Children's Surgery in Sub-Saharan Africa

NCT03185637 | Completed

• 1 other identifier: PSA2016/7
• Study Type: observational
• Target: 1,407
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Five billion people worldwide do not have access to safe, affordable surgical care. A significant proportion live in sub-Saharan Africa (SSA), where up to 50% of the population are children. There is limited literature on neonatal and paediatric surgery in SSA and children's surgery does not appear on any of the National Health Strategic Plans for the 47 independent countries across SSA. Objectives: To form a collaboration of surgeons and allied health professionals involved in children's surgery across SSA and collectively undertake the largest prospective cohort study of paediatric surgery in this region. Materials and Methods: Data will be collected via REDCap website on all patients with gastroschisis, anorectal malformation, appendicitis, inguinal hernia and intussusception, during a 1-month period of collaborators choice between October 2016 to April 2017, with a 30-day follow up until the end of May 2017. Estimated study population: 1450 patients from 50 institutions. Full ethical approval has been granted by the host centre; local ethical approval will be required at collaborating centres for participation. All collaborators will be co-authors. Primary outcome will be in-hospital all-cause mortality. Secondary outcomes will include post-intervention complications. Data will be collected on institutional facilities, patient demographics, duration from condition onset to presentation, peri-operative resuscitation, intervention and outcome. Differences in outcomes between SSA and benchmark data from high-income countries will be calculated using chi-squared analysis. Multi-level multivariate logistic regression analysis will be used to identify interventions and peri-operative factors associated with improved outcomes; p\<0.05 will be deemed significant. Outcome: Results will be used to advocate for enhanced children's surgical services in SSA. We shall identify context-appropriate interventions associated with improved outcome. The collaboration will help to enhance research capacity in the region.

Conditions

Gastroschisis; Anorectal Malformation; Appendicitis; Intussusception; Inguinal Hernia

Keywords

Outcomes; Mortality; Complications; Neonatal surgery; Paediatric surgery; Childrens surgery; Sub-Saharan Africa; Research Collaboration; Gastroschisis; Anorectal malformation; Appendicitis; Intussuception; Inguinal hernia

Outcome Measures

Primary Outcomes (1)

• All-cause in-hospital mortality

  In-hospital (if in the patient is still in hospital at 30-days post-intervention, a 30-day mortality will be utilised)

Secondary Outcomes (5)

• 30-day mortality

  30-days

• Duration of hospital stay

  Patients are followed up for a maximum of 30-days post-intervention

• Surgical site infection

  Within 30-days post-intervention

• Full thickness wound dehiscence

  Within 30-days post-intervention

• Need for re-intervention

  Within 30-days of the primary intervention

Study Arms (5)

Gastroschisis

All patients presenting primarily to the institution with gastroschisis during the data collection period will be included in the study.

Procedure: Various interventions for each of the conditions.

Anorectal malformation

All patients presenting primarily to the institution with anorectal malformation during the data collection period will be included in the study.

Procedure: Various interventions for each of the conditions.

Appendicitis

All patients under 16-years of age presenting primarily to the institution with appendicitis during the data collection period will be included in the study.

Procedure: Various interventions for each of the conditions.

Intussusception

All patients under 16-years of age presenting primarily to the institution with intussusception during the data collection period will be included in the study.

Procedure: Various interventions for each of the conditions.

Inguinal hernia

All patients under 16-years of age undergoing surgery for an inguinal hernia at the institution during the data collection period will be included in the study.

Procedure: Various interventions for each of the conditions.

Interventions

Various interventions for each of the conditions. PROCEDURE

This is an observational study. Patients were not allocated to different interventions. Common interventions for each of the conditions, which will be compared during analysis include the following: Gastroschisis - primary operative closure, surgical silo, preformed silo. Anorectal malformation - various types of stoma, anoplasty, PSARP, other. Appendicitis - antibiotics, open appendicectomy, laparoscopic appendicectomy. Intussusception - air enema reduction, hydro-enema reduction, laparotomy. Inguinal hernia - open repair, laparoscopic repair.

Anorectal malformation; Appendicitis; Gastroschisis; Inguinal hernia; Intussusception

Eligibility Criteria

• Age: Up to 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Collaborating centres were recruited using convenience sampling with snowballing. Centres include both tertiary paediatric surgery centres and district hospitals.

