Multi Center Case Control Study on Multiple Risk Factors of Aplastic Anemia

NCT03208647 | Completed

• 1 other identifier: MCS-EDC-1802
• Study Type: observational
• Target: 1,802
• Locations: 0 countries
• Sites: N/A

Brief Summary

To ascertain the risk factors of AA in ZheJiang Province of China at the moment, especially the comprehensive multiple factors risks. The author conducted a case-control research included 338 AA cases and 1464 controls. Subjects were surveyed using same standard questionnaire including personal data, past histories of diseases, family history and histories of occupational and daily exposure to harmful substances. Single and multiple Logistic regression analyses were made using SPSS17.0 on the dates to study potential factors in the development of AA.

Conditions

Aplastic Anemia

Keywords

case-control study; Multiple risk factors

Outcome Measures

Primary Outcomes (1)

• the items about daily Exposures

  Whether living or working near chemical factory or ionizing radiation, whether living in newly decorated apartments/house, having pets/livestock

  January 2014

Secondary Outcomes (4)

• Individual Behaviours

  January 2014

• Occupational Exposures

  January 2014

• Individual Health Status

  January 2014

• Family disease history

  January 2014

Study Arms (2)

AA Group

All the patients of AA group met a AA diagnostic criteria；

Other: AA or not

Control Group

The control group were chosen from other departments who were under acute infection (such as pneumonia), acute abdominal emergency (such as appendicitis), cataract surgery;

Interventions

AA or not OTHER

to study their risk factors

AA Group

Eligibility Criteria

• Age: 1 Year - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All the patients of AA group met a AA diagnostic criteria；The control group were chosen from other departments who were under acute infection (such as pneumonia), acute abdominal emergency (such as appendicitis), cataract surgery; All cases had no history of tumor and radiation and chemotherapy, without receiving the immunological therapy; the control group cases without hematological diseases, autoimmune diseases, Fanconi anemia, congenital diseases, etc.

You may qualify if:

• All the patients of AA group met a AA diagnostic criteria；The control group were chosen from other departments who were under acute infection (such as pneumonia), acute abdominal emergency (such as appendicitis), cataract surgery;
• years old, male or female;
• Sign the informed consent.

You may not qualify if:

• With myelodysplastic syndrome, leukaemia, multiple myeloma,megaloblastic anaemia, paroxysmal sleep hemoglobinuria disease blood disease, etc.
• History of tumor, radiation or chemotherapy, once accept the immunological therapy, autoimmune diseases or allergic disease patients;
• Patients with neurological diseases.

Sponsors & Collaborators

• Shengyun Lin: lead

MeSH Terms

Conditions

Anemia, Aplastic

Interventions

Nuclear Receptor Subfamily 4, Group A, Member 2

Condition Hierarchy (Ancestors)

Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Bone Marrow Failure Disorders; Bone Marrow Diseases

Intervention Hierarchy (Ancestors)

Orphan Nuclear Receptors; DNA-Binding Proteins; Proteins; Amino Acids, Peptides, and Proteins; Receptors, Cytoplasmic and Nuclear

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: chief

Study Record Dates

• First Submitted: July 18, 2016
• First Posted: July 5, 2017
• Study Start: January 1, 2003
• Primary Completion: January 1, 2014
• Study Completion: January 1, 2014
• Last Updated: July 5, 2017

Record last verified: 2017-07

Data Sharing

• IPD Sharing: Will not share