Esophageal pressure monitoring, a surrogate for pleural pressure, combined with airway pressure and flow waveforms is used to detect patient-ventilator asynchrony.

Conditions

Brain Injuries; Mechanical Ventilation

Keywords

brain-injured patients, patient-ventilator asychrony

Outcome Measures

Primary Outcomes (1)

• The incidence of patient-ventilator asynchrony in brain-injured patients

  The incidence of different types of patient-ventilator asynchrony in brain-injured patients.

  Three days

Secondary Outcomes (1)

• The risk factors of patient-ventilator asynchrony in brain-injured patients

  Three days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with brain injury and receiving MV for at least 72 hours in the intensive care unit, will be enrolled in the study.

You may qualify if:

• \) \]older than 18 years 2) with brain injury in the ICU 3) mechanical ventilated for at least 72 hours

You may not qualify if:

• \) ICU length of stay less than 24 hours 2) enrolled in another trial

Sponsors & Collaborators

• Jian-Xin Zhou: lead

Study Sites (1)

Jian-Xin Zhou

Beijing, Beijing Municipality, 100050, China

Location

Related Publications (1)

• Luo XY, He X, Zhou YM, Wang YM, Chen JR, Chen GQ, Li HL, Yang YL, Zhang L, Zhou JX. Patient-ventilator asynchrony in acute brain-injured patients: a prospective observational study. Ann Intensive Care. 2020 Oct 19;10(1):144. doi: 10.1186/s13613-020-00763-8.

  PMID: 33074406 DERIVED

MeSH Terms

Conditions

Brain Injuries

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Officials

• Jian-Xin Zhou, MD

  Acute Brain Injury and Critical Care Research Collaboration, ABC Research Collaboration

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Doctoral Student Supervisor， chief of the department and Deputy Dean of the hospital

Study Record Dates

• First Submitted: July 4, 2017
• First Posted: July 11, 2017
• Study Start: June 15, 2017
• Primary Completion: July 1, 2019
• Study Completion: February 29, 2020
• Last Updated: May 29, 2020

Record last verified: 2020-05

Locations

CN (1)