You may qualify if:

• All patients under 16-years of age presenting primarily with one of the five study conditions during the data collection period. This includes those managed conservatively without surgery or intervention and those offered palliative care, except patients with an inguinal hernia who must receive surgery to be included.

You may not qualify if:

• Patients re-presenting with one of the five study conditions with a complication from a previous intervention or requiring further surgical intervention.

Sponsors & Collaborators

• King's College London: lead
• Sylvanus Olympio University Teaching Hospital, Lome, Togo.: collaborator
• National Hospital of Niamey: collaborator
• Centre Hospitalier Universitaire de la Mère et de l Enfant, Cotonou, Benin.: collaborator
• HEAL Africa Hospital, Goma, Democratic Republic of the Congo.: collaborator
• Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle: collaborator
• University Hospital De Bouaké, Ivory Coast.: collaborator
• Teaching Hospital Treichville, Abidjan, Ivory Coast.: collaborator
• Harare Central Hospital, Zimbabwe.: collaborator
• University Teaching Hospital, Lusaka, Zambia: collaborator
• Mulago Hospital, Uganda: collaborator
• Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.: collaborator
• Mbingo Baptist Hospital, Cameroon.: collaborator
• Ministry of Health, Ghana: collaborator
• Korle-Bu Teaching Hospital, Accra, Ghana: collaborator
• Edna Adan Maternity Hospital, Hargeisa, Somaliland.: collaborator
• Embu Level 5 Hospital, Kenya.: collaborator
• Tenwek Hospital: collaborator
• Soba University Hospital: collaborator
• Kamuzu Central Hospital: collaborator
• Queen Elizabeth Central Hospital, Blantyre, Malawi: collaborator
• Muhimbili National Hospital, Dar es Salaam, Tanzania.: collaborator
• Grey's Hospital: collaborator
• Stranger Hospital, Kwazulu-Natal, South Africa.: collaborator
• Tygerberg Hospital, South Africa.: collaborator
• Clinton Hospital, Johannesburg: collaborator
• Charlotte Maxeke Johannesburg Academic Hospital: collaborator
• Chris Hani Baragwanath Academic Hospital: collaborator
• East London Hospital Complex, South Africa.: collaborator
• Red Cross War Memorial Childrens Hospital: collaborator
• Delta State University Teaching Hospital Ogharra: collaborator
• Bowen University Teaching Hospital, Ogbomoso: collaborator
• Ondo State Trauma and Surgical Centre: collaborator
• Mnamdi Azikiwe University Teaching Hospital: collaborator
• University Of Nigeria Teaching Hospital: collaborator
• University of Port Harcourt Teaching Hospital: collaborator
• University College Hospital, Ibadan: collaborator
• Ahmadu Bello University Teaching Hospital: collaborator
• University of Abuja Teaching Hospital: collaborator
• National Hospital, Abuja: collaborator
• University of Calabar Teaching Hospital: collaborator
• Federal Medical Centre, Abeokuta: collaborator
• Federal Medical Centre, Owo: collaborator
• Benue State University Teaching Hospital: collaborator
• Olabisi Onabanjo University Teaching Hospital: collaborator
• University of Ilorin Teaching Hospital: collaborator
• Federal Medical Centre Lokoja: collaborator
• Lagos State University: collaborator
• Obafemi Awolowo University Teaching Hospital: collaborator
• Aminu Kano Teaching Hospital: collaborator

Study Sites (1)

King's Centre for Global Health and Health Partnerships

Denmark Hill, London, SE5 9RJ, United Kingdom

Location

Related Publications (80)

• GlobalSurg Collaborative. Mortality of emergency abdominal surgery in high-, middle- and low-income countries. Br J Surg. 2016 Jul;103(8):971-988. doi: 10.1002/bjs.10151. Epub 2016 May 4.

  PMID: 27145169 BACKGROUND

• Poenaru D, Pemberton J, Frankfurter C, Cameron BH. Quantifying the Disability from Congenital Anomalies Averted Through Pediatric Surgery: A Cross-Sectional Comparison of a Pediatric Surgical Unit in Kenya and Canada. World J Surg. 2015 Sep;39(9):2198-206. doi: 10.1007/s00268-015-3103-8.

