Key Insights

Highlights

Success Rate

69% trial completion

Published Results

55 trials with published results (31%)

Research Maturity

92 completed trials (51% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 74/100

Termination Rate

22.8%

41 terminated out of 180 trials

Success Rate

69.2%

-17.4% vs benchmark

Late-Stage Pipeline

9%

16 trials in Phase 3/4

Results Transparency

60%

55 of 92 completed with results

Key Signals

55 with results69% success41 terminated

Data Visualizations

Phase Distribution

159Total
Not Applicable (14)
Early P 1 (2)
P 1 (69)
P 2 (58)
P 3 (15)
P 4 (1)

Trial Status

Completed92
Terminated41
Unknown15
Recruiting11
Active Not Recruiting10
Not Yet Recruiting5

Trial Success Rate

69.2%

Benchmark: 86.6%

Based on 92 completed trials

Clinical Trials (180)

Showing 20 of 20 trials
NCT07847060Not ApplicableNot Yet Recruiting

Hypofractionated Radiotherapy in Older Adults With Head and Neck Squamous Cell Carcinoma

NCT06736379Phase 1Recruiting

Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

NCT04191460Phase 2CompletedPrimary

Fluorescence-guided Surgery Using cRGD-ZW800-1 in Oral Cancer

NCT05059444Recruiting

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

NCT04590963Phase 3Active Not RecruitingPrimary

Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer

NCT05751512Phase 3RecruitingPrimary

A Study to Evaluate MRG003 vs Cetuximab/Methotrexate in in the Treatment of Patients With RM-SCCHN

NCT06223568Phase 2Active Not RecruitingPrimary

Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer

NCT02296684Phase 2Completed

Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma

NCT04290546Phase 1CompletedPrimary

CIML NK Cell in Head & Neck Cancer

NCT05208762Phase 1Recruiting

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

NCT03690986Phase 1Active Not RecruitingPrimary

VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Head and Neck Cancer

NCT03712566Active Not Recruiting

Multi-Omic Assessment of Squamous Cell Cancers Receiving Systemic Therapy

NCT04609566Phase 2Completed

Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors

NCT03139058Not ApplicableTerminated

Prevalence of Liver Fibrosis and Cirrhosis in Patients With Squamous Cell Carcinoma of the Head and Neck

NCT04881045Phase 1Completed

Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors.

NCT05783622Phase 1Active Not Recruiting

Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

NCT03646461Phase 2Terminated

Trial of Ibrutinib Combined With Nivolumab or Cetuximab to Treat Recurrent/Metastatic HNSCC

NCT03645928Phase 2Terminated

Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors

NCT02841748Phase 2Completed

A Randomized, Double-Blind Phase II Study of Adjuvant Pembrolizumab Versus Placebo in Head and Neck Cancers at High Risk for Recurrence- the PATHWay Study

NCT05983133Phase 1Terminated

A Study of PF-08046052/SGN-EGFRd2 in Advanced Solid Tumors

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