Use of the Nine Holes Peg Test in Multiple Sclerosis: Participation of Elementary Neurological Components in the Functional Evaluation of Manual Dexterity

NCT03096977 | Completed

• 1 other identifier: CHUB-Nine Holes Peg Hands
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study lies in the continuity of the study with identification number NCT02805634. It will be performed on the same group of patients and will aim to assess the manual dexterity, in order to better assign kinesitherapy treatments and increase the utilisation capacity of the hand.

Conditions

Multiple Sclerosis

Keywords

Hand dexterity; Multiple sclerosis; Nine Holes Peg

Outcome Measures

Primary Outcomes (5)

• Scale for the assessment and rating of ataxia (SARA)

  Scale for the assessment and rating of ataxia (SARA)

  1 year

• Prehension force

  Prehension force, using a JAMAR hand dynamometer

  1 year

• Tuned fork result

  Vibratory sensibility testing

  1 year

• Sermes and Weinstein test

  Tactile pressure sensation testing

  1 year

• Weber test

  Evaluate the discrimination of 2 motionless points

  1 year

Study Arms (1)

CHUB-TST02 patients

EXPERIMENTAL

All patients who participated in the NCT02805634 (CHUB-TST02) study.

Diagnostic Test: Scale for the assessment and rating of ataxia (SARA); Device: JAMAR hand dynamometer; Device: Vibratory sensibility testing; Device: Sermes and Weinstein test; Device: Weber test

Interventions

Scale for the assessment and rating of ataxia (SARA) DIAGNOSTIC_TEST

Clinical evaluation of the manual dexterity through the SARA scale.

CHUB-TST02 patients

JAMAR hand dynamometer DEVICE

Clinical evaluation of the prehension force using a JAMAR Dynamometer. The prehension effort is made with the arm along the body, forearm horizontal, elbow flexed at 90 degrees, wrist in neutral position. The handle of the dynamometer is set to the second notch. The effort required is maximum effort. Verbal encouragement is given during four successive tentative: the last three are averaged. Each effort will be separated by a rest period of one minute. Interval: 1 min - Repeat: 3 times per hand

CHUB-TST02 patients

Vibratory sensibility testing DEVICE

Test carried out using a tuned fork applied to the styloid radial process. Position of the evaluated: elbow to the body with forearms horizontal and the wrist in neutral position. Stimulate the tuning fork and apply it to the styloid process of the radius. Ask the patient to say when he no longer feels the vibration. Repeat 3 times for each hand.

CHUB-TST02 patients

Sermes and Weinstein test DEVICE

Instrumental, quantitative method of tactile pressure sensation (dermal contact at constant pressure) using monofilaments. The monofilaments bend when a threshold force is applied to them.There is a kit of 5 monofilaments, each one corresponding to a different functional level. Familiarize the patient with the test, eyes open, on a normal healthy side. Determine the level of perception of the healthy side, eyes closed. Start with the finest monofilament. If the answer is negative, go to the next monofilament. The monofilaments applications are randomly made in the Wynn Parry areas, 3 times / area for blue and green filaments, then 1 time / zone for others. The monofilament must be applied in 1.5 sec, held 1.5 sec, removed in 1.5 sec. The patient must give a verbal response "yes" when he perceives the contact and the response time must be less than 3 sec.

CHUB-TST02 patients

Weber test DEVICE

Evaluate the discrimination of 2 motionless points. The tactile discrimination threshold is the smallest distance separating 2 simultaneous stimulations that are located and perceived separately. The pressure stops at the whitening of the skin. The patient should specify if he feels one or two spikes. To determine the discrimination threshold: Perform 10 stimulations of the same spacing in the same area. The smallest interval for which 7 correct answers are obtained is retained as threshold value. Perform the test 3 times.

CHUB-TST02 patients

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• All patients included in the NCT02805634 study

You may not qualify if:

• None

Sponsors & Collaborators

• Brugmann University Hospital: lead

Study Sites (1)

CHU Brugmann

Brussels, 1020, Belgium

Location

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Bernard Dachy, MD

  CHU Brugmann

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Clinic

Study Record Dates

• First Submitted: March 24, 2017
• First Posted: March 31, 2017
• Study Start: March 15, 2017
• Primary Completion: January 30, 2019
• Study Completion: January 30, 2019
• Last Updated: April 17, 2019

Record last verified: 2019-04

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)