NCT03090191

Brief Summary

The Clover trial is evaluating an investigational vaccine that may help to prevent Clostridium difficile infection. Participants in the study are adults 50 years of age and older, who are at risk of developing Clostridium difficile infection. The study will assess whether the vaccine prevents the disease, and whether it is safe and well tolerated. Each subject will receive 3 doses of Clostridium difficile vaccine or placebo and be followed for up to 3 years after vaccination for potential Clostridium difficile infection.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
17,535

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Mar 2017

Longer than P75 for phase_3

Geographic Reach
23 countries

426 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 20, 2017

Completed
4 days until next milestone

First Posted

Study publicly available on registry

March 24, 2017

Completed
5 days until next milestone

Study Start

First participant enrolled

March 29, 2017

Completed
4.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 21, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 21, 2021

Completed
1.1 years until next milestone

Results Posted

Study results publicly available

February 13, 2023

Completed
Last Updated

February 13, 2023

Status Verified

January 1, 2023

Enrollment Period

4.7 years

First QC Date

March 20, 2017

Results QC Date

November 30, 2022

Last Update Submit

January 17, 2023

Conditions

Outcome Measures

Primary Outcomes (10)

  • Number of First Primary Episodes of Clostridium Difficile Infection (CDI) (Definition 1) Follow-up After Dose 3

    CDI definition 1 for a primary episode of CDI (no previous CDI onset in the prior 8 weeks) was defined as either a) presence of diarrhea, defined as passage of 3 or more unformed stools (Bristol stool chart types 5-7) in 24 or fewer consecutive hours, and stool sample that was positive for the toxin B gene (by polymerase chain reaction \[PCR)\] and positive for toxin A and/or toxin B, as measured in the central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, at surgery, or histopathologically; and corresponding stool sample that was positive for the toxin B gene (via PCR) as measured in the central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

    From 14 days after Dose 3 to the end of the surveillance period (mean follow-up after dose 3 was 34.2 months)

  • Number of First Primary Episodes of Clostridium Difficile Infection (CDI) (Definition 1) Follow-up After Dose 2

    CDI definition 1 for a primary episode of CDI (no previous CDI onset in the prior 8 weeks) was defined as either a) presence of diarrhea, defined as passage of 3 or more unformed stools (Bristol stool chart types 5-7) in 24 or fewer consecutive hours, and stool sample that was positive for the toxin B gene (by PCR) and positive for toxin A and/or toxin B, as measured in the central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, at surgery, or histopathologically; and corresponding stool sample that was positive for the toxin B gene (via PCR) as measured in the central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

    From 14 days after Dose 2 to the end of the surveillance period (mean follow-up after dose 2 was 36 months)

  • Percentage of Participants Reporting Local Reactions Within 7 Days After Dose 1

    Local reactions included redness, swelling and pain at injection site. These were recorded by participants in an electronic diary (e-diary). Redness and swelling were measured and recorded in measuring device units. One measuring device unit= 0.5 centimeter (cm) and graded as mild: 2.5 to 5.0 cm, moderate: greater than (\>) 5.0 to 10.0 cm, severe: \>10.0 cm. Grade 4 indicated necrosis or exfoliative dermatitis for redness and necrosis for swelling Pain at injection site was graded as mild: did not interfere with daily activity, moderate: interfered with daily activity, severe: prevented daily activity. Grade 4 indicated emergency room visit or hospitalization.

    Within 7 days after Dose 1 at Month 0

  • Percentage of Participants Reporting Local Reactions Within 7 Days After Dose 2

    Local reactions included redness, swelling and pain at injection site. These were recorded by participants in an e-diary. Redness and swelling were measured and recorded in measuring device units. One measuring device unit= 0.5 cm and graded as mild: 2.5 to 5.0 cm, moderate: \> 5.0 to 10.0 cm, severe: \>10.0 cm. Grade 4 indicated necrosis or exfoliative dermatitis for redness and necrosis for swelling. Pain at injection site was graded as mild: did not interfere with daily activity, moderate: interfered with daily activity, severe: prevented daily activity. Grade 4 indicated emergency room visit or hospitalization.

