Success Metrics

Clinical Success Rate
80.4%

Based on 86 completed trials

Completion Rate
80%(86/107)
Active Trials
93(39%)
Results Posted
71%(61 trials)
Terminated
21(9%)

Phase Distribution

Ph not_applicable
4
2%
Ph phase_1
84
35%
Ph phase_3
24
10%
Ph phase_4
3
1%
Ph early_phase_1
5
2%
Ph phase_2
97
40%

Phase Distribution

89

Early Stage

97

Mid Stage

27

Late Stage

Phase Distribution217 total trials
Early Phase 1First-in-human
5(2.3%)
Phase 1Safety & dosage
84(38.7%)
Phase 2Efficacy & side effects
97(44.7%)
Phase 3Large-scale testing
24(11.1%)
Phase 4Post-market surveillance
3(1.4%)
N/ANon-phased studies
4(1.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

74.8%

86 of 115 finished

Non-Completion Rate

25.2%

29 ended early

Currently Active

93

trials recruiting

Total Trials

241

all time

Status Distribution
Active(99)
Completed(86)
Terminated(29)
Other(27)

Detailed Status

Completed86
Active, not recruiting49
Recruiting44
unknown25
Terminated21
Withdrawn8

Development Timeline

Analytics

Development Status

Total Trials
241
Active
93
Success Rate
80.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 15 (2.3%)
Phase 184 (38.7%)
Phase 297 (44.7%)
Phase 324 (11.1%)
Phase 43 (1.4%)
N/A4 (1.8%)

Trials by Status

unknown2510%
withdrawn83%
recruiting4418%
completed8636%
terminated219%
active_not_recruiting4920%
not_yet_recruiting62%
suspended21%

Recent Activity

Clinical Trials (241)

Showing 20 of 241 trialsScroll for more
NCT07405164Phase 3

Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)

Recruiting
NCT05563220Phase 1

Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer

Active Not Recruiting
NCT07347600

A Study to Evaluate the Effectiveness and Safety of Inavolisib in Participants With Endocrine-resistant, PIK3CA-mutated, Hormone Receptor-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer

Recruiting
NCT05564377Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Recruiting
NCT06126276Phase 2

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Recruiting
NCT03006172Phase 1

To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer

Active Not Recruiting
NCT04802759Phase 1

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

Recruiting
NCT04931342Phase 2

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

Active Not Recruiting
NCT06377852Phase 3

The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

Recruiting
NCT06570031Phase 1

ONO-4578-06:Phase I Study of ONO-4578 and Letrozole Plus CDK4 /6 Inhibitors in Breast Cancer

Completed
NCT02738866Phase 2

Palbociclib With Fulvestrant for Metastatic Breast Cancer After Treatment With Palbociclib and an Aromatase Inhibitor

Active Not Recruiting
NCT07174336Phase 3

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Recruiting
NCT05768139Phase 1

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

Recruiting
NCT06065748Phase 3

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Recruiting
NCT07492641Phase 3

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

Recruiting
NCT04567420Phase 2

DNA-guided Second Line Adjuvant Therapy for High Residual Risk, Estrogen Receptor Positive, HER-2 Negative Breast Cancer (DARE)

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT03155620Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

Active Not Recruiting
NCT02693535Phase 2

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Recruiting
NCT06390839Phase 2

Testing Palbociclib (PD-0332991) as Potentially Targeting Treatment in Cancers With CDK4 or CDK6 Amplification (MATCH - Subprotocol Z1C)

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
241