Autophagy and Pathological Aging

NCT03175874 | Completed

• 1 other identifier: 17-PP-03
• Study Type: interventional
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

Autophagy is recognized as a central mechanism for the regulation of aging. . Osteoporosis (OA) and Alzheimer's disease (AD) are two forms of pathological aging, sometimes entangled, including an over-risk of OP in AD and degradation of cognitive functions after OP fracture, but the link between These two pathologies remain poorly understood. The aim of this prospective pilot study is to evaluate the level of autophagy of osteocytes (OST) in postmenopausal women with OP and to explore the hypothesis that the defect of autophagy is one of the physiopathological links of the OP During the MA

Conditions

Osteoporosis

Keywords

Osteoporosis; Alzheimer Disease

Outcome Measures

Primary Outcomes (1)

• Quantification of autophagy

  Quantification of autophagy (LC3II and SQSTM1 / p62) by Western blotting of purified OST proteins from a bone sample from resected femoral heads

  at inclusion

Secondary Outcomes (2)

• Bone mineral density

  at inclusion

• 25 OH vitamin D (ng/ml).

  at inclusion

Study Arms (3)

osteoporosis and alzheimer

OTHER

patient with osteoporosis and alzheimer hospitalized for total hip prosthesis.

Procedure: Hip bone sampling

osteoporosis without alzheimer

OTHER

Patient with osteoporosis without alzheimer hospitalized for total hip prosthesis.

Procedure: Hip bone sampling

Patient with arthrosis without alzheimer

OTHER

Patient with arthrosis without alzheimer hospitalized for total hip prosthesis.

Procedure: Hip bone sampling

Interventions

Hip bone sampling PROCEDURE

Quantification of autophagy (LC3II and SQSTM1 / p62) by Western blotting of purified OST proteins from a bone sample

Patient with arthrosis without alzheimer; osteoporosis and alzheimer; osteoporosis without alzheimer

Eligibility Criteria

• Age: 65 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Women \> 65 y: 2 groups
• Osteoporotic femoral neck fracture requiring hip remplacement and fullfilling WHO definition of osteoporosis. Without any cognitive impairment for the first subgroup (MMSE \> 26 and normal IADL) and with a final diagnosis of alzheimer disease in the other subgroup (DSM-IV-TR)
• Non osteoporotic (no fragility fracture (clinical or on VFA) and bone mineral density T-score \> 2.5 SD at all sites)
• No cognitive impairment (MMSE \> 26 and normal IADL)

You may not qualify if:

• Other pathologies associated with autophagy: Parkinson's disease, Crohn's disease, cancers, myopathies, type 2 diabetes
• Méd Medications interfering with autophagy: current corticosteroids, parathyroid hormone, estrogen, chloroquine, hydroxychloroquine, lithium, metformin, bisphosphonates,
• Dementia of non-Alzheimer type

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

BREUIL

Nice, 06000, France

Location

Related Publications (1)

• Trojani MC, Clave A, Bereder I, Camuzard O, Bernard De Dompsure R, Gonzalez JF, Trojani C, Santucci-Darmanin S, Carle GF, Breuil V, Pierrefite-Carle V. Autophagy markers are decreased in bone of osteoporotic patients: a monocentric comparative study. Eur J Endocrinol. 2024 Mar 2;190(3):K27-K31. doi: 10.1093/ejendo/lvae017.

  PMID: 38430550 RESULT

MeSH Terms

Conditions

Osteoporosis; Alzheimer Disease

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Veronique BREUIL, PhD

  Centre Hospitalier Universitaire de Nice

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Quantification of autophagy (LC3II and SQSTM1 / p62) by Western blotting of purified OST proteins from a bone sample from resected femoral heads during laying of a total hip prosthesis.

Study Record Dates

• First Submitted: May 29, 2017
• First Posted: June 5, 2017
• Study Start: December 20, 2017
• Primary Completion: May 20, 2021
• Study Completion: May 20, 2021
• Last Updated: March 24, 2026

Record last verified: 2026-03

Locations

FR (1)