Follow-up of a Cohort of Patients With Aortic Valve Bicuspidia

NCT03139786 | Recruiting

• 1 other identifier: PI2012_843_0014
• Study Type: observational
• Target: 232
• Locations: 1 country
• Sites: 1

Brief Summary

The aortic valve bicuspidia (BVA) is a congenital condition corresponding to the presence of 2 sigmoids instead of 3. This is the most common cardiac congenital anomaly affecting 0.5 to 2% of the population The general rule. BVA may be associated with structural damage to the ascending aorta, which exposes BVA patients to a risk of developing ascending aortic aneurysm and acute aortic accidents. Recent data from the literature have revealed that the natural history of BVA is marked by a possible development towards significant valvulopathy and / or an ascending aortic aneurysm often requiring surgical treatment. However, the natural history of bicuspid disease remains poorly understood and the prognostic factors for progression to severe valvulopathy and / or aneurysmal dilatation of the ascending aorta remain to be determined.

Conditions

Aortic Valve, Bicuspid

Outcome Measures

Primary Outcomes (1)

• Analysis of 10 year mortality in cardiac surgery in a patient with bicuspid

  Analyzing the natural history of Bicuspidia

  10 years

Interventions

Study the natural history of bicuspid OTHER

Study the natural history of bicuspid

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with aortic bicuspidia examined in the echocardiography laboratory at one of the participating centers will be systematically eligible to participate in the study

You may qualify if:

• All patients examined in the echocardiography laboratory whose objective examination was a bicuspid valve of the aortic valve
• Bicuspidia may be formerly known

You may not qualify if:

• Refusal to participate
• Patients who had already undergone bicuspid surgery or ascending aorta before being examined at the echocardiography laboratory

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens Picardie

Amiens, Picardie, 80054, France

RECRUITING

MeSH Terms

Conditions

Bicuspid Aortic Valve Disease

Condition Hierarchy (Ancestors)

Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Aortic Valve Disease; Heart Valve Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Central Study Contacts

Christophe TRIBOUILLOY, PhD

CONTACT

+33322455885; tribouilloy.christophe@chu-amiens.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 10, 2017
• First Posted: May 4, 2017
• Study Start: September 16, 2010
• Primary Completion (Estimated): April 1, 2035
• Study Completion (Estimated): April 1, 2035
• Last Updated: June 15, 2026

Record last verified: 2026-06

Locations

FR (1)