Effect of 4 Weeks Fish Oil Supplementation on Cycling Performance in Healthy Male Cyclists

NCT03205241 | Completed

• 1 other identifier: R14-P72
• Study Type: interventional
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

Research Plan Eleven trained cyclists have completed 4 cycling performance trials, before and after 4 weeks of fish oil supplementation and before and after 4 weeks of placebo with a 4 week washout between supplementation periods. During the performance trials blood, expired air and heart rate were collected. The blood samples have been used to investigate the production of inflammation resulting from the cycling performance test. Inflammation has been assessed using enzyme-linked immunosorbent assay for IL-6, which is an inflammatory cytokine. Work done from the cycling performance will be analysed to investigate whether there is a relationship with power and inflammation and whether this is modulated by fish oil supplementation. Specific Aims

1. 1.Does 4 weeks of Fish Oil supplementation attenuate the inflammatory response following high intensity cycling.
2. 2.Is a modulation of the inflammatory response connected to cycling performance.
3. 3.Four weeks of n3-PUFA supplementation will reduce the inflammatory response
4. 4.A reduction in inflammation will improve cycling performance

Conditions

Exercise-induced Inflammation

Keywords

Exercise; Fish Oil; Cycling; Inflammation; Oxidative stress

Outcome Measures

Primary Outcomes (1)

• Work Done

  Work done measured in Joules from the Lode cycle ergometer during 15 minute cycling time trial

  15 minutes during time trial

Study Arms (2)

n-3 PUFA

EXPERIMENTAL

Omega-3 polyunsaturated fatty acid - 5.7g/ day for 4 weeks

Dietary Supplement: n-3 PUFA

Placebo

PLACEBO COMPARATOR

Olive Oil - 6g/ day for 4 weeks

Dietary Supplement: Placebo

Interventions

n-3 PUFA DIETARY_SUPPLEMENT

n-3 PUFA capsules containing EPA and DHA

Also known as: Fish Oil supplementation, Omega-3

n-3 PUFA

Placebo DIETARY_SUPPLEMENT

Olive oil capsules

Also known as: Olive Oil

Placebo

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• recreationally trained male cyclists

You may not qualify if:

• History of coagulation/bleeding disorder
• History of metabolic disease
• Serious allergy
• History of heart disease
• Regular use of anti-inflammatory drugs
• Vitamin or fish oil supplementation over the past 6 months
• Known to have blood-borne virus
• Females

Sponsors & Collaborators

• Loughborough University: lead
• University of Worcester: collaborator

MeSH Terms

Conditions

Motor Activity; Inflammation

Interventions

Fatty Acids, Omega-3; Docosahexaenoic Acids; Olive Oil

Condition Hierarchy (Ancestors)

Behavior; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Dietary Fats, Unsaturated; Dietary Fats; Fats; Lipids; Fatty Acids, Unsaturated; Fatty Acids; Fish Oils; Oils; Fats, Unsaturated; Plant Oils; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Lynsey S Wilson, MSc

  Loughborough University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Technical Tutor in Exercise Physiology

Model Details: Randomised, placebo-controlled, double blind, crossover design study

Study Record Dates

• First Submitted: June 28, 2017
• First Posted: July 2, 2017
• Study Start: April 1, 2014
• Primary Completion: December 1, 2014
• Study Completion: December 1, 2014
• Last Updated: July 2, 2017

Record last verified: 2017-06

Data Sharing

• IPD Sharing: Will not share