  PMID: 26037026 BACKGROUND

• Price R, Makasa E, Hollands M. World Health Assembly Resolution WHA68.15: "Strengthening Emergency and Essential Surgical Care and Anesthesia as a Component of Universal Health Coverage"-Addressing the Public Health Gaps Arising from Lack of Safe, Affordable and Accessible Surgical and Anesthetic Services. World J Surg. 2015 Sep;39(9):2115-25. doi: 10.1007/s00268-015-3153-y.

  PMID: 26239773 BACKGROUND

• Ekenze SO, Ajuzieogu OV, Nwomeh BC. Challenges of management and outcome of neonatal surgery in Africa: a systematic review. Pediatr Surg Int. 2016 Mar;32(3):291-9. doi: 10.1007/s00383-016-3861-x. Epub 2016 Jan 18.

  PMID: 26783085 BACKGROUND

• Bradnock TJ, Marven S, Owen A, Johnson P, Kurinczuk JJ, Spark P, Draper ES, Knight M; BAPS-CASS. Gastroschisis: one year outcomes from national cohort study. BMJ. 2011 Nov 15;343:d6749. doi: 10.1136/bmj.d6749.

  PMID: 22089731 BACKGROUND

• Ademola TO, Oludayo SA, Samuel OA, Amarachukwu EC, Akinwunmi KO, Olusanya A. Clinicopathological review of 156 appendicectomies for acute appendicitis in children in Ile-Ife, Nigeria: a retrospective analysis. BMC Emerg Med. 2015 May 9;15:7. doi: 10.1186/s12873-015-0030-9.

  PMID: 25956068 BACKGROUND

• Hadley GP. Intra-abdominal sepsis--epidemiology, aetiology and management. Semin Pediatr Surg. 2014 Dec;23(6):357-62. doi: 10.1053/j.sempedsurg.2014.06.008. Epub 2014 Jun 4.

  PMID: 25459442 BACKGROUND

• Ameh EA, Abantanga FA, Birabwa-Male D. Surgical aspects of bacterial infection in African children. Semin Pediatr Surg. 2012 May;21(2):116-24. doi: 10.1053/j.sempedsurg.2012.01.004.

  PMID: 22475117 BACKGROUND

• Bamigbola KT, Nasir AA, Abdur-Rahman LO, Adeniran JO. Complicated childhood inguinal hernias in UITH, Ilorin. Afr J Paediatr Surg. 2012 Sep-Dec;9(3):227-30. doi: 10.4103/0189-6725.104725.

  PMID: 23250245 BACKGROUND

• Mabiala-Babela JR, Pandzou N, Koutaba E, Ganga-Zandzou S, Senga P. [Retrospective study of visceral surgical emergencies in children at the University Hospital Center of Brazzaville (Congo)]. Med Trop (Mars). 2006 Apr;66(2):172-6. French.

  PMID: 16775942 BACKGROUND

• Jiang J, Jiang B, Parashar U, Nguyen T, Bines J, Patel MM. Childhood intussusception: a literature review. PLoS One. 2013 Jul 22;8(7):e68482. doi: 10.1371/journal.pone.0068482. Print 2013.

  PMID: 23894308 BACKGROUND

• Eeson G, Birabwa-Male D, Pennington M, Blair GK. Costs and cost-effectiveness of pediatric inguinal hernia repair in Uganda. World J Surg. 2015 Feb;39(2):343-9. doi: 10.1007/s00268-014-2818-2.

  PMID: 25270348 BACKGROUND

• Citron I, Chokotho L, Lavy C. Prioritisation of surgery in the National Health Strategic Plans of Africa: a systematic review. Lancet. 2015 Apr 27;385 Suppl 2:S53. doi: 10.1016/S0140-6736(15)60848-0. Epub 2015 Apr 26.

  PMID: 26313103 BACKGROUND

• Agugua NE, Nwako FA. Gastroschisis a fifteen-year experience. West Afr J Med. 1990 Apr-Jun;9(2):147-50.

  PMID: 2148495 BACKGROUND

• Arnold M. Is the incidence of gastroschisis rising in South Africa in accordance with international trends? A retrospective analysis at Pretoria Academic and Kalafong Hospitals, 1981-2001. S Afr J Surg. 2004 Aug;42(3):86-8.

  PMID: 15532615 BACKGROUND

• Wright NJ, Zani A, Ade-Ajayi N. Epidemiology, management and outcome of gastroschisis in Sub-Saharan Africa: Results of an international survey. Afr J Paediatr Surg. 2015 Jan-Mar;12(1):1-6. doi: 10.4103/0189-6725.150924.

