Success Metrics

Clinical Success Rate
79.6%

Based on 86 completed trials

Completion Rate
80%(86/108)
Active Trials
91(38%)
Results Posted
71%(61 trials)
Terminated
22(9%)

Phase Distribution

Ph phase_1
84
35%
Ph phase_2
97
40%
Ph phase_3
24
10%
Ph phase_4
3
1%
Ph early_phase_1
5
2%
Ph not_applicable
4
2%

Phase Distribution

89

Early Stage

97

Mid Stage

27

Late Stage

Phase Distribution217 total trials
Early Phase 1First-in-human
5(2.3%)
Phase 1Safety & dosage
84(38.7%)
Phase 2Efficacy & side effects
97(44.7%)
Phase 3Large-scale testing
24(11.1%)
Phase 4Post-market surveillance
3(1.4%)
N/ANon-phased studies
4(1.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

74.1%

86 of 116 finished

Non-Completion Rate

25.9%

30 ended early

Currently Active

91

trials recruiting

Total Trials

241

all time

Status Distribution
Active(98)
Completed(86)
Terminated(30)
Other(27)

Detailed Status

Completed86
Active, not recruiting50
Recruiting41
unknown25
Terminated22
Withdrawn8

Development Timeline

Analytics

Development Status

Total Trials
241
Active
91
Success Rate
79.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 15 (2.3%)
Phase 184 (38.7%)
Phase 297 (44.7%)
Phase 324 (11.1%)
Phase 43 (1.4%)
N/A4 (1.8%)

Trials by Status

unknown2510%
completed8636%
not_yet_recruiting73%
terminated229%
withdrawn83%
suspended21%
active_not_recruiting5021%
recruiting4117%

Recent Activity

Clinical Trials (241)

Showing 20 of 241 trialsScroll for more
NCT05564377Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Recruiting
NCT05554367Phase 2

Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial

Active Not Recruiting
NCT06126276Phase 2

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT07174336Phase 3

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Recruiting
NCT06380751Phase 3

Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

Recruiting
NCT03304080Phase 1

Anastrozole, Palbociclib, Trastuzumab and Pertuzumab in HR-positive, HER2-positive Metastatic Breast

Active Not Recruiting
NCT03478514Phase 2

Phase II Palbociclib +Ibrutinib in Mantle Cell Lymphoma

Active Not Recruiting
NCT03155620Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

Active Not Recruiting
NCT07492641Phase 3

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

Recruiting
NCT02942355Phase 2

Trial of Anastrozole and Palbociclib in Metastatic HER2-Negative Breast Cancer

Active Not Recruiting
NCT07683754Phase 3

T-DXd Based Therapy Followed by Endocrine Therapy Plus Dual HER2 Blockade in First-line HER2+/ HR+ Metastatic Breast Cancer and Retreatment With T-DXd

Not Yet Recruiting
NCT05468697Phase 1

A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6482-024/LITESPARK-024)

Active Not Recruiting
NCT03065387Phase 1

Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation

Terminated
NCT05238922Phase 1

Study of INCB123667 in Subjects With Advanced Solid Tumors

Active Not Recruiting
NCT02896335Phase 2

Palbociclib and Pembrolizumab In Central Nervous System Metastases

Recruiting
NCT04360941Phase 1

PAveMenT: Palbociclib and Avelumab in Metastatic AR+ Triple Negative Breast Cancer

Recruiting
NCT06390839Phase 2

Testing Palbociclib (PD-0332991) as Potentially Targeting Treatment in Cancers With CDK4 or CDK6 Amplification (MATCH - Subprotocol Z1C)

Active Not Recruiting
NCT03424005Phase 1

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

Recruiting
NCT04964934Phase 3

Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
241