    Within 7 days after Dose 2 at Month 1

  • Percentage of Participants Reporting Local Reactions Within 7 Days After Dose 3

    Local reactions included redness, swelling and pain at injection site. These were recorded by participants in an e-diary. Redness and swelling were measured and recorded in measuring device units. One measuring device unit= 0.5 cm and graded as mild: 2.5 to 5.0 cm, moderate: \> 5.0 to 10.0 cm, severe: \>10.0 cm. Grade 4 indicated necrosis or exfoliative dermatitis for redness and necrosis for swelling. Pain at injection site was graded as mild: did not interfere with daily activity, moderate: interfered with daily activity, severe: prevented daily activity. Grade 4 indicated emergency room visit or hospitalization.

    Within 7 days after Dose 3 at Month 6

  • Percentage of Participants Reporting Systemic Events Within 7 Days After Dose 1

    Systemic events included fever, fatigue, headache, joint pain, muscle pain and vomiting. These were recorded by participants in an e-diary. Fever was categorized as: mild: (38.0 to 38.4 degree Celsius \[deg C\]), moderate: (38.5 to 38.9 deg C), severe (39.0 to 40.0 deg C), potentially life threatening (\> 40.0 deg C). Fatigue, headache, joint pain and muscle pain were graded as mild: did not interfere with activity, moderate: some interference with activity, severe: prevented daily activity, grade 4: emergency room visit or hospitalization. Vomiting was graded as mild: 1 to 2 times in 24 hours, moderate: \>2 times in 24 hours, severe: required intravenous hydration, grade 4: emergency room visit or hospitalization for hypotensive shock.

    Within 7 days after Dose 1 at Month 0

  • Percentage of Participants Reporting Systemic Events Within 7 Days After Dose 2

    Systemic events included fever, fatigue, headache, joint pain, muscle pain and vomiting. These were recorded by participants in an e-diary. Fever was categorized as: mild: (38.0 to 38.4 deg C), moderate: (38.5 to 38.9 deg C), severe (39.0 to 40.0 deg C), potentially life threatening (\> 40.0 deg C). Fatigue, headache, joint pain and muscle pain were graded as mild: did not interfere with activity, moderate: some interference with activity, severe: prevented daily activity, grade 4: emergency room visit or hospitalization. Vomiting was graded as mild: 1 to 2 times in 24 hours, moderate: \>2 times in 24 hours, severe: required intravenous hydration, grade 4: emergency room visit or hospitalization for hypotensive shock.

    Within 7 days after Dose 2 at Month 1

  • Percentage of Participants Reporting Systemic Events Within 7 Days After Dose 3

    Systemic events included fever, fatigue, headache, joint pain, muscle pain and vomiting. These were recorded by participants in an e-diary. Fever was categorized as: mild: (38.0 to 38.4 deg C), moderate: (38.5 to 38.9 deg C), severe (39.0 to 40.0 deg C), potentially life threatening (\> 40.0 deg C). Fatigue, headache, joint pain and muscle pain were graded as mild: did not interfere with activity, moderate: some interference with activity, severe: prevented daily activity, grade 4: emergency room visit or hospitalization. Vomiting was graded as mild: 1 to 2 times in 24 hours, moderate: \>2 times in 24 hours, severe: required intravenous hydration, grade 4: emergency room visit or hospitalization for hypotensive shock.

    Within 7 days after Dose 3 at Month 6

  • Number of Participants Reporting Adverse Events (AEs)

    An AE was defined as any untoward medical occurrence in a participant who received investigational product without regard to possibility of causal relationship. AEs included both serious and all non-serious adverse events. An SAE was defined as any untoward medical occurrence at any dose that resulted in any of the following outcomes: death; life-threatening (immediate risk of death); required inpatient hospitalization or prolongation of existing hospitalization; persistent or significant disability/incapacity (substantial disruption of the ability to conduct normal life functions); congenital anomaly/birth defect; or that was considered as an important medical event. AEs included both SAEs and all Non-SAEs (except local and systemic events).

