Hypermetabolism in the Elderly Lung Cancer Patient
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1 other identifier
observational
27
1 country
1
Brief Summary
Aging and cancer are two conditions associated with extensive metabolic changes that can cause malnutrition. However, the clinical features and the underlying mechanisms leading to malnutrition are different in these two cases. We therefore wonder how age can influence the metabolic response to cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jan 2016
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2016
CompletedFirst Submitted
Initial submission to the registry
April 28, 2017
CompletedFirst Posted
Study publicly available on registry
May 5, 2017
CompletedMay 8, 2017
May 1, 2017
10 months
April 28, 2017
May 4, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Measured resting energy expenditure (mREE) in kilocalorie per day
Energy expenditure is measured by indirect calorimetry.
Day 0
Secondary Outcomes (14)
Blood C-Reactive Protein in milligram per milliliter
Day 0
Blood Interleukine-6 in picogram per milliliter
Day 0
Blood Tumor Necrosis Factor alpha in picogram per milliliter
Day 0
Blood Insulin in milliunit per liter
Day 0
Blood ultra-sensitive Thyroid Stimulating Hormone in milliunit per liter
Day 0
- +9 more secondary outcomes
Study Arms (2)
Young patients
Patients with non-small cell lung carcinoma younger than 75y
Elderly patients
Patients with non-small cell lung carcinoma aged 75 or more
Eligibility Criteria
The population is selected from the patients coming for their one-day pre-treatment evaluation at the oncology ward of the Cochin Hospital.
You may qualify if:
- Non-small cell lung carcinoma
You may not qualify if:
- Imbalanced Diabetes
- Imbalanced dysthyroidia
- Any chronic auto-immune or inflammatory disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hopital Cochin
Paris, 75014, France
Related Publications (1)
Ulmann G, Jouinot A, Tlemsani C, Curis E, Kousignian I, Neveux N, Durand JP, Goldwasser F, Cynober L, De Bandt JP. Lean Body Mass and Endocrine Status But Not Age Are Determinants of Resting Energy Expenditure in Patients with Non-Small Cell Lung Cancer. Ann Nutr Metab. 2019;75(4):223-230. doi: 10.1159/000504874. Epub 2019 Dec 19.
PMID: 31865308DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Doctor
Study Record Dates
First Submitted
April 28, 2017
First Posted
May 5, 2017
Study Start
January 1, 2016
Primary Completion
November 1, 2016
Study Completion
November 1, 2016
Last Updated
May 8, 2017
Record last verified: 2017-05
Data Sharing
- IPD Sharing
- Will not share