Non-Invasive Aortic Ambulatory Blood Pressure Monitoring for The Detection of Target Organ Damage in The Chinese Population

NCT03154203 | Unknown

• 1 other identifier: SAFAR-CN
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a sub-investigation of SAFAR study. Consecutive patients with established hypertension (treated or untreated with antihypertensive drugs) or with suspected hypertension are recruited and their 24-hour brachial and aortic blood pressures, cardiovascular risk factors and target organ damage are assessed. And the participants' target organ damage, cardiovascular events, cardiovascular and overall mortality will be followed four years later.

Conditions

Blood Pressure; Cardiovascular Risk Factor; Target Organ Damage; Cardiovascular Events; Cardiovascular Mortality; Overall Mortality

Outcome Measures

Primary Outcomes (2)

• Cardiovascular events

  4 years

• cardiovascular and all-cause mortality

  4 years

Interventions

No intervention in this study OTHER

No intervention in this study

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Consecutive patients with established hypertension (treated or untreated with antihypertensive drugs) or with suspected hypertension

You may qualify if:

• patients with established hypertension (treated or untreated with antihypertensive drugs) or with suspected hypertension

You may not qualify if:

• Age\<18 years old
• the absence of sinus rhythm during BP monitoring
• any modification in cardiovascular disease medication in the past month
• inability to provide informed consent or unwillingness/inability to adhere to study protocol

Sponsors & Collaborators

• Shanghai 10th People's Hospital: lead

Study Sites (1)

Shanghai Tenth People's Hospital

Shanghai, Shanghai Municipality, 200072, China

RECRUITING

Related Publications (3)

• Aissopou EK, Argyris AA, Nasothimiou EG, Konstantonis GD, Tampakis K, Tentolouris N, Papathanassiou M, Theodossiadis PG, Papaioannou TG, Stehouwer CD, Sfikakis PP, Protogerou AD. Ambulatory Aortic Stiffness Is Associated With Narrow Retinal Arteriolar Caliber in Hypertensives: The SAFAR Study. Am J Hypertens. 2016 May;29(5):626-33. doi: 10.1093/ajh/hpv145. Epub 2015 Aug 24.

  PMID: 26304958 RESULT

• Zhang Y, Kollias G, Argyris AA, Papaioannou TG, Tountas C, Konstantonis GD, Achimastos A, Blacher J, Safar ME, Sfikakis PP, Protogerou AD. Association of left ventricular diastolic dysfunction with 24-h aortic ambulatory blood pressure: the SAFAR study. J Hum Hypertens. 2015 Jul;29(7):442-8. doi: 10.1038/jhh.2014.101. Epub 2014 Nov 13.

  PMID: 25391758 RESULT

• Protogerou AD, Argyris AA, Papaioannou TG, Kollias GE, Konstantonis GD, Nasothimiou E, Achimastos A, Blacher J, Safar ME, Sfikakis PP. Left-ventricular hypertrophy is associated better with 24-h aortic pressure than 24-h brachial pressure in hypertensive patients: the SAFAR study. J Hypertens. 2014 Sep;32(9):1805-14. doi: 10.1097/HJH.0000000000000263.

  PMID: 24999798 RESULT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Department of Cardiology, Professor of Tongji University, FACC

Study Record Dates

• First Submitted: May 7, 2017
• First Posted: May 16, 2017
• Study Start: June 1, 2017
• Primary Completion: June 30, 2018
• Study Completion: June 30, 2021
• Last Updated: August 21, 2017

Record last verified: 2017-08

Locations

CN (1)