    From Day 1 of Dose 1 to 1 Month after Dose 3 (7 Months)

  • Number of Participants Reporting Serious Adverse Events (SAEs)

    An SAE was defined as any untoward medical occurrence at any dose that resulted in any of the following outcomes: death; life-threatening (immediate risk of death); required inpatient hospitalization or prolongation of existing hospitalization; persistent or significant disability/incapacity (substantial disruption of the ability to conduct normal life functions); congenital anomaly/birth defect; or that was considered as an important medical event.

    From Day 1 of Dose 1 up to 6 months after Dose 3 (up to Month 12)

Secondary Outcomes (8)

  • Number of All Episodes of CDI (Definition 1 and 2) After Dose 3

    From 14 days after Dose 3 to the end of the surveillance period (mean follow-up after dose 3 was 34.2 months)

  • Time to Resolution for Participants With First Primary Episodes of CDI (Definition 1) After Dose 3

    From 14 days after Dose 3 to the end of the surveillance period (mean follow-up after dose 3 was 34.2 months)

  • Proportion of Participants Who Required Medical Attention During First Primary Episode of CDI (Definition 1) After Dose 3

    From 14 days after Dose 3 to the end of the surveillance period (mean follow-up after dose 3 was 34.2 months)

  • Number of Participants With Recurrent Episodes of CDI (Definition 2) After Dose 3

    From 14 days after Dose 3 to the end of the surveillance period (mean follow-up after dose 3 was 34.2 months)

  • Number of All Episodes of CDI (Definition 1 and 2) After Dose 2

    From 14 days after Dose 2 to the end of the surveillance period (mean follow-up after dose 2 was 36 months)

  • +3 more secondary outcomes

Study Arms (2)

Clostridium difficile vaccine

EXPERIMENTAL
Biological: Clostridium difficile vaccine

Placebo

PLACEBO COMPARATOR
Biological: Placebo

Interventions

Toxoid-based Clostridium difficile vaccine

Clostridium difficile vaccine
PlaceboBIOLOGICAL

Normal saline solution (0.9% sodium chloride)

Placebo

Eligibility Criteria

Age50 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Evidence of a personally signed and dated informed consent document.
  • Willing and able to comply with study procedures.
  • Subjects with an increased risk of future contact with healthcare systems or subjects who have received systemic antibiotics in the previous 12 weeks.
  • Ability to be contacted by telephone during study participation.
  • Negative urine pregnancy test for female subjects of childbearing potential.

You may not qualify if:

  • Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or subjects who are Pfizer employees, including their family members, directly involved in the conduct of the study.
  • Participation in other studies involving investigational drug(s)/vaccine(s) within 28 days prior to study entry until 1 month after the third vaccination.
  • Previous administration of an investigational C difficile vaccine or C difficile mAb therapy.
  • Prior episode of CDI..
  • Receipt of blood products or immunoglobulins within 6 months before enrollment.
  • Subjects who may be unable to respond to vaccination due to:
  • Metastatic malignancy; or
  • End-stage renal disease; or
  • Any serious medical disorder likely to be fatal within the next 12 months; or
  • Congenital or acquired immunodeficiency; or
  • Receipt of high dose systemic corticosteroids for 14 days within 28 days of enrollment; or
  • Receipt of chronic systemic treatment with other known immunosuppressant medications, or radiotherapy, within 6 months of enrollment.
  • Known infection with human immunodeficiency virus (HIV).
  • Any bleeding disorder or anticoagulant therapy that would contraindicate intramuscular injection.
  • Any contraindication to vaccination or vaccine components, including previous anaphylactic reaction to any vaccine or vaccine-related components.
  • +4 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (426)

North Alabama Research Center, LLC

Athens, Alabama, 35611, United States

Location

Medical Affiliated Research Center, Inc.