  PMID: 25659541 BACKGROUND

• Ford K, Poenaru D, Moulot O, Tavener K, Bradley S, Bankole R, Tshifularo N, Ameh E, Alema N, Borgstein E, Hickey A, Ade-Ajayi N. Gastroschisis: Bellwether for neonatal surgery capacity in low resource settings? J Pediatr Surg. 2016 Aug;51(8):1262-7. doi: 10.1016/j.jpedsurg.2016.02.090. Epub 2016 Mar 12.

  PMID: 27032610 BACKGROUND

• Iliff PJ. Neonatal surgery in Harare Hospital. Cent Afr J Med. 1990 Jan;36(1):11-5.

  PMID: 2397493 BACKGROUND

• Apfeld JC, Wren SM, Macheka N, Mbuwayesango BA, Bruzoni M, Sylvester KG, Kastenberg ZJ. Infant, maternal, and geographic factors influencing gastroschisis related mortality in Zimbabwe. Surgery. 2015 Dec;158(6):1475-80. doi: 10.1016/j.surg.2015.04.037. Epub 2015 Jun 11.

  PMID: 26071924 BACKGROUND

• Abdur-Rahman LO, Abdulrasheed NA, Adeniran JO. Challenges and outcomes of management of anterior abdominal wall defects in a Nigerian tertiary hospital. Afr J Paediatr Surg. 2011 May-Aug;8(2):159-63. doi: 10.4103/0189-6725.86053.

  PMID: 22005356 BACKGROUND

• Sekabira J, Hadley GP. Gastroschisis: a third world perspective. Pediatr Surg Int. 2009 Apr;25(4):327-9. doi: 10.1007/s00383-009-2348-4. Epub 2009 Mar 14.

  PMID: 19288118 BACKGROUND

• Davies MR, Beale PG. The pivotal role of the surgeon in the results achieved in gastroschisis. Pediatr Surg Int. 1996 Mar;11(2-3):82-5. doi: 10.1007/BF00183731.

  PMID: 24057522 BACKGROUND

• Zani A, Ruttenstock E, Davenport M, Ade-Ajayi N. Is there unity in Europe? First survey of EUPSA delegates on the management of gastroschisis. Eur J Pediatr Surg. 2013 Feb;23(1):19-24. doi: 10.1055/s-0032-1326954. Epub 2012 Oct 23.

  PMID: 23093440 BACKGROUND

• Weil BR, Leys CM, Rescorla FJ. The jury is still out: changes in gastroschisis management over the last decade are associated with both benefits and shortcomings. J Pediatr Surg. 2012 Jan;47(1):119-24. doi: 10.1016/j.jpedsurg.2011.10.029.

  PMID: 22244403 BACKGROUND

• Pastor AC, Phillips JD, Fenton SJ, Meyers RL, Lamm AW, Raval MV, Lehman E, Karp TB, Wales PW, Langer JC. Routine use of a SILASTIC spring-loaded silo for infants with gastroschisis: a multicenter randomized controlled trial. J Pediatr Surg. 2008 Oct;43(10):1807-12. doi: 10.1016/j.jpedsurg.2008.04.003.

  PMID: 18926212 BACKGROUND

• Kunz SN, Tieder JS, Whitlock K, Jackson JC, Avansino JR. Primary fascial closure versus staged closure with silo in patients with gastroschisis: a meta-analysis. J Pediatr Surg. 2013 Apr;48(4):845-57. doi: 10.1016/j.jpedsurg.2013.01.020.

  PMID: 23583145 BACKGROUND

• Theron A, Loveland J. Birth prevalence of anorectal malformation in the referral area for the University of the Witwatersrand tertiary hospitals, South Africa. Eur J Pediatr Surg. 2015 Apr;25(2):220-5. doi: 10.1055/s-0033-1360456. Epub 2014 Feb 10.

  PMID: 24515733 BACKGROUND

• Safavi A, Skarsgard E, Butterworth S. Bowel-defect disproportion in gastroschisis: does the need to extend the fascial defect predict outcome? Pediatr Surg Int. 2012 May;28(5):495-500. doi: 10.1007/s00383-012-3055-0. Epub 2012 Feb 14.

