Prevalence of Early Childhood Caries in Egyptian Children With Serum Vitamin D Deficiency.

NCT03158155 | Unknown DMC

• 1 other identifier: CEBD-2017-5-101
• Study Type: observational
• Target: 288
• Locations: 0 countries
• Sites: N/A

Brief Summary

To detect the effect of vitamin D deficiency in the development of early childhood caries (ECC) among Egyptian children.

Conditions

Vitamin D Deficiency

Outcome Measures

Primary Outcomes (1)

• Prevalence of early childhood caries

  Stages of Early childhood caries. 1. Initial (reversible stage) 2. Damaged (carious) stage 3. Deep lesions 4. Traumatic stage. 5. Arrested caries.

  6 months

Secondary Outcomes (2)

• Delayed tooth formation and eruption

  6 months

• Gingivitis

  6 months

Study Arms (1)

Patients with vitamin D deficiency

1\. children with vitamin D deficiency with age group from 2-5 years old

Eligibility Criteria

• Age: 2 Years - 5 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Egyptain children age ranges from 2 to 5 years from Abo El Rish Hospital, Malnutrition clinic.

You may qualify if:

• Children ages from two to five years
• Both sexes.
• Parent and children cooperation.
• Healthy children.
• Children with serum vitamin D deficiency.

You may not qualify if:

• Children age more than 5 years.
• Children had a complex metabolic or medical disorder.
• Parents that will not sign the consent.

Sponsors & Collaborators

• Nancy Ahmed El Salmawy: lead

Related Publications (21)

• Policy on Early Childhood Caries (ECC): Classifications, Consequences, and Preventive Strategies. Pediatr Dent. 2016 Oct;38(6):52-54. No abstract available.

  PMID: 27931420 BACKGROUND

• Anthonappa, R. P., and King, N. M. (2015). Enamel defects in the permanent dentition: prevalence and etiology. Springer-Verlag Berlin Heidelberg 2015; B.K. Drummond, N. Kilpatrick (eds.), Planning and Care for Children and Adolescents with Dental Enamel Defects: Etiology, Research and Contemporary Management, pp. 15-30

  BACKGROUND

• Antonenko O, Bryk G, Brito G, Pellegrini G, Zeni SN. Oral health in young women having a low calcium and vitamin D nutritional status. Clin Oral Investig. 2015 Jul;19(6):1199-206. doi: 10.1007/s00784-014-1343-x. Epub 2014 Oct 31.

  PMID: 25359326 BACKGROUND

• Baumann, F., Jäger, E., & Bloch, W. (2013).Vitamin D -office of dietary supplements-National instituted health. Journal of Molecular Modeling

  BACKGROUND

• Bener, A., Al Darwish, M. S., and Hoffmann , G. F. (2013). Vitamin D deficiency and risk of dental caries among young children: A public health problem. Indian Journal of Oral Sciences, 4(2): 75-82

  BACKGROUND

• Bener A, Alsaied A, Al-Ali M, Al-Kubaisi A, Basha B, Abraham A, Guiter G, Mian M. High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children. Acta Diabetol. 2009 Sep;46(3):183-9. doi: 10.1007/s00592-008-0071-6. Epub 2008 Oct 10.

  PMID: 18846317 BACKGROUND

• Wagner CL, Greer FR; American Academy of Pediatrics Section on Breastfeeding; American Academy of Pediatrics Committee on Nutrition. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008 Nov;122(5):1142-52. doi: 10.1542/peds.2008-1862.

  PMID: 18977996 BACKGROUND

• Douglass JM, Douglass AB, Silk HJ. A practical guide to infant oral health. Am Fam Physician. 2004 Dec 1;70(11):2113-20.

  PMID: 15606059 BACKGROUND

• Dudding T, Thomas SJ, Duncan K, Lawlor DA, Timpson NJ. Re-Examining the Association between Vitamin D and Childhood Caries. PLoS One. 2015 Dec 21;10(12):e0143769. doi: 10.1371/journal.pone.0143769. eCollection 2015.

  PMID: 26692013 BACKGROUND

• East BR. Mean Annual Hours of Sunshine and the Incidence of Dental Caries. Am J Public Health Nations Health. 1939 Jul;29(7):777-80. doi: 10.2105/ajph.29.7.777. No abstract available.