Huntsville, Alabama, 35801, United States

Location

Coastal Clinical Research, LLC, An AMR Company

Mobile, Alabama, 36608, United States

Location

The Pain Center of Arizona

Peoria, Arizona, 85381, United States

Location

Phoenix VA Health Care System

Phoenix, Arizona, 85012, United States

Location

Phoenix Clinical LLC

Phoenix, Arizona, 85014, United States

Location

MedPharmics, LLC

Phoenix, Arizona, 85015, United States

Location

Hope Research Institute

Phoenix, Arizona, 85018, United States

Location

The Pain Center of Arizona

Phoenix, Arizona, 85018, United States

Location

Clinical Research Institute of Arizona, LLC

Surprise, Arizona, 85374, United States

Location

Baptist Health Center for Clinical Research

Little Rock, Arkansas, 72205, United States

Location

Baptist Health Rehabilitation Institute

Little Rock, Arkansas, 72205, United States

Location

Arkansas Gastroenterology

North Little Rock, Arkansas, 72117, United States

Location

California Kidney Specialist

Covina, California, 91723, United States

Location

Usborne Family Medicine

Covina, California, 91724, United States

Location

Kaiser Permanente Daly City

Daly City, California, 94015, United States

Location

Premier Health Research Center, LLC

Downey, California, 90241, United States

Location

Paradigm Clinical Research Centers, Inc.

La Mesa, California, 91942, United States

Location

VA Loma Linda Healthcare System Research Pharmacy

Loma Linda, California, 92357, United States

Location

VA Loma Linda Healthcare System

Loma Linda, California, 92357, United States

Location

Long Beach Clinical Trials Services, Inc.

Long Beach, California, 90806, United States

Location

Long Beach Clinical Trials

Long Beach, California, 90806, United States

Location

VA Long Beach Healthcare System

Long Beach, California, 90822, United States

Location

Academic Medical Research Institute

Los Angeles, California, 90022, United States

Location

Ronald Reagan UCLA Medical Center

Los Angeles, California, 90095, United States

Location

UCLA CTRC Outpatient Unit

Los Angeles, California, 90095, United States

Location

VA Northern California Health Care System

Mather, California, 95655, United States

Location

Veterans Affairs Palo Alto Health Care System

Palo Alto, California, 94304, United States

Location

Covigilant Research, LLC

Rancho Mirage, California, 92270, United States

Location

Paradigm Clinical Research Centers, Inc.

Redding, California, 96001, United States

Location

VA Loma Linda Healthcare System Ambulatory Care System

Redlands, California, 92373, United States

Location

Covigilant Research LLC

Riverside, California, 92506, United States

Location

Kaiser Permanente Roseville

Roseville, California, 95661, United States

Location

One Community Health

Sacramento, California, 95811, United States

Location

Kaiser Permanente Sacramento

Sacramento, California, 95815, United States

Location

CTSC Clinical Research Center

Sacramento, California, 95817, United States

Location

Lawrence J. Ellison Ambulatory Care Center

Sacramento, California, 95817, United States

Location

University of California, Davis Medical Center

Sacramento, California, 95817, United States

Location

Kaiser Permanente South Sacramento

Sacramento, California, 95823, United States

Location

Breakthrough Clinical Trials

San Bernardino, California, 92408, United States

Location

VA San Diego Healthcare System

San Diego, California, 92161, United States

Location

California Kidney Specialists

San Dimas, California, 91773, United States

Location

Kaiser Permanente San Jose

San Jose, California, 95119, United States

Location

Kaiser Permanente Santa Clara

Santa Clara, California, 95051, United States

Location

Alta California Medical Group

Simi Valley, California, 93065, United States

Location

Kaiser Permanente Walnut Creek

Walnut Creek, California, 94596, United States

Location

Clinical Trial Center University of Colorado Denver, School of Medicine

Aurora, Colorado, 80045, United States

Location

University of Colorado Clinical & Translational Research Center Clinic

Aurora, Colorado, 80045, United States

Location

University of Colorado Clinical & Translational Research Center Outpatient Clinic

Aurora, Colorado, 80045, United States

Location

University of Colorado Denver, School of Medicine

Aurora, Colorado, 80045, United States

Location

University of Colorado Department of AIP 2. Pharmacy Bulk Storage

Aurora, Colorado, 80045, United States

Location

Gastroenterology Center of Connecticut, PC

Hamden, Connecticut, 06518, United States

Location

Medical Research Center of Connecticut, LLC

Hamden, Connecticut, 06518, United States

Location

Clinical Research Consulting, LLC

Milford, Connecticut, 06460, United States

Location

Bay Pines VA Healthcare System

Bay Pines, Florida, 33744, United States

Location

Florida Sleep Disorder Center of Brandon

Brandon, Florida, 33511, United States

Location

Teradan Clinical Trials

Brandon, Florida, 33511, United States

Location

Southeast Clinical Research

Chiefland, Florida, 32626, United States

Location

Innovative Research of West FL., Inc.