  PMID: 22331201 BACKGROUND

• Govender S, Wiersma R. Delayed diagnosis of anorectal malformations (ARM): causes and consequences in a resource-constrained environment. Pediatr Surg Int. 2016 Apr;32(4):369-75. doi: 10.1007/s00383-016-3866-5. Epub 2016 Jan 20.

  PMID: 26790675 BACKGROUND

• Kigo CN, Ndung'u JM. Bowel function following primary repair of anorectal malformations at Kenyatta National Hospital. East Afr Med J. 2002 Mar;79(3):124-7. doi: 10.4314/eamj.v79i3.8889.

  PMID: 12389955 BACKGROUND

• Chirdan LB, Uba FA, Ameh EA, Mshelbwala PM. Colostomy for high anorectal malformation: an evaluation of morbidity and mortality in a developing country. Pediatr Surg Int. 2008 Apr;24(4):407-10. doi: 10.1007/s00383-008-2114-z. Epub 2008 Feb 13.

  PMID: 18270719 BACKGROUND

• Lawal TA, Olulana DI, Ogundoyin OO. Spectrum of colorectal surgery operations performed in a single paediatric surgery unit in sub-Saharan Africa. Afr J Paediatr Surg. 2014 Apr-Jun;11(2):128-31. doi: 10.4103/0189-6725.132802.

  PMID: 24841012 BACKGROUND

• Olivieri C, Belay K, Coletta R, Retrosi G, Molle P, Calisti A. Preventing posterior sagittal anoplasty 'cripples' in areas with limited medical resources: a few modifications to surgical approach in anorectal malformations. Afr J Paediatr Surg. 2012 Sep-Dec;9(3):223-6. doi: 10.4103/0189-6725.104724.

  PMID: 23250244 BACKGROUND

• Nandi B, Mungongo C, Lakhoo K. A comparison of neonatal surgical admissions between two linked surgical departments in Africa and Europe. Pediatr Surg Int. 2008 Aug;24(8):939-42. doi: 10.1007/s00383-008-2177-x. Epub 2008 Jun 14.

  PMID: 18553088 BACKGROUND

• Adeyemo AA, Gbadegesin RA, Omotade OO. Major congenital malformations among neonatal referrals to a Nigerian university hospital. East Afr Med J. 1997 Nov;74(11):699-701.

  PMID: 9557439 BACKGROUND

• Ameh EA, Chirdan LB. Neonatal intestinal obstruction in Zaria, Nigeria. East Afr Med J. 2000 Sep;77(9):510-3. doi: 10.4314/eamj.v77i9.46702.

  PMID: 12862145 BACKGROUND

• Shah M, Gallaher J, Msiska N, McLean SE, Charles AG. Pediatric intestinal obstruction in Malawi: characteristics and outcomes. Am J Surg. 2016 Apr;211(4):722-6. doi: 10.1016/j.amjsurg.2015.11.024. Epub 2016 Jan 6.

  PMID: 26810940 BACKGROUND

• Rintala RJ, Pakarinen MP. Imperforate anus: long- and short-term outcome. Semin Pediatr Surg. 2008 May;17(2):79-89. doi: 10.1053/j.sempedsurg.2008.02.003.

  PMID: 18395657 BACKGROUND

• Lukong CS, Ameh EA, Mshelbwala PM, Jabo BA, Gomna A, Akiniyi OT, Nmadu PT. Management of anorectal malformation: Changing trend over two decades in Zaria, Nigeria. Afr J Paediatr Surg. 2011 Jan-Apr;8(1):19-22. doi: 10.4103/0189-6725.78663.

  PMID: 21478581 BACKGROUND

• Osifo OD, Osagie TO, Udefiagbon EO. Outcome of primary posterior sagittal anorectoplasty of high anorectal malformation in well selected neonates. Niger J Clin Pract. 2014 Jan-Feb;17(1):1-5. doi: 10.4103/1119-3077.122821.

  PMID: 24326797 BACKGROUND

• Poenaru D, Borgstein E, Numanoglu A, Azzie G. Caring for children with colorectal disease in the context of limited resources. Semin Pediatr Surg. 2010 May;19(2):118-27. doi: 10.1053/j.sempedsurg.2009.11.017.

  PMID: 20307848 BACKGROUND

• Derbew M, Ahmed E. The pattern of pediatric surgical conditions in Tikur Anbessa Unversity Hospital, Addis Ababa, Ethiopia. Ethiop Med J. 2006 Oct;44(4):331-8.

