Trials Sponsors Conditions Drugs Pricing

Conditions

Squamous Cell Carcinoma of the Head and Neck

Keywords

PET/MRSquamous cell carcinomaHeterogeneity

Outcome Measures

Primary Outcomes (3)

Quantified measures from FDG PET and pathology
Correlation between FDG uptake (measured as SUV) and expression of IHC biomarkers
3-6 months
Quantified measures from DWI and pathology
Correlation between diffusion weighted imaging and expression of IHC biomarkers
3-6 months
Quantified measures from DCE and pathology
Correlation between dynamic contrast enhancement and expression of IHC biomarkers
3-6 months

Interventions

All patientsOther

All patients are scanned with PET/MR prior to surgery.

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years+

Sexall

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Please see detailed description

You may qualify if:

Informed consent
Age above 18

Sponsors & Collaborators

Copenhagen University Hospital, Rigshospitalet
Otherlead

Study Sites (1)

Department of Otorhinolaryngology, Head & Neck Surgery and Audiology Rigshospitalet, University of Copenhagen

Copenhagen, 2100, Denmark

Biospecimen

Retention: SAMPLES WITH DNA

The gross specimen will be examined, sectioned and placed in tissue cassettes as done in routine. Six tissue blocks will be picked for microscopic evaluation and IHC staining. The specific selection of cancer related IHC biomarkers is based on their relationship with tumor cell metabolism, radiotherapy resistance (proliferation and hypoxia), association with FDG accumulation and institutional experience from a previous study

MeSH Terms

Conditions

Squamous Cell Carcinoma of Head and NeckCarcinoma, Squamous Cell

Condition Hierarchy (Ancestors)

CarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasmsHead and Neck NeoplasmsNeoplasms by SiteNeoplasms, Squamous Cell

Enrollment

33 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: OTHER
Time Perspective: PROSPECTIVE
Target Duration: 1 Day
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: MD, PhD

Study Record Dates

First Submitted

May 16, 2017

First Posted

May 19, 2017

Study Start

March 29, 2017

Actual (reported)

Functional ImaGing of Heterogeneity in Head and Neck Tumors - Validation From Surgical Specimens

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (3)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (3)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations