Opioid Consumption After Hospital Discharge in Orthopedic Surgery

NCT03185117 | Terminated

• 1 other identifier: 2016H0219
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

At the Ohio State University, and across the country, surgical patients admitted to the hospital are over-prescribed a significant amount of opioid medications upon discharge to home. Recent studies reveal that a large percentage of patients prescribed opioid medications after surgery have approximately half of the prescribed medication left over. This study aims to evaluate reported opioid use after surgery in patients undergoing major orthopedic surgery in order to better approach the issue with current opioid use and abuse trends while still providing adequate medical care and pain management to patients

Conditions

Opioid Use; Arthropathy of Knee; Arthropathy of Hip

Keywords

opioid consumption; postdischarge; major orthopedic surgery

Outcome Measures

Primary Outcomes (1)

• opioid consumption over time

  The opioid medication (oral morphine equivalent) taken by the patients will be assessed every week until the sixth postoperative week, to compare it with the amount prescribed by the physicians

  once per week, up to six weeks after surgery

Study Arms (1)

All patients

Adult patients scheduled to undergo a total knee arthroplasty or total hip arthroplasty, who give written informed consent to participate in the study.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients at the OSUMC, 18 years of age and older scheduled to undergo a total knee arthroplasty or total hip arthroplasty, who give written informed consent to participate in the study and who meet all inclusion and no exclusion criteria.

You may qualify if:

• Male or female, 18 years of age and older, undergoing orthopedic procedures (hip or knee arthroplasty)
• Capable and willing to consent
• Participants literate in English language

You may not qualify if:

• History of drug and /or alcohol abuse/ dependency
• Ketamine use during hospitalization
• Illiteracy
• Presence of a clinically diagnosed major psychiatric condition such as bipolar disorder, uncontrolled major depression, schizophrenia
• Any condition that the principle investigator may disqualify the patient

Sponsors & Collaborators

• Ohio State University: lead

Study Sites (1)

The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States

Location

Related Publications (2)

• Bartels K, Mayes LM, Dingmann C, Bullard KJ, Hopfer CJ, Binswanger IA. Opioid Use and Storage Patterns by Patients after Hospital Discharge following Surgery. PLoS One. 2016 Jan 29;11(1):e0147972. doi: 10.1371/journal.pone.0147972. eCollection 2016.

  PMID: 26824844 BACKGROUND

• Goesling J, Moser SE, Zaidi B, Hassett AL, Hilliard P, Hallstrom B, Clauw DJ, Brummett CM. Trends and predictors of opioid use after total knee and total hip arthroplasty. Pain. 2016 Jun;157(6):1259-1265. doi: 10.1097/j.pain.0000000000000516.

  PMID: 26871536 BACKGROUND

Study Officials

• Nicoleta Stoicea, MD, PhD

  Ohio State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Scientist/ Adj. Assistant Professor

Study Record Dates

• First Submitted: June 9, 2017
• First Posted: June 14, 2017
• Study Start: September 1, 2016
• Primary Completion: July 24, 2019
• Study Completion: July 24, 2019
• Last Updated: October 29, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)