CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma

NCT03110744 | Completed Phase 2 DMC

• 1 other identifier: NCT-2016-415 / Chordoma
• Study Type: interventional
• Target: 43
• Locations: 1 country
• Sites: 3

Brief Summary

In chordoma cell lines and patient biopsies, the p16 (CDKN2A) tumor suppressor is consistently deleted. Thus, chordomas are an example of a tumor with universal activation of the cyclin-dependent kinases 4 and 6 (CDK4/6) pathway, and experiments with patient-derived chordoma cell lines demonstrate aberrant CDK4/6 activity downstream of p16 loss can be efficiently inhibited by the CDK4/6 inhibitor palbociclib, resulting in reduced proliferation and growth of neoplastic cells. The investigators aim to conduct a phase II clinical trial to evaluate the efficacy of the small-molecule CDK4/6 inhibitor palbociclib in patients with locally advanced/metastatic chordoma who are not candidates for standard therapy. The primary objective is disease control in patients with chordoma treated with palbociclib as single agent. The study design of this phase II study is based on a Simon two-stage design.

Conditions

Chordoma

Outcome Measures

Primary Outcomes (1)

• Disease control rate (DCR)

  The primary endpoint is the DCR after six cycles of palbociclib, which is defined as the presence of at least one confirmed complete response (CR) or confirmed partial response (PR) or stable disease (SD) according to RECIST version 1.1.

  6 months

Secondary Outcomes (5)

• Tumor response rate (TRR)

  6 months

• Progression-free survival (PFS)

  6 months

• Overall survival (OS)

  6 months

• Safety (toxicity, tolerability): Toxic effects will be graded according to CTCAE v4.03.

  6 months

• Quality of life (QoL)

  6 months

Study Arms (1)

Palbociclib

EXPERIMENTAL

application on 21 consecutive days of a 28 days cycle

Drug: Palbociclib

Interventions

Palbociclib DRUG

application on 21 consecutive days of a 28 days cycle

Also known as: Ibrance

Palbociclib

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with locally advanced or metastatic chordoma with confirmed diagnosis in a reference pathology (with immunohistology for epithelial membrane antigen, S100, Brachyury, Integrase interactor 1 (INI-1)) not amenable to curative treatment with surgery or radiotherapy
• At least one measurable tumor lesion according to RECIST 1.1 criteria
• Loss of p16 determined immunohistochemically or CDKN2A/B genomically, presence of CDK4/6 and RB1 determined immunohistochemically or by RNA-Sequencing.
• Age ≥ 18 years, no upper age limit
• Availability of tissue blocks preferably not older than 12 months for immunohistologic assessment (if no adequate material is available, re-biopsy should be considered before entering the study)
• No chemotherapy two weeks before study
• Non-pregnant and non-nursing. Women of child-bearing potential must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 72 hours prior to registration (WOCBP is defined as a sexually active mature woman who has not undergone a hysterectomy or who has had menses at any time in the preceding 24 months).
• Women of child-bearing potential must either commit to continued abstinence from heterosexual intercourse or begin one acceptable method of birth control (double barrier contraceptive method (IUD, condome), tubal ligation, or partner's vasectomy) while on therapy and for 14 weeks after the last dose of therapy. Hormonal contraception alone is an inadequate method of birth control. Female patients must agree not to donate lactation during treatment and until 14 weeks after end of treatment.
• Men must agree not to father a child and must use a latex condom during any sexual contact with WOCBP while receiving therapy and for 14 weeks after therapy is stopped, even if they have undergone successful vasectomy. Sperm donation is not permitted for the same time interval.
• Signed written informed consent
• Performance status ≤ 2 according to Eastern Cooperative Oncology Group (ECOG) /World Health Organization (WHO) criteria
• Ability of patient to understand the character and individual consequences of clinical trial

You may not qualify if:

• Prior treatment with palbociclib or known intolerance/allergy to the compound or any ingredient (acquired or hereditary).
• Prior treatment with other CDK4/6 inhibitors
• Co-therapy with strong/potent CYP3A inducers and/or inhibitors, (e.g., Clarithromycin, Indinavir, Itraconazol, Ketoconazol, Lopinavir/Ritonavir, Nefazodon, Nelfinavir, Posaconazol, Saquinavir, Telaprevir, Telithromycin, Voriconazol, and St. John's Wort \[Hypericum perforatum\])) while on treatment with study drug.
• Co-therapy with corticosteroids above 7.5 mg prednisolone/prednisone equivalent
• Anticancer treatment less than 2 weeks prior to study treatment
• Organ insufficiency: creatinine clearance \<30ml/min; total bilirubin \> 1.5x upper normal serum level; AST \> upper normal serum level ; abnormal blood counts; heart failure (New York Heart Association (NYHA) III/IV); uncontrolled hypertension; unstable angina; serious cardiac arrhythmia; severe obstructive or restrictive ventilation disorder
• Clinical signs of active infection (° grade 2-CTCAE Vers.5.0)
• Patients with a "currently active" second malignancy other than non-melanoma skin cancer. Patients are not considered to have a "currently active" malignancy if the patients have completed therapy and are considered by the patients physician to be at less than 30% risk of relapse within one year.
• Severe neurologic or psychiatric disorder interfering with ability of giving informed consent
• Known or suspected active alcohol or drug abuse
• Known positivity for HIV, active hepatitis A virus (HAV), hepatitis B virus (HBV), or hepatitis C virus (HCV) infection
• Cytopenia: platelets \<100 G/l, neutrophils \<1.0 G/l, hemoglobin \<10.0 g/dl
• corrected QT interval (QTc) \>470 msec (based on the mean value of triplicate ECGs), family or personal history of long or short QT syndrome, Brugada syndrome, or known history of QTc prolongation or Torsade de Pointes
• Uncontrolled electrolyte disorders that can aggravate the effects of a QTc-prolonging drug (e.g., hypocalcemia, hypokalemia, hypomagnesemia)
• Participation in other ongoing interventional clinical trials

Sponsors & Collaborators

• University Hospital Heidelberg: lead

Study Sites (3)

Universitätsklinikum Essen

Essen, 45147, Germany

Location

National Center for Tumor Diseases

Heidelberg, 69120, Germany

Location

Universitätsklinikum Ulm

Ulm, 89081, Germany

Location

MeSH Terms

Conditions

Chordoma

Interventions

palbociclib

Condition Hierarchy (Ancestors)

Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms

Study Officials

• Stefan Fröhling, Prof. Dr.

  NCT Heidelberg

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr. med. Richard F. Schlenk (Coordinating Investigator)

Study Record Dates

• First Submitted: March 31, 2017
• First Posted: April 12, 2017
• Study Start: December 15, 2017
• Primary Completion: December 22, 2022
• Study Completion: December 22, 2022
• Last Updated: March 27, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will not share

Locations

DE (3)