Central Proprioceptive Processing and Postural Control in LBP

NCT03097718 | Completed DMC

• 1 other identifier: 2016_SBrumagne_PropriocProcess
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This project aims to elucidate neural correlates of proprioceptive deficits in patients with recurrent non-specific low back pain, by studying whether brain activation patterns during the processing of proprioceptive signals from the ankle muscles and lower back muscles are altered compared to healthy control subjects.

Conditions

Low Back Pain

Outcome Measures

Primary Outcomes (2)

• Brain activation during the processing of proprioceptive signals originating in the ankle muscles and lumbar paraspinal muscles

  Brain activation during the processing of proprioceptive signals originating in the ankle muscles (soleus muscle) and lumbar paraspinal muscles (multifidus muscles) is studied by applying muscle vibration to these muscles during fMRI. The test subjects participate in one scanning session, during which three fMRI runs with ankle muscle vibration and three fMRI runs with lumbar paraspinal muscles vibration are made in alternating order. Each fMRI run consists of three conditions: 'muscle vibration at 60 Hz' that stimulates muscle proprioceptors and vibrotactile skin receptors, 'muscle vibration at 20 Hz' that stimulates vibrotactile skin receptors (serves as a control condition) and 'rest'. During each fMRI run, the two 'vibration' conditions are presented three times during 18s-long blocks. Each' vibration' block is followed by a 18s-long 'rest' block.

  One time point, immediately after inclusion in the study

• Proprioceptive use during postural control

  Mean center-of-pressure displacement in response to soleus muscle and/or multifidus muscle vibration (60 Hz, 0.5 mm) during upright standing on two support surfaces. Condition A: stable support surface: * Upright standing, vision occluded (20s) - bilateral soleus and multifidus muscle vibration (15s) - upright standing (20s) * Upright standing, vision occluded (20s) - bilateral soleus muscle vibration (15s) - upright standing (20s) * Upright standing, vision occluded (20s) - bilateral multifidus muscle vibration (15s) - upright standing (20s) Condition B: unstable support surface (Airex balance pad elite): * Upright standing, vision occluded (20s) - bilateral soleus and multifidus muscle vibration (15s) - upright standing (20s) * Upright standing, vision occluded (20s) - bilateral soleus muscle vibration (15s) - upright standing (20s) * Upright standing, vision occluded (20s) - bilateral multifidus muscle vibration (15s) - upright standing (20s)

  One time point, immediately after inclusion in the study

Study Arms (2)

Non-specific low back pain

Individuals with recurrent non-specific low back pain

Healthy control subjects

Healthy individuals without low back pain

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Leuven and surrounding area

You may qualify if:

• Age: 20 - 50 years old
• At least six months of low back pain with or without referred pain to the buttock or thigh
• At least three episodes of disabling low back pain
• A score of at least 14% on the Oswestry Disability Index
• Willing to sign the informed consent
• Meets specific criteria related to MRI-research
• Age: 20 - 50 years old
• No history of low back pain
• A score of 0% on the Oswestry Disability Index
• Willing to sign the informed consent
• Meets specific criteria related to MRI-research

You may not qualify if:

• History of major trauma and/or major orthopedic surgery of the spine, the pelvis or the lower quadrant
• One of the following conditions: Parkinson's disease, multiple sclerosis, Stroke with sequelae
• Radicular symptoms
• Using strong opioid medication or antidepressants
• Neck pain
• Ankle problems

Sponsors & Collaborators

• KU Leuven: lead
• Agentschap voor Innovatie door Wetenschap en Technologie: collaborator

Study Sites (1)

Katholieke Universiteit Leuven

Leuven, 3000, Belgium

Location

Related Publications (4)

• Brumagne S, Janssens L, Janssens E, Goddyn L. Altered postural control in anticipation of postural instability in persons with recurrent low back pain. Gait Posture. 2008 Nov;28(4):657-62. doi: 10.1016/j.gaitpost.2008.04.015. Epub 2008 Jun 9.

  PMID: 18541428 BACKGROUND

• Claeys K, Dankaerts W, Janssens L, Pijnenburg M, Goossens N, Brumagne S. Young individuals with a more ankle-steered proprioceptive control strategy may develop mild non-specific low back pain. J Electromyogr Kinesiol. 2015 Apr;25(2):329-38. doi: 10.1016/j.jelekin.2014.10.013. Epub 2014 Oct 31.

  PMID: 25467548 BACKGROUND

• Claeys K, Brumagne S, Dankaerts W, Kiers H, Janssens L. Decreased variability in postural control strategies in young people with non-specific low back pain is associated with altered proprioceptive reweighting. Eur J Appl Physiol. 2011 Jan;111(1):115-23. doi: 10.1007/s00421-010-1637-x. Epub 2010 Sep 8.

  PMID: 20824281 BACKGROUND

• Brumagne S, Janssens L, Knapen S, Claeys K, Suuden-Johanson E. Persons with recurrent low back pain exhibit a rigid postural control strategy. Eur Spine J. 2008 Sep;17(9):1177-84. doi: 10.1007/s00586-008-0709-7. Epub 2008 Jul 2.

  PMID: 18594876 BACKGROUND

MeSH Terms

Conditions

Low Back Pain

Condition Hierarchy (Ancestors)

Back Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 26, 2017
• First Posted: March 31, 2017
• Study Start: January 1, 2016
• Primary Completion: July 1, 2018
• Study Completion: July 1, 2018
• Last Updated: February 5, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)