Alcohol Intake, Alcohol Metabolizing Enzymes Gene Polymorphisms and the Risk of Colorectal Cancer

NCT03155542 | Completed

• 1 other identifier: 201610059RIND
• Study Type: observational
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

According to the statistic reports from World Health Organization (WHO) International Agency for Research on Cancer (IARC), the incidence and mortality rate of colorectal cancer ranked third and fourth respectively among ten most commonly diagnosed cancer worldwide; moreover, based on the statistics from Health Promotion Administration, Ministry of Health and Welfare in Taiwan, the incidence and mortality rate of colorectal cancer ranked second and third respectively among call cancer in Taiwanese population. However, if colorectal cancer is diagnosed and treated in early phase, the 5-year survival rate for stage I colorectal cancer can be up to 90%; on the other hand, the 5-year survival rate for end stage colorectal cancer is only approximately 10%. Therefore, the screening, early diagnosis od colorectal cancer is crucial. To date, there are some known risk factors for colorectal cancer, including familial adenomatous polyposis, obesity, physical inactivity, etc. Alcohol had also been identified as an important risk factor for colorectal cancer, and the risk could be higher among Asian population because of the reduced enzymatic activity of some of the alcohol metabolizing enzymes. Thus, through this study, the investigators hope to find out the risk factors of colorectal cancer among Taiwanese population, including alcohol metabolizing enzyme gene polymorphisms and their interaction with environmental factors, to attain the purpose of early prevention of colorectal cancer.

Conditions

Colorectal Neoplasms

Keywords

alcohol; gene polymorphisms; Colorectal cancer

Outcome Measures

Primary Outcomes (1)

• colorectal cancer diagnosis

  Histologically confirmed colorectal adenocarcinoma

  4 months

Study Arms (2)

colorectal cancer patient case group

Histologically confirmed colorectal adenocarcinoma

family member control group

without the diagnosis of CRC and accompanied the patient to the primary care clinic visit

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

primary care clinic visit at National Taiwan University Hospital

You may qualify if:

• Case:
• Histologically confirmed colorectal adenocarcinoma at National Taiwan University Hospital (NTUH) from 2000 to 2016
• Control:
• No diagnosis of colorectal cancer
• Family members of case, including parents, siblings, offspring, spouse mother-in-law or daughter-in-law

You may not qualify if:

• History of familial adenomatous polyposis
• History of partial or total removal of the colorectum
• History of inflammatory bowl disease
• History of malignant neoplasms

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, ROC, Taiwan

Location

Biospecimen

Retention: SAMPLES WITH DNA

5-10 ml venous blood sample

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Study Officials

• Yen-Hui CHEN

  Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 14, 2017
• First Posted: May 16, 2017
• Study Start: December 1, 2016
• Primary Completion: March 22, 2017
• Study Completion: March 29, 2017
• Last Updated: May 23, 2017

Record last verified: 2017-05

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)