Physiological Effect of Ataulfo Mango (Manguifera Indica) Beverage in Exercise

NCT03182543 | Completed DMC

• 1 other identifier: UACJ-ICB-2017-01
• Study Type: interventional
• Target: 19
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study is to assess the antioxidant capacity of two mango base beverages (AM1, AM2), against exercise-induced oxidative stress.

Conditions

Exercise-induced Oxidative Stress

Keywords

Exercise; Oxidative stress; Antioxidant

Outcome Measures

Primary Outcomes (3)

• Antioxidant capacity change

  Assessed by FRAP change. Blood samples were drawn from the antecubital vein into EDTA test tubes at rest, before beverage intake, and immediately following the exercise test. Samples were then centrifuged at 5000 rpm for 10 min at 4°C to obtain plasma, which was withdrawn and separated into eppendorf vials, maintained at -80°C until further biochemical analysis.

  0 min (before beverage intake), 9-15 min (immediately after exercise test)

• Antioxidant capacity change

  Assessed by uric acid concentration change. Blood samples were drawn from the antecubital vein into EDTA test tubes at rest, before beverage intake, and immediately following the exercise test. Samples were then centrifuged at 5000 rpm for 10 min at 4°C to obtain plasma, which was withdrawn and separated into eppendorf vials, maintained at -80°C until further biochemical analysis.

  0 min (before beverage intake), 9-15 (immediately after exercise test)

• Antioxidant capacity change

  Assessed by reduced glutathione concentration change. Blood samples were drawn from the antecubital vein into EDTA test tubes at rest, before beverage intake, and immediately following the exercise test. Samples were then centrifuged at 5000 rpm for 10 min at 4°C to obtain plasma, which was withdrawn and separated into eppendorf vials, maintained at -80°C until further biochemical analysis.

  0 min (before beverage intake), 9-15 (immediately after exercise test)

Secondary Outcomes (4)

• Oxidative stress change

  0 min (before beverage intake), 9-15 (immediately after exercise test)

• Oxidative stress change

  0 min (before beverage intake), 9-15 (immediately after exercise test)

• Lactic acid concentration change

  0 min (before performing exercise test), 3 min, 6 min, 9 min, 12 min, 15 min (during exercise test)

• Postprandial glycemic change

  0 min (before beverage intake), 30 min, 60 min, 90 min, 120 min (after beverage intake)

Study Arms (3)

AM1

EXPERIMENTAL

Mango pulp beverage

Dietary Supplement: Mango pulp beverage

AM2

EXPERIMENTAL

Mango pulp and peel beverage

Dietary Supplement: Mango pulp and peel beverage

Control

PLACEBO COMPARATOR

Control beverage

Dietary Supplement: Control beverage

Interventions

Mango pulp beverage DIETARY_SUPPLEMENT

The subject consumes mango pulp beverage (200 g mango pulp + 600 mL water). 2 hours later subject performs the exercise test. Washout: 1 week washout period prior to the administration of this intervention to avoid possible carryover effect.

Also known as: AM1, 200 g mango pulp + 600 mL water

AM1

Mango pulp and peel beverage DIETARY_SUPPLEMENT

The subject consumes mango pulp and peel beverage (160 g mango pulp + 40 g mango peel + 600 mL water). 2 hours later subject performs the exercise test. Washout: 1 week washout period prior to the administration of this intervention to avoid possible carryover effect.

Also known as: AM2, 160 g mango pulp + 40 g mango peel + 600 mL water

AM2

Control beverage DIETARY_SUPPLEMENT

The subject consumes control beverage (600 mL water). 2 hours later subject performs the exercise test. Washout: 1 week washout period prior to the administration of this intervention to avoid possible carryover effect.

Also known as: 600 mL water

Control

Eligibility Criteria

• Age: 17 Years - 28 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• healthy male
• university student
• no alcohol, cigar or drugs consumption

You may not qualify if:

• no antioxidant supplement or ergogenic consumption
• health issues with performing physical activity

Sponsors & Collaborators

• Universidad Autonoma de Ciudad Juarez: lead

Related Publications (5)

• Alvarez-Parrilla E, De La Rosa LA, Legarreta P, Saenz L, Rodrigo-Garcia J, Gonzalez-Aguilar GA. Daily consumption of apple, pear and orange juice differently affects plasma lipids and antioxidant capacity of smoking and non-smoking adults. Int J Food Sci Nutr. 2010 Jun;61(4):369-80. doi: 10.3109/09637480903514041.

  PMID: 20109132 BACKGROUND

• Ramos-Jimenez A, Hernandez-Torres RP, Wall-Medrano A, Torres-Duran PV, Juarez-Oropeza MA, Solis Ceballos JA. Acute physiological response to indoor cycling with and without hydration; case and self-control study. Nutr Hosp. 2013 Sep-Oct;28(5):1487-93. doi: 10.3305/nh.2013.28.5.6698.

  PMID: 24160205 BACKGROUND

• Spirlandeli AL, Deminice R, Jordao AA. Plasma malondialdehyde as biomarker of lipid peroxidation: effects of acute exercise. Int J Sports Med. 2014 Jan;35(1):14-8. doi: 10.1055/s-0033-1345132. Epub 2013 Jun 14.

  PMID: 23771832 BACKGROUND

• Wang CY, Haskell WL, Farrell SW, Lamonte MJ, Blair SN, Curtin LR, Hughes JP, Burt VL. Cardiorespiratory fitness levels among US adults 20-49 years of age: findings from the 1999-2004 National Health and Nutrition Examination Survey. Am J Epidemiol. 2010 Feb 15;171(4):426-35. doi: 10.1093/aje/kwp412. Epub 2010 Jan 15.

  PMID: 20080809 BACKGROUND

• Wall-Medrano A, Olivas-Aguirre FJ, Velderrain-Rodriguez GR, Gonzalez-Aguilar A, de la Rosa LA, Lopez-Diaz JA, Alvarez-Parrilla E. [Mango: agroindustrial aspects, nutritional/functional value and health effects]. Nutr Hosp. 2014 Nov 1;31(1):67-75. doi: 10.3305/nh.2015.31.1.7701. Spanish.

  PMID: 25561099 BACKGROUND

MeSH Terms

Conditions

Motor Activity

Interventions

Water

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Hydroxides; Alkalies; Inorganic Chemicals; Anions; Ions; Electrolytes; Oxides; Oxygen Compounds

Study Officials

• Abraham Wall-Medrano, PhD

  Universidad Autónoma de Ciudad Juárez

  STUDY DIRECTOR

• Gregorio Chavez-Treviño, MS

  Universidad Autónoma de Ciudad Juárez

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The prescription of the treatments (AM1, AM2) and control (water) was randomized. The subject consumed 600mL of AM1, AM2 or water. 2 hours later subject performed the exercise test. Next treatment was evaluated after a week of wash-out.

Study Record Dates

• First Submitted: May 29, 2017
• First Posted: June 9, 2017
• Study Start: January 1, 2017
• Primary Completion: February 28, 2017
• Study Completion: April 30, 2017
• Last Updated: June 9, 2017

Record last verified: 2017-06

Data Sharing

• IPD Sharing: Will not share