Clearwater, Florida, 33756, United States

Location

Alliance for Multispecialty Reseach, LLC

Coral Gables, Florida, 33134, United States

Location

Omega Research Consultants, LLC

DeBary, Florida, 32713, United States

Location

Accel Research Sites - DeLand Clinical Research Unit

DeLand, Florida, 32720, United States

Location

Fleming Island Center for Clinical Research

Fleming Island, Florida, 32003, United States

Location

Malcom Randall VA Medical Center Investigational Drug Services

Gainesville, Florida, 32608, United States

Location

Malcom Randall VA Medical Center

Gainesville, Florida, 32608, United States

Location

Indago Research & Health Center, Inc

Hialeah, Florida, 33012, United States

Location

Clinical Neuroscience Solutions,Inc.

Jacksonville, Florida, 32256, United States

Location

Multi-Specialty Research Associates, Inc.

Lake City, Florida, 32055, United States

Location

Optimus U. Corp.

Miami, Florida, 33125, United States

Location

Finlay Medical Research

Miami, Florida, 33126, United States

Location

Doctors Research Institute

Miami, Florida, 33135, United States

Location

Acevedo Clinical Research Associates

Miami, Florida, 33142, United States

Location

Next Phase Research Alliance

Miami, Florida, 33144, United States

Location

Charisma Medical and Research Center

Miami Lakes, Florida, 33014, United States

Location

Ocean Blue Medical Research Center, Inc.

