Success Metrics

Clinical Success Rate
79.8%

Based on 87 completed trials

Completion Rate
80%(87/109)
Active Trials
90(37%)
Results Posted
72%(63 trials)
Terminated
22(9%)

Phase Distribution

Ph phase_1
86
35%
Ph phase_2
97
40%
Ph phase_3
24
10%
Ph phase_4
3
1%
Ph not_applicable
4
2%
Ph early_phase_1
5
2%

Phase Distribution

91

Early Stage

97

Mid Stage

27

Late Stage

Phase Distribution219 total trials
Early Phase 1First-in-human
5(2.3%)
Phase 1Safety & dosage
86(39.3%)
Phase 2Efficacy & side effects
97(44.3%)
Phase 3Large-scale testing
24(11.0%)
Phase 4Post-market surveillance
3(1.4%)
N/ANon-phased studies
4(1.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

74.4%

87 of 117 finished

Non-Completion Rate

25.6%

30 ended early

Currently Active

90

trials recruiting

Total Trials

243

all time

Status Distribution
Active(99)
Completed(87)
Terminated(30)
Other(27)

Detailed Status

Completed87
Active, not recruiting53
Recruiting37
unknown25
Terminated22
Not yet recruiting9

Development Timeline

Analytics

Development Status

Total Trials
243
Active
90
Success Rate
79.8%
Most Advanced
Phase 4

Trials by Phase

Early Phase 15 (2.3%)
Phase 186 (39.3%)
Phase 297 (44.3%)
Phase 324 (11.0%)
Phase 43 (1.4%)
N/A4 (1.8%)

Trials by Status

withdrawn83%
active_not_recruiting5322%
recruiting3715%
not_yet_recruiting94%
suspended21%
completed8736%
terminated229%
unknown2510%

Recent Activity

Clinical Trials (243)

Showing 20 of 243 trialsScroll for more
NCT03478514Phase 2

Phase II Palbociclib +Ibrutinib in Mantle Cell Lymphoma

Active Not Recruiting
NCT05564377Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT06126276Phase 2

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Recruiting
NCT04072952Phase 1

A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Participants With ER+/HER2- Locally Advanced or Metastatic Breast Cancer

Completed
NCT04711252Phase 3

A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease

Active Not Recruiting
NCT05867251Phase 1

Study of AVZO-021 in Patients With Advanced Solid Tumors

Recruiting
NCT07492641Phase 3

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

Recruiting
NCT06377852Phase 3

The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

Recruiting
NCT03573648Phase 2

Neoadjuvant Endocrine Therapy, Palbociclib, Avelumab in Estrogen Receptor Positive Breast Cancer

Active Not Recruiting
NCT05384119Phase 1

Phase 1b/2 Study of TTI-101 in Combination for Patients With Metastatic Hormone Receptor-Positive and HER2-Negative Breast Cancer

Terminated
NCT04224272Phase 2

Phase 2a Study of ZW25 in Combination With Palbociclib Plus Fulvestrant

Completed
NCT04964934Phase 3

Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)

Active Not Recruiting
NCT07174336Phase 3

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Recruiting
NCT04966481Phase 3

Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered, HPV-unrelated Head and Neck Squamous Cell Carcinoma Who Experienced Disease Progression on a PD-1/L1 Inhibitor

Recruiting
NCT03455270Phase 1

G1T48, an Oral SERD, Alone and in Combination With Palbociclib in ER-Positive, HER2-Negative Advanced Breast Cancer

Completed
NCT05694871Phase 2

Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma

Active Not Recruiting
NCT06843967Phase 1

A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

Recruiting
NCT07748208Phase 2

A Study Evaluating the Safety of Inavolisib and Fulvestrant With or Without Palbociclib in Participants With Advanced Breast Cancer (ABC) and Type 2 Diabetes

Not Yet Recruiting
NCT04438824Phase 2

Palbociclib and INCMGA00012 in People With Advanced Liposarcoma

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
243