Specific Small RNA in Plasma for Predicting Diaphragm Dysfunction in Mechanically Ventilated Patients

NCT03172169 | Unknown DMC

• 1 other identifier: miRNA and Diaphragm
• Study Type: observational
• Target: 140
• Locations: 0 countries
• Sites: N/A

Brief Summary

Through the literature screening of MyomiRX 7, the detection of mechanical ventilation group, difficult withdrawal unit and healthy adult plasma levels of MyomiRX in the evaluation of function and skeletal muscle thickness of the diaphragm, the correlation analysis of 7 kinds of MyomiRX and diaphragmatic dysfunction. The research value of this project is to explore the predictive value of plasma MyomiRX level on diaphragmatic dysfunction in patients with mechanical ventilation, and to lay the foundation for finding the target of VIDD diagnosis and treatment

Conditions

Mechanical Ventilation Complication

Outcome Measures

Primary Outcomes (1)

• Prediction of diaphragmatic dysfunction using RT-PCR microRNA level

  Prediction of diaphragmatic dysfunction in patients with mechanical ventilation by specific minute RNA of plasma muscle tissue

  7 days

Study Arms (3)

Healthy control group

no intervention

Other: no Intervention

Difficult withdrawal group

The mechanical ventilation time was \>48 hours and the first SBT failure

Other: no Intervention

Mechanical ventilation control group

Elective and expected postoperative control of mechanical ventilation time greater than 12h after cardiothoracic surgery

Other: no Intervention

Interventions

no Intervention OTHER

no Intervention

Difficult withdrawal group; Healthy control group; Mechanical ventilation control group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

healthy control group: healthy volunteers mechanical ventilation control group: patients who underwent elective cardiothoracic surgery after scheduled and controlled mechanical ventilation for more than 12h were transferred to ICU (including coronary artery bypass grafting and valve replacement) difficult weaning: difficult to diagnose patients in ICU (weaning time from mechanical ventilation for \>48 hours and first SBT failure)

You may qualify if:

• healthy control group: healthy volunteers mechanical ventilation control group: patients who underwent elective cardiothoracic surgery after scheduled and controlled mechanical ventilation for more than 12h were transferred to ICU (including coronary artery bypass grafting and valve replacement) difficult weaning: difficult to diagnose patients in ICU (weaning time from mechanical ventilation for \>48 hours and first SBT failure)

You may not qualify if:

• severe respiratory depression, high paraplegia and neuromuscular lesions;
• esophageal obstruction, esophageal perforation, severe esophageal varices bleeding, upper gastrointestinal surgery and other reasons can not be placed EAdi catheter;
• thoracic deformity and diaphragmatic hernia;
• serious heart, liver, kidney and other organ failure, hemodynamic instability;
• pregnancy;
• the end of the tumor or the family member give up the active treatment

Sponsors & Collaborators

• Southeast University, China: lead

Study Officials

• pan chun, doctor

  Colleague

  PRINCIPAL INVESTIGATOR

Central Study Contacts

xu xiaoting, master

CONTACT

+86 13645188041; xuxiaoting2005@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 29, 2017
• First Posted: June 1, 2017
• Study Start: June 15, 2017
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: June 6, 2017

Record last verified: 2017-06