Miami Springs, Florida, 33166, United States

Location

Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

Orlando, Florida, 32801, United States

Location

HMD Research LLC

Orlando, Florida, 32819, United States

Location

Pines Care Research Center, LLC

Pembroke Pines, Florida, 33026, United States

Location

Progressive Medical Research

Port Orange, Florida, 32127, United States

Location

Precision Clinical Research, LLC

Sunrise, Florida, 33351, United States

Location

Soma Medical Center

West Palm Beach, Florida, 33406, United States

Location

Atlanta VA Medical Center

Decatur, Georgia, 30033, United States

Location

Meridian Clinical Research

Savannah, Georgia, 31406, United States

Location

Clinical Research Atlanta

Stockbridge, Georgia, 30281, United States

Location

East-West Medical Research Institute

Honolulu, Hawaii, 96814, United States

Location

Snake River Research, PLLC

Idaho Falls, Idaho, 83404, United States

Location

Advanced Clinical Research

Meridian, Idaho, 83642, United States

Location

Solaris Clinical Research

Meridian, Idaho, 83646, United States

Location

Christie Clinic, LLC

Champaign, Illinois, 61822, United States

Location

Edward Hines Jr VA Hospital

Hines, Illinois, 60141, United States

Location

Springfield Clinic Infectious Diseases

Springfield, Illinois, 62702, United States

Location

Community Clinical Research Center

Anderson, Indiana, 46011, United States

Location

Infectious Disease of Indiana, PSC

Carmel, Indiana, 46032, United States

Location

St. Vincent Outpatient Treatment Center

Carmel, Indiana, 46032, United States

Location

Deaconess Clinic Mt. Pleasant

Evansville, Indiana, 47725, United States

Location

St. Vincent Hospital & Health Care Center

Indianapolis, Indiana, 46260, United States

Location

St. Vincent Hospital and Health Care Center

Indianapolis, Indiana, 46260, United States

Location

MOC Research

Mishawaka, Indiana, 46544, United States

Location

Meridian Clinical Research

Sioux City, Iowa, 51106, United States

Location

Alliance for Multispecialty Research, LLC

Wichita, Kansas, 67205, United States

Location

Kentucky Pediatric/Adult Research

Bardstown, Kentucky, 40004, United States

Location

Central Kentucky Research Associates, LLC

Lexington, Kentucky, 40509, United States

Location

Tandem Clinical Research, LLC

Marrero, Louisiana, 70072, United States

Location

MedPharmics, LLC

Metairie, Louisiana, 70006, United States

Location

Barnum Medical Research Inc

Natchitoches, Louisiana, 71457, United States

Location

Ochsner Center for Primary Care and Wellness

New Orleans, Louisiana, 70121, United States

Location

Ochsner Clinic Foundation

New Orleans, Louisiana, 70121, United States

Location

Luminis Health Anne Arundel Medical Center Infusion Center

Annapolis, Maryland, 21401, United States

Location

Luminis Health Anne Arundel Medical Center

Annapolis, Maryland, 21401, United States

Location

Luminis Health Research Institute: Research Office

Annapolis, Maryland, 21401, United States

Location

VA Ann Arbor Healthcare System

Ann Arbor, Michigan, 48105, United States

Location

ClinSite, LLC

Canton, Michigan, 48187, United States

Location

Aa Mrc Llc

Flint, Michigan, 48504, United States

Location

Revival Research Institute, LLC

Sterling Heights, Michigan, 48313, United States

Location

Mayo Clinic Rochester, Methodist Hospital Campus

Rochester, Minnesota, 55902, United States

Location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Location

MedPharmics

Gulfport, Mississippi, 39503, United States

Location

Center for Outpatient Health

St Louis, Missouri, 63108, United States

Location

Washington University School of Medicine

St Louis, Missouri, 63110-1093, United States

Location

Barnes Jewish Hospital

St Louis, Missouri, 63110, United States

Location

Barnes-Jewish Hospital

St Louis, Missouri, 63110, United States

Location

Center for Advanced Medicine

St Louis, Missouri, 63110, United States

Location

Center For Clinical Studies

St Louis, Missouri, 63110, United States

Location

Sundance Clinical Research

St Louis, Missouri, 63141, United States

Location

Bozeman Health Deaconess Hospital d/b/a Bozeman Health Clinical Research

Bozeman, Montana, 59715, United States

Location

Bozeman Health GI Clinic

Bozeman, Montana, 59715, United States

Location

Mercury Street Medical Group, PLLC

Butte, Montana, 59701, United States

Location

Meridian Clinical Research, LLC

Norfolk, Nebraska, 68701, United States

Location

Barrett Clinic

Omaha, Nebraska, 68128, United States

Location

Meridian Clinical Research, LLC

Omaha, Nebraska, 68134, United States

Location

ID Care

Hillsborough, New Jersey, 08844, United States

Location

Amici Clinical Research

Raritan, New Jersey, 08869, United States

Location

South Jersey Infectious Disease

Somers Point, New Jersey, 08244, United States

Location

New Mexico VA Healthcare System

Albuquerque, New Mexico, 87108, United States

Location

Meridian Clinical Research LLC

Binghamton, New York, 13901, United States

Location

Meridian Clinical Research, LLC

Endwell, New York, 13760, United States

Location

Rochester Clinical Research

Rochester, New York, 14609, United States

Location

PMG Research of Raleigh, LLC d/b/a PMG Research of Cary

Cary, North Carolina, 27518, United States

Location

PMG Research of Charlotte, LLC

Charlotte, North Carolina, 28209, United States

Location

Durham VAMC

Durham, North Carolina, 27705, United States

Location

Duke Early Phase Clinical Research

Durham, North Carolina, 27710, United States

Location

Duke University Hospital Investigational Drug Services (IDS) Pharmacy

Durham, North Carolina, 27710, United States

Location

PharmQuest

Greensboro, North Carolina, 27408, United States

Location

PMG Research of Hickory, LLC

Hickory, North Carolina, 28601, United States

Location

PMG Research of Raleigh, LLC

Raleigh, North Carolina, 27609, United States

Location

Wake Research Associates, LLC

Raleigh, North Carolina, 27612, United States

Location

PMG Research of Rocky Mount, LLC

Rocky Mount, North Carolina, 27804, United States

Location

PMG Research of Salisbury, LLC

Salisbury, North Carolina, 28144, United States

Location

Waterway Primary Care LLC DBA Tabor City Family Medicine

Tabor City, North Carolina, 28463, United States

Location

PMG Research of Wilmington, LLC

Wilmington, North Carolina, 28401, United States

Location

PMG Research of Winston-Salem, LLC

Winston-Salem, North Carolina, 27103, United States

Location

Progressive Medicine of the Triad, LLC

Winston-Salem, North Carolina, 27103, United States

Location

Lillestol Research LLC

Fargo, North Dakota, 58104, United States

Location

Aultman Cardiology Clinical Trials

Canton, Ohio, 44710, United States

Location

Aultman Hospital

Canton, Ohio, 44710, United States

Location

UC Health Physicians Office Clifton

Cincinnati, Ohio, 45219, United States

Location

University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States

Location

Sterling Research Group, Ltd.

