Hybrid Exercise Training for Weight Loss

NCT03134781 | Completed

• 1 other identifier: DoIT-UTH
• Study Type: interventional
• Target: 49
• Locations: 1 country
• Sites: 1

Brief Summary

In this study the investigators utilized a novel hybrid HIIT (high intensity interval training) exercise training approach, the Hybrid Interval Training (DoIT) workout that combines interval training, resistance exercise training and functional training in order to test the hypothesis that DoIT will be able to: i) reduce body mass, ii) improve body composition and iii) alter energy balance, of previously inactive, overweight/obese women.

Conditions

Circuit-based High Intensity Interval Training; Body Composition; Resting Metabolic Rate; Habitual Physical Activity; Performance

Outcome Measures

Primary Outcomes (10)

• Change in body mass

  At baseline, at 20 weeks and at 40 weeks.

• Change in body mass index

  At baseline, at 20 weeks and at 40 weeks.

• Change in waist circumference

  At baseline, at 20 weeks and at 40 weeks.

• Change in hip circumference

  At baseline, at 20 weeks and at 40 weeks.

• Change in waist-to-hip ratio

  At baseline, at 20 weeks and at 40 weeks.

• Change in body fat.

  Body fat assessed by whole-body dual-energy X-ray absorptiometry (DXA).

  At baseline, at 20 weeks and at 40 weeks.

• Change in fat mass

  Fat mass assessed by whole-body dual-energy X-ray absorptiometry (DXA).

  At baseline, at 20 weeks and at 40 weeks.

• Change in fat-free mass

  Fat-free mass assessed by whole-body dual-energy X-ray absorptiometry (DXA).

  At baseline, at 20 weeks and at 40 weeks.

• Change in resting metabolic rate

  Measured using a portable open-circuit indirect calorimeter with a ventilated hood system.

  At baseline, at 20 weeks and at 40 weeks.

• Change in exercise-induced caloric expenditure.

  Measured using a portable indirect calorimetry system

  At baseline, at 20 weeks and at 40 weeks.

Secondary Outcomes (5)

• Change in maximal strength (1RM)

  At baseline, at 20 weeks and at 40 weeks.

• Change in maximal oxygen consumption (VO2max)

  At baseline, at 20 weeks and at 40 weeks.

• Change in blood lactate concentration

  Pre-exercise, during the exercise and post-exercise at baseline, at 20 weeks and at 40 weeks.

• Change in habitual physical activity

  At baseline, at 20 weeks and at 40 weeks.

• Change in dietary intake

  At baseline, at 20 weeks and at 40 weeks.

Study Arms (3)

Control

EXPERIMENTAL

Participated only in measurements at baseline, at 20 weeks and at 40 weeks.

Behavioral: Control - No training

Training

EXPERIMENTAL

Participated in a supervised 40-week DoIT workout exercise training program and in measurements at baseline, at 20 weeks and at 40 weeks.

Behavioral: DoIT workout

Training-Detraining

EXPERIMENTAL

Participated in a supervised 20-week DoIT workout exercise training program and then entered a 20-week detraining period. They also participated in measurements at baseline, at 20 weeks and at 40 weeks.

Behavioral: DoIT workout - Detraining

Interventions

DoIT workout BEHAVIORAL

A hybrid small-group (5-10 women/session) training modality, that combines interval training, resistance exercise and functional training and performed according to a periodized model of exercise prescription as an alternative approach for weight management. FFIT was performed 3 times/week with 48 hours recovery between sessions for 40 weeks.

Training

DoIT workout - Detraining BEHAVIORAL

A hybrid small-group (5-10 women/session) training modality, that combines interval training, resistance exercise and functional training, performed according to a periodized model of exercise prescription for a 20-week period (3 times/week). Immediately after a 20-week detraining period (no training was performed) was followed.

Training-Detraining

Control - No training BEHAVIORAL

No training was performed during a 40-week period. Participation only in measurements.

