B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma
polymorphism
B2adrenergic Receptor Gene Polymorphism in Bronchial Asthma: Relation to Disease Severity and Control
1 other identifier
observational
75
1 country
1
Brief Summary
The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection. The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection, Enhanced mucociliary clearance. The b2AR gene is located on chromosome 5q31-q32, a region that is genetically linked to asthma and related phenotypes. There are three best known polymorphisms in the coding region of the b2AR gene that can modulate the function of the receptor.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Apr 2017
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2017
CompletedFirst Submitted
Initial submission to the registry
April 11, 2017
CompletedFirst Posted
Study publicly available on registry
April 18, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
October 30, 2017
CompletedAugust 28, 2017
August 1, 2017
6 months
April 11, 2017
August 25, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
To measure number of patient with homozygous and heterozygous B2AD gene polymorphisms with focus on Arg/Gly16 and Gln/Glu27 polymorphism
study of prevalence homozygote and heterozygote patients
1 month
Secondary Outcomes (1)
Number of patient with b2AR gene polymorphisms in different asthma severity and different response of treatment of asthma ( Arg/Gly16 and Gln/Glu27 polymorphism)
1 month
Eligibility Criteria
Patients diagnosed as asthma according to GINA 2016
You may qualify if:
- patients diagnosed as asthma according to GINA guideline 2016.
- Allergic asthma
You may not qualify if:
- pneumonia
- chronic cardiac, hepatic and renal diseases
- pregnancy and lactation
- malignancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
AssiutU
Asyut, 71111, Egypt
Related Publications (1)
Mohamed-Hussein AAR, Sayed SS, Eldien HMS, Assar AM, Yehia FE. Beta 2 Adrenergic Receptor Genetic Polymorphisms in Bronchial Asthma: Relationship to Disease Risk, Severity, and Treatment Response. Lung. 2018 Dec;196(6):673-680. doi: 10.1007/s00408-018-0153-3. Epub 2018 Sep 3.
PMID: 30178312DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Aliae Mohamed-Hussein
Professor of Pulmonology- Faculty of Medicine-Assiut University
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. Dr. Aliae AR Mohamed-Hussein, Professor of Pulmonology
Study Record Dates
First Submitted
April 11, 2017
First Posted
April 18, 2017
Study Start
April 1, 2017
Primary Completion
October 1, 2017
Study Completion
October 30, 2017
Last Updated
August 28, 2017
Record last verified: 2017-08
Data Sharing
- IPD Sharing
- Will not share