Self-motion Perception in Parkinson's Disease

NCT03137238 | Unknown

• 1 other identifier: SHEBA-16-3707-SDIK-CTIL
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 2

Brief Summary

Parkinson's Disease as well as being a disorder of motor function also causes a wide range of non-motor disturbances many of which are involved in the prodromal stage prior to the onset of motor symptoms. Abnormal perception in the visual and in other domains is increasingly being recognized. Control of the movement of our bodies in space involves perception of self-motion which is dependent on the processing and integration of multimodality information from the kinesthetic, proprioceptive, visual (mostly optic flow) and vestibular systems. Dysfunction in this process may contribute to disturbed postural control and thus result in gait abnormalities and falls which are common as Parkinson's disease progresses, is difficult to treat and causes disability and a loss of independence. The integration of information from different modalities ("multisensory integration") is vital for intact perception of the world. Theoretical studies, based on Bayesian statistics, have provided a framework to study multisensory-integration with predictions for an 'optimal' strategy. Many human and animal studies have demonstrated near optimal cue-integration. Yet, while multisensory integration is an active topic of research in normal brain function, with well-established tools, it has not been studied in PD. The investigators hypothesize, based on the apparent over-dependence in PD on visual cues that PD patients will demonstrate defective multisensory integration. This can have profound effects on basic motor functions. Furthermore, based on both visual and vestibular abnormalities (described above) the basic (uni-sensory) performance may also be degraded in PD. In this study the investigators will observe the basic (uni-sensory) and the multisensory integration of visual and vestibular perception of self-motion within the same experiment.

Conditions

Parkinson Disease

Keywords

Self-motion perception; Optic flow; Vestibular system; Multisensory integration; Parkinson's disease

Outcome Measures

Primary Outcomes (1)

• Change in multisensory integration

  Psychometric plot will be defined as the proportion of rightward choices as a function of heading angle and calculated by fitting the data with a cumulative Gaussian distribution function. Separate psychometric functions will construct for visual, vestibular, and combined cues. The psychophysical threshold and point of subjective equality will be the SD (σ) and mean (μ), respectively, deduced from the fitted distribution function. We will compare the actual weights patients gave to each cue to the predicted one, and thus will be able to study if their integration was optimal, compere to healthy participants. No change is expected to occur for control group. For the PD group, there may be an effect of antiparkinsonian medications, hence PD participants will be tested once after taking the regular antiparkinsonian medications and once after a 12 hour period of not taking any antiparkinsonian medication.

  All participants will come for two visits, each visit will take 1.5 - 2 hours 4 days and two weeks apart. Measurements will be taken in a continuous fashion during these visits only.

Study Arms (4)

Early_PD

People with Parkinson's disease in the early stages with low doses of antiparkinsonian medication and no motor fluctuations.

Other: Investigation of self-perception in Parkinson's disease

Advanced_PD

People with advanced Parkinson's disease with motor fluctuations.

Other: Investigation of self-perception in Parkinson's disease

Early_controls

Healthy participants matched for age and gender to the 'Early\_PD' group.

Other: Investigation of self-perception in Parkinson's disease

Advanced_controls

Healthy participants matched for age and gender to the 'Advanced\_PD' group.

Other: Investigation of self-perception in Parkinson's disease

Interventions

Investigation of self-perception in Parkinson's disease OTHER

There is no therapeutic intervention.

Advanced_PD; Advanced_controls; Early_PD; Early_controls

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

PD patients and healthy subjects.

You may qualify if:

• Both groups will be screened using the Montreal Cognitive Assessment (MoCA) test, and only individuals with normal cognitive function will be included in the study (above 22)

You may not qualify if:

• PD patients determined clinically to be at high risk of falling, indicated by scores of 3 or more on items 2.12, 2.13, 3.10, 3.11 and 3.12 of the Movement Disorder Society- Unified Parkinson's Disease Rating Scale (MDS- UPDRS).
• Participants under 18 years old
• Participants with vertigo or other active vestibular disease

Sponsors & Collaborators

• Sheba Medical Center: lead
• Bar-Ilan University, Israel: collaborator

Study Sites (2)

Sheba Medical Center

Ramat Gan, 52621, Israel

RECRUITING

Bar Ilan University

Ramat Gan, 5290002, Israel

RECRUITING

Related Publications (27)

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MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Simon Israeli-Korn, Dr

  Institute of Movement Disorders, Sheba medical center, Tel-Hashomer

  PRINCIPAL INVESTIGATOR

• Adam Zaidel, PhD

  Gonda Multidisciplinary Brain Research Center at Bar-Ilan University, Ramat-Gan

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Simon Israeli-Korn, Dr

CONTACT

+972545262014; Simon.Israeli-korn@sheba.health.gov.il

Adam Zaidel, Ph.D

CONTACT

+972558876884; ajzaidel@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 18, 2017
• First Posted: May 2, 2017
• Study Start: May 1, 2017
• Primary Completion: December 1, 2021
• Study Completion: June 1, 2022
• Last Updated: March 17, 2021

Record last verified: 2020-03

Data Sharing

• IPD Sharing: Will not share

Locations

IL (2)