Control

Eligibility Criteria

• Age: 30 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• (a) were sedentary (\<7,500 steps/day; VO2max \<30 ml/kg/min), b) premenopausal women aged 30-45 years, c) were overweight or obese class 1 (BMI=25-34.9 kg/m2), d) were non-smokers for ≥6 months before the study, e) not following a diet intervention or using nutritional supplements/medications before (≥6 months) and during the study, f) had no weight loss greater \>10% of body mass ≤6 months before the study, g) participated in ≥80% of total exercise sessions, and h) had no symptoms of depression.

You may not qualify if:

• a) a recent febrile illness, b) history of muscle lesion, c) lower limb trauma, d) signs, symptoms or diagnosis of serious health complications or physical disability or other medical condition compromising safe participation in exercise training.

Sponsors & Collaborators

• University of Thessaly: lead

Study Sites (1)

Exercise Biochemistry Laboratory, School of Physical Education & Sports Sciences, University of Thessaly

Trikala, Karies, 42100, Greece

Location

Related Publications (5)

• Batrakoulis A, Jamurtas AZ, Georgakouli K, Draganidis D, Deli CK, Papanikolaou K, Avloniti A, Chatzinikolaou A, Leontsini D, Tsimeas P, Comoutos N, Bouglas V, Michalopoulou M, Fatouros IG. High intensity, circuit-type integrated neuromuscular training alters energy balance and reduces body mass and fat in obese women: A 10-month training-detraining randomized controlled trial. PLoS One. 2018 Aug 23;13(8):e0202390. doi: 10.1371/journal.pone.0202390. eCollection 2018.

  PMID: 30138475 RESULT

• Batrakoulis A, Loules G, Georgakouli K, Tsimeas P, Draganidis D, Chatzinikolaou A, Papanikolaou K, Deli CK, Syrou N, Comoutos N, Theodorakis Y, Jamurtas AZ, Fatouros IG. High-intensity interval neuromuscular training promotes exercise behavioral regulation, adherence and weight loss in inactive obese women. Eur J Sport Sci. 2020 Jul;20(6):783-792. doi: 10.1080/17461391.2019.1663270. Epub 2019 Sep 16.

  PMID: 31478436 RESULT

• Batrakoulis A, Tsimeas P, Deli CK, Vlachopoulos D, Ubago-Guisado E, Poulios A, Chatzinikolaou A, Draganidis D, Papanikolaou K, Georgakouli K, Batsilas D, Gracia-Marco L, Jamurtas AZ, Fatouros I. Hybrid neuromuscular training promotes musculoskeletal adaptations in inactive overweight and obese women: A training-detraining randomized controlled trial. J Sports Sci. 2021 Mar;39(5):503-512. doi: 10.1080/02640414.2020.1830543. Epub 2020 Oct 15.

  PMID: 33054601 RESULT

• Batrakoulis A, Jamurtas AZ, Draganidis D, Georgakouli K, Tsimeas P, Poulios A, Syrou N, Deli CK, Papanikolaou K, Tournis S, Fatouros IG. Hybrid Neuromuscular Training Improves Cardiometabolic Health and Alters Redox Status in Inactive Overweight and Obese Women: A Randomized Controlled Trial. Antioxidants (Basel). 2021 Oct 12;10(10):1601. doi: 10.3390/antiox10101601.

  PMID: 34679738 RESULT

• 2020 NSCA Research Abstracts. J Strength Cond Res. 2021 Apr 1;35(4):e3-e288. doi: 10.1519/JSC.0000000000003877. No abstract available.

  PMID: 33752224 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 26, 2017
• First Posted: May 1, 2017
• Study Start: July 1, 2015
• Primary Completion: July 1, 2016
• Study Completion: April 1, 2017
• Last Updated: October 28, 2021

Record last verified: 2021-10

Locations

GR (1)