  PMID: 17370432 BACKGROUND

• Momoh JT. External hernia in Nigerian children. Ann Trop Paediatr. 1985 Dec;5(4):197-200. doi: 10.1080/02724936.1985.11748392.

  PMID: 2418768 BACKGROUND

• Daniel E, Mersha D. Childhood appendicitis: factors associated with its incidence and perforation in Ethiopian children. Ethiop Med J. 1991 Jan;29(1):15-9.

  PMID: 2001686 BACKGROUND

• Ein SH, Njere I, Ein A. Six thousand three hundred sixty-one pediatric inguinal hernias: a 35-year review. J Pediatr Surg. 2006 May;41(5):980-6. doi: 10.1016/j.jpedsurg.2006.01.020.

  PMID: 16677897 BACKGROUND

• Ohene-Yeboah M, Abantanga FA. Inguinal hernia disease in Africa: a common but neglected surgical condition. West Afr J Med. 2011 Mar-Apr;30(2):77-83.

  PMID: 21984452 BACKGROUND

• Zamakhshary M, To T, Guan J, Langer JC. Risk of incarceration of inguinal hernia among infants and young children awaiting elective surgery. CMAJ. 2008 Nov 4;179(10):1001-5. doi: 10.1503/cmaj.070923.

  PMID: 18981440 BACKGROUND

• Erdogan D, Karaman I, Aslan MK, Karaman A, Cavusoglu YH. Analysis of 3,776 pediatric inguinal hernia and hydrocele cases in a tertiary center. J Pediatr Surg. 2013 Aug;48(8):1767-72. doi: 10.1016/j.jpedsurg.2012.09.048.

  PMID: 23932620 BACKGROUND

• Ameh EA. Morbidity and mortality of inguinal hernia in the newborn. Niger Postgrad Med J. 2002 Dec;9(4):233-4.

  PMID: 12690685 BACKGROUND

• Usang UE, Sowande OA, Adejuyigbe O, Bakare TI, Ademuyiwa OA. The role of preoperative antibiotics in the prevention of wound infection after day case surgery for inguinal hernia in children in Ile Ife, Nigeria. Pediatr Surg Int. 2008 Oct;24(10):1181-5. doi: 10.1007/s00383-008-2241-6. Epub 2008 Aug 23.

  PMID: 18726104 BACKGROUND

• Ogundoyin OO, Afolabi AO, Ogunlana DI, Lawal TA, Yifieyeh AC. Pattern and outcome of childhood intestinal obstruction at a tertiary hospital in Nigeria. Afr Health Sci. 2009 Sep;9(3):170-3.

  PMID: 20589146 BACKGROUND

• Stolz LA, Kizza H, Little K, Kasekende J. Intussusception detected with ultrasound in a resource-limited setting. Lancet. 2013 Jun 8;381(9882):2054. doi: 10.1016/S0140-6736(13)60690-X. No abstract available.

  PMID: 23746905 BACKGROUND

• Omore R, Osawa F, Musia J, Rha B, Ismail A, Kiulia NM, Moke F, Vulule J, Wainaina AM, Tole J, Machoki SM, Nuorti JP, Breiman RF, Parashar UD, Montgomery JM, Tate JE. Intussusception Cases Among Children Admitted to Referral Hospitals in Kenya, 2002-2013: Implications for Monitoring Postlicensure Safety of Rotavirus Vaccines in Africa. J Pediatric Infect Dis Soc. 2016 Dec;5(4):465-469. doi: 10.1093/jpids/piv051. Epub 2015 Aug 25.

  PMID: 26407281 BACKGROUND

• Talabi AO, Sowande OA, Etonyeaku CA, Adejuyigbe O. Childhood intussusception in Ile-ife: what has changed? Afr J Paediatr Surg. 2013 Jul-Sep;10(3):239-42. doi: 10.4103/0189-6725.120900.

  PMID: 24192467 BACKGROUND

• Mpabalwani EM, Chitambala P, Chibumbya JN, Matapo B, Mutambo H, Mwenda JM, Babaniyi O, Munkonge L. Intussusception incidence rates in 9 Zambian hospitals, 2007-2011: prerotavirus vaccine introduction. Pediatr Infect Dis J. 2014 Jan;33 Suppl 1:S94-8. doi: 10.1097/INF.0000000000000055.

