Provider Perceptions of Neuromuscular Blockade in ARDS

NCT03179709 | Completed

• 2 other identifiers: 170115U01HL123020
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

The proposed study will use qualitative methodology to understand health care provider perceptions of neuromuscular blockade (NMB) in patients with Acute Respiratory Distress Syndrome (ARDS). To achieve this goal the investigators will conduct a prospective ancillary study at four clinical centers participating in the NHLBI PETAL network as part of the ROSE (Reevaluation of Systemic Early Neuromuscular Blockade) clinical trial (NCT02509078). Using thematic content analysis of semistructured interviews with health care providers caring for patients enrolled in the ROSE trial the investigators will determine the barriers to NMB use and develop a framework for future NMB adoption in ARDS.

Conditions

Neuromuscular Blockade; Acute Respiratory Distress Syndrome

Keywords

Acute Respiratory Distress Syndrome; Neuromuscular Blockade; Interviews; Implementation Science

Outcome Measures

Primary Outcomes (2)

• Barriers to adoption of NMB

  As a qualitative study, this study has no quantitative outcome measures. Provider perceptions of the knowledge, attitude, and behavioral barriers to adoption of early NMB in ARDS will be assessed using a semi-structured interview guide.

  1 month post enrollment

• Contextual factors that influence the effectiveness of NMB

  As a qualitative study, this study has no quantitative outcome measures. Provider perceptions of the clinical and organizational factors that influence the impact of NMB on patient centered outcomes will be assessed using a semi-structured interview guide.

  1 month post enrollment

Study Arms (3)

Intervention

The investigators will interview physicians, nurses, respiratory therapists and other clinicians who have cared for patients enrolled in the active treatment arm of ROSE.

Behavioral: Interview

Control

The investigators will interview physicians, nurses, respiratory therapists and other clinicians who have cared for patients enrolled in the control treatment arm of ROSE.

Behavioral: Interview

Refusal

The investigators will interview physicians who have refused to allow their patients to be enrolled in ROSE.

Behavioral: Interview

Interventions

Interview BEHAVIORAL

The investigators will perform and analyze semi-structured interviews with enrolled participants.

Control; Intervention; Refusal

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Health care professionals with direct experience in either caring for patients enrolled in the ROSE trial (NCT02509078) or caring for patients with ARDS eligible for ROSe but not enrolled.

You may qualify if:

• physician, nurse, respiratory therapist or clinical pharmacist providing direct care for patients enrolled in the ROSE study; or physician who refused entry of their patient into the ROSE study

You may not qualify if:

• none

Sponsors & Collaborators

• University of Pittsburgh: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

University of Pittburgh Medical Center

Pittsburgh, Pennsylvania, 15261, United States

Location

MeSH Terms

Conditions

Respiratory Distress Syndrome

Interventions

Interviews as Topic

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Jeremy M Kahn, MD, MS

  University of Pittsburgh

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Critical Care Medicine

Study Record Dates

• First Submitted: May 31, 2017
• First Posted: June 7, 2017
• Study Start: July 1, 2017
• Primary Completion: March 18, 2018
• Study Completion: March 18, 2018
• Last Updated: January 7, 2020

Record last verified: 2020-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)