  PMID: 18015076 BACKGROUND

• Fuleihan Gel-H, Bouillon R, Clarke B, Chakhtoura M, Cooper C, McClung M, Singh RJ. Serum 25-Hydroxyvitamin D Levels: Variability, Knowledge Gaps, and the Concept of a Desirable Range. J Bone Miner Res. 2015 Jul;30(7):1119-33. doi: 10.1002/jbmr.2536. Epub 2015 May 7.

  PMID: 25952470 BACKGROUND

• Grant WB. A review of the role of solar ultraviolet-B irradiance and vitamin D in reducing risk of dental caries. Dermatoendocrinol. 2011 Jul;3(3):193-8. doi: 10.4161/derm.3.3.15841. Epub 2011 Jul 1.

  PMID: 22110779 BACKGROUND

• Guay AH. Access to dental care: solving the problem for underserved populations. J Am Dent Assoc. 2004 Nov;135(11):1599-605; quiz 1623. doi: 10.14219/jada.archive.2004.0088.

  PMID: 15622666 BACKGROUND

• Herzog K, Scott JM, Hujoel P, Seminario AL. Association of vitamin D and dental caries in children: Findings from the National Health and Nutrition Examination Survey, 2005-2006. J Am Dent Assoc. 2016 Jun;147(6):413-20. doi: 10.1016/j.adaj.2015.12.013. Epub 2016 Jan 27.

  PMID: 26827077 BACKGROUND

• Krall EA, Wehler C, Garcia RI, Harris SS, Dawson-Hughes B. Calcium and vitamin D supplements reduce tooth loss in the elderly. Am J Med. 2001 Oct 15;111(6):452-6. doi: 10.1016/s0002-9343(01)00899-3.

  PMID: 11690570 BACKGROUND

• Mellanby M, Pattison CL. THE ACTION OF VITAMIN D IN PREVENTING THE SPREAD AND PROMOTING THE ARREST OF CARIES IN CHILDREN. Br Med J. 1928 Dec 15;2(3545):1079-82. doi: 10.1136/bmj.2.3545.1079. No abstract available.

  PMID: 20774325 BACKGROUND

• Najeeb S, Zafar MS, Khurshid Z, Zohaib S, Almas K. The Role of Nutrition in Periodontal Health: An Update. Nutrients. 2016 Aug 30;8(9):530. doi: 10.3390/nu8090530.

  PMID: 27589794 BACKGROUND

• Youssef DA, Miller CW, El-Abbassi AM, Cutchins DC, Cutchins C, Grant WB, Peiris AN. Antimicrobial implications of vitamin D. Dermatoendocrinol. 2011 Oct;3(4):220-9. doi: 10.4161/derm.3.4.15027. Epub 2011 Oct 1.

  PMID: 22259647 BACKGROUND

• Potturu, M., Prabhakaran, P. A., Oommen, N., Sarojini, D. M., and Sunil, S. N.(2014). Cathelicidin expression and role in oral health and diseases: A short review. Tropical J. of Med. Res., 17 (2): 69-75.

  BACKGROUND

• Schroth RJ, Lavelle C, Tate R, Bruce S, Billings RJ, Moffatt ME. Prenatal vitamin D and dental caries in infants. Pediatrics. 2014 May;133(5):e1277-84. doi: 10.1542/peds.2013-2215.

  PMID: 24753535 BACKGROUND

• American Academy of Pediatric Dentistry Clinical Affairs Committee; American Academy of Pediatric Dentistry Council on Clinical Affairs. Guideline on periodicity of examination, preventive dental services, anticipatory guidance, and oral treatment for children. Pediatr Dent. 2005-2006;27(7 Suppl):84-6. No abstract available.

  PMID: 16541901 RESULT

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood samples will be obtained from children recruited in the study at the day of diagnosis, seven mm of blood will collect approximately, using radioimmunoassay technique for measuring vitamin D serum level All serum analysis will be done in Radioisotope Department, Nuclear Research Center, and Atomic Energy Authority.

MeSH Terms

Conditions

Vitamin D Deficiency

Condition Hierarchy (Ancestors)

Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases

Study Officials

• Nourhan A. El dokky, A. Professor

  neldokky@hotmail.com

  STUDY DIRECTOR

Central Study Contacts

Nancy A El salmawy, Master

CONTACT

+201001891010; nancyyy_911@hotmain.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator,

Study Record Dates

• First Submitted: May 16, 2017
• First Posted: May 18, 2017
• Study Start: July 15, 2017
• Primary Completion: July 15, 2018
• Study Completion: July 18, 2018
• Last Updated: June 7, 2017

Record last verified: 2017-06