  PMID: 24343623 BACKGROUND

• Steele AD, Patel M, Cunliffe NA, Bresee JS, Borgstein E, Parashar UD. Workshop on intussusception in African countries--meeting report. Vaccine. 2012 Apr 27;30 Suppl 1:A185-9. doi: 10.1016/j.vaccine.2011.10.004.

  PMID: 22520130 BACKGROUND

• Moore SW, Kirsten M, Muller EW, Numanoglu A, Chitnis M, Le Grange E, Banieghbal B, Hadley GP. Retrospective surveillance of intussusception in South Africa, 1998-2003. J Infect Dis. 2010 Sep 1;202 Suppl:S156-61. doi: 10.1086/653563.

  PMID: 20684696 BACKGROUND

• Abantanga FA, Amoah M, Adeyinka AO, Nimako B, Yankey KP. Pneumatic reduction of intussusception in children at the Komfo Anokye Hospital, Kumasi, Ghana. East Afr Med J. 2008 Nov;85(11):550-5. doi: 10.4314/eamj.v85i11.9672.

  PMID: 19413208 BACKGROUND

• Kuremu RT. Childhood intussusception at the Moi teaching and Referral Hospital Eldoret: management challenges in a rural setting. East Afr Med J. 2004 Sep;81(9):443-6. doi: 10.4314/eamj.v81i9.9218.

  PMID: 15626052 BACKGROUND

• Carneiro PM, Kisusi DM. Intussusception in children seen at Muhimbili National Hospital, Dar es Salaam. East Afr Med J. 2004 Sep;81(9):439-42. doi: 10.4314/eamj.v81i9.9217.

  PMID: 15626051 BACKGROUND

• Edino ST, Ochicha O, Mohammed AZ, Anumah M. Intussusception in Kano: a 5-year analysis of pattern, morbidity and mortality. Niger J Med. 2003 Oct-Dec;12(4):221-4.

  PMID: 14768198 BACKGROUND

• Ameh EA. The morbidity and mortality of right hemicolectomy for complicated intussusception in infants. Niger Postgrad Med J. 2002 Sep;9(3):123-4.

  PMID: 12501272 BACKGROUND

• Ameh EA. The morbidity and mortality of laparotomy for uncomplicated intussusception in children. West Afr J Med. 2002 Apr-Jun;21(2):115-6.

  PMID: 12403031 BACKGROUND

• Harouna Y, Tardivel G, Abdou I, Gamatie Y, Mariama S, Bia M. [Prognosis of acute intestinal intussusception in infants at the national hospital of Niamey (Niger). Eleven cases treated surgically]. Bull Soc Pathol Exot. 1997;90(1):30-2. French.

  PMID: 9264747 BACKGROUND

• Adejuyigbe O, Jeje EA, Owa JA. Childhood intussusception in Ile-Ife, Nigeria. Ann Trop Paediatr. 1991;11(2):123-7. doi: 10.1080/02724936.1991.11747490.

  PMID: 1715142 BACKGROUND

• Abdur-Rahman LO, Adeniran JO, Taiwo JO, Nasir AA, Odi T. Bowel resection in Nigerian children. Afr J Paediatr Surg. 2009 Jul-Dec;6(2):85-7. doi: 10.4103/0189-6725.54769.

  PMID: 19661636 BACKGROUND

• Ogundoyin OO, Olulana DI, Lawal TA. Childhood intussusception: A prospective study of management trend in a developing country. Afr J Paediatr Surg. 2015 Oct-Dec;12(4):217-20. doi: 10.4103/0189-6725.172541.

  PMID: 26712283 BACKGROUND

• Ekenze SO, Mgbor SO, Okwesili OR. Routine surgical intervention for childhood intussusception in a developing country. Ann Afr Med. 2010 Jan-Mar;9(1):27-30. doi: 10.4103/1596-3519.62621.

  PMID: 20418646 BACKGROUND

• Carapinha C, Truter M, Bentley A, Welthagen A, Loveland J. Factors determining clinical outcomes in intussusception in the developing world: Experience from Johannesburg, South Africa. S Afr Med J. 2016 Jan 12;106(2):177-80. doi: 10.7196/SAMJ.2016.v106i2.9672.

