Retrospective Analysis of Lymphomas and Cancers Synchronous Occurrence in Picardy From 2007 to 2012

NCT03135743 | Withdrawn

• 1 other identifier: PI2016_843_0024
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

Cancer is the leading cause of death in man and the second leading cause in women with 85,000 and 63,000 deaths, respectively, in 2012. A working group led by Holly L. Howe, PhD, in 2002 defined primary neoplasia Such as the occurrence and diagnosis of two or more independent neoplasms of different histology in the same patient. The occurrence of a new cancer has become more frequent in recent years: the prevalence of multiple primary neoplasia (NPM) is estimated between 0.73% and 11.7%. According to the French data, the risk of second cancer in people who have already had a first cancer is increased by 36% compared to the general population. Several studies have reported an increase in the risk of cancer after treatment of lymphoma but there are currently no studies on the occurrence of lymphoma and cancer of synchronous occurrence. In our department, 19 patients presented cancer and lymphoma synchronously, that is to say 6 months between 2007 and 2012. The main objective is to show that there is an increase in the incidence of cancers in patients diagnosed for lymphoma synchronously. Secondary objectives are to describe the clinical and biological characteristics of the patients concerned and to formulate hypotheses on the physiopathological mechanisms involved: peri-tumoral B-cell lymphoproliferation, alteration of the immune system or rearrangement of the BCR. In a second step, the investigator could propose a multicenter epidemiological study using data from the different Cancer Registries. If results are confirmed in a larger cohort, recommendations could be made.

Conditions

Lymphoma; Cancer

Outcome Measures

Primary Outcomes (1)

• Analysis of the occurrence of cancer and lymphoma within 6 months between 2007 and 2012

  5 years

Interventions

Show an increase in incidence of cancers in patients with synchronous lymphoma OTHER

Show an increase in incidence of cancers in patients with synchronous lymphoma

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Retrospective study on data and elements of the human body (anatomo-pathological blade) over a period of 6 years in patients with synchronous lymphoma

You may qualify if:

• Being older than 18
• Have been diagnosed for Hodgkin's or non-Hodgkin's lymphoma from 1 January 2007 to 31 December 2012
• Diagnostic confirmation either in anatomopathology or in cytology
• Delay of 6 months maximum between the two neoplasms (Synchronic / metachronous distinction)

You may not qualify if:

• Hemopathy other than lymphoma (CLL and lymphocytic lymphoma excluded)
• Cutaneous squamous cell carcinomas were not considered secondary cancer because of the absence of available incidence data (FRANCIM network)

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

MeSH Terms

Conditions

Lymphoma; Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Histologic Type; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 27, 2017
• First Posted: May 1, 2017
• Study Start: August 20, 2017
• Primary Completion: June 20, 2019
• Study Completion: June 20, 2019
• Last Updated: January 16, 2026

Record last verified: 2026-01