  PMID: 26821898 BACKGROUND

• Chalya PL, Kayange NM, Chandika AB. Childhood intussusceptions at a tertiary care hospital in northwestern Tanzania: a diagnostic and therapeutic challenge in resource-limited setting. Ital J Pediatr. 2014 Mar 11;40(1):28. doi: 10.1186/1824-7288-40-28.

  PMID: 24618338 BACKGROUND

• Khorana J, Singhavejsakul J, Ukarapol N, Laohapensang M, Wakhanrittee J, Patumanond J. Enema reduction of intussusception: the success rate of hydrostatic and pneumatic reduction. Ther Clin Risk Manag. 2015 Dec 15;11:1837-42. doi: 10.2147/TCRM.S92169. eCollection 2015.

  PMID: 26719697 BACKGROUND

• Mensah YB, Glover-Addy H, Etwire V, Twum MB, Asiamah S, Appeadu-Mensah W, Hesse AA. Pneumatic reduction of intussusception in children at Korle Bu Teaching Hospital: an initial experience. Afr J Paediatr Surg. 2011 May-Aug;8(2):176-81. doi: 10.4103/0189-6725.86057.

  PMID: 22005360 BACKGROUND

• Ahmed HM, Ahmed O, Ahmed RK. Adding a custom made pressure release valve during air enema for intussusception: A new technique. Afr J Paediatr Surg. 2015 Oct-Dec;12(4):232-5. doi: 10.4103/0189-6725.172550.

  PMID: 26712286 BACKGROUND

• Wiersma R, Hadley GP. Minimizing surgery in complicated intussusceptions in the Third World. Pediatr Surg Int. 2004 Mar;20(3):215-7. doi: 10.1007/s00383-003-1099-x. Epub 2004 Apr 3.

  PMID: 15064960 BACKGROUND

• Bhangu A, Kolias AG, Pinkney T, Hall NJ, Fitzgerald JE. Surgical research collaboratives in the UK. Lancet. 2013 Sep 28;382(9898):1091-2. doi: 10.1016/S0140-6736(13)62013-9. No abstract available.

  PMID: 24075040 BACKGROUND

• Kong VY, Sartorius B, Clarke DL. Acute appendicitis in the developing world is a morbid disease. Ann R Coll Surg Engl. 2015 Jul;97(5):390-5. doi: 10.1308/003588415X14181254790608.

  PMID: 26264094 BACKGROUND

• Ameh EA. Incarcerated and strangulated inguinal hernias in children in Zaria, Nigeria. East Afr Med J. 1999 Sep;76(9):499-501.

  PMID: 10685318 BACKGROUND

• Ohene-Yeboah M, Abantanga F, Oppong J, Togbe B, Nimako B, Amoah M, Azorliade R. Some aspects of the epidemiology of external hernias in Kumasi, Ghana. Hernia. 2009 Oct;13(5):529-32. doi: 10.1007/s10029-009-0491-4. Epub 2009 Mar 20.

  PMID: 19301084 BACKGROUND

• Healy DA, Doyle D, Moynagh E, Maguire M, Ahmed I, Ahmed AS, Caldwell M, O'Hanrahan T, Walsh SR. Systematic Review and Meta-Analysis on the Influence of Surgeon Specialization on Outcomes Following Appendicectomy in Children. Medicine (Baltimore). 2015 Aug;94(32):e1352. doi: 10.1097/MD.0000000000001352.

  PMID: 26266388 BACKGROUND

• Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009 Apr;42(2):377-81. doi: 10.1016/j.jbi.2008.08.010. Epub 2008 Sep 30.

  PMID: 18929686 BACKGROUND

MeSH Terms

Conditions

Gastroschisis; Anorectal Malformations; Appendicitis; Intussusception; Hernia, Inguinal

Condition Hierarchy (Ancestors)

Musculoskeletal Abnormalities; Musculoskeletal Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hernia, Abdominal; Hernia; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Digestive System Abnormalities; Digestive System Diseases; Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Cecal Diseases; Intestinal Diseases; Intestinal Obstruction

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 12, 2017
• First Posted: June 14, 2017
• Study Start: October 1, 2016
• Primary Completion: May 31, 2017
• Study Completion: June 30, 2017
• Last Updated: August 21, 2017

Record last verified: 2017-06

Data Sharing

• IPD Sharing: Will share

Locations

GB (1)