Cincinnati, Ohio, 45246, United States

Location

University Of Cincinnati-Internal Medicine Division of Digestive Diseases

Cincinnati, Ohio, 45267, United States

Location

Louis Stokes Cleveland VA Medical Center

Cleveland, Ohio, 44106, United States

Location

University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States

Location

Velocity Clinical Research, Inc.

Cleveland, Ohio, 44122, United States

Location

OhioHealth Riverside Methodist Hospital

Columbus, Ohio, 43214, United States

Location

Riverside Methodist Hospital

Columbus, Ohio, 43214, United States

Location

Remington-Davis, Incorporated

Columbus, Ohio, 43215, United States

Location

PriMED Clinical Research

Dayton, Ohio, 45419, United States

Location

Great Lakes Medical Research LLC

Mentor, Ohio, 44060, United States

Location

IPS Research Company

Oklahoma City, Oklahoma, 73103, United States

Location

Kaiser Permanente Center For Health Research

Portland, Oregon, 97227, United States

Location

Columbia Research Group, Inc.

Portland, Oregon, 97239, United States

Location

VA Portland Healthcare System

Portland, Oregon, 97239, United States

Location

Lehigh Valley Health Network/Network Office of Research and Innovation

Allentown, Pennsylvania, 18103, United States

Location

Capital Area Research, LLC

Camp Hill, Pennsylvania, 17011, United States

Location

Westminster Family Medicine

Erie, Pennsylvania, 16506, United States

Location

Liberty Family Practice

Erie, Pennsylvania, 16508, United States

Location

Drexel University College of Medicine

Philadelphia, Pennsylvania, 19102, United States

Location

VA Pittsburgh Healthcare System

Pittsburgh, Pennsylvania, 15240, United States

Location

Preferred Primary Care Physicians, Inc.

Pittsburgh, Pennsylvania, 15243, United States

Location

Preferred Primary Care Physicians, Inc.

Uniontown, Pennsylvania, 15401, United States

Location

Velocity Clinical Research, Providence

East Greenwich, Rhode Island, 02818, United States

Location

Medical Research South, LLC

Charleston, South Carolina, 29414, United States

Location

Main Street Physician's Care - Waterway

Little River, South Carolina, 29566, United States

Location

Coastal Carolina Research Center

North Charleston, South Carolina, 29405, United States

Location

Holston Medical Group

Bristol, Tennessee, 37620, United States

Location

Internal Medicine and Pediatric Associates of Bristol, PC

Bristol, Tennessee, 37620, United States

Location

PMG Research of Bristol, LLC

Bristol, Tennessee, 37620, United States

Location

PMG Research, Inc. d/b/a PMG Research of Knoxville

Knoxville, Tennessee, 37912, United States

Location

PMG Research,Inc. d/b/a PMG Research of Knoxville

Knoxville, Tennessee, 37938, United States

Location

Clinical Neuroscience Solutions, Inc.

Memphis, Tennessee, 38119, United States

Location

Trinity Clinical Research

Tullahoma, Tennessee, 37388, United States

Location

Tekton Research, Inc.

Austin, Texas, 78745, United States

Location

North Texas Infectious Diseases Consultants, P.A.

Dallas, Texas, 75246, United States

Location

Synexus US, LP

Dallas, Texas, 75324, United States

Location

Texas Health Care, PLLC

Fort Worth, Texas, 76104, United States

Location

Ventavia Research Group, LLC

Fort Worth, Texas, 76104, United States

Location

University of North Texas Health Science Center at Fort Worth

Fort Worth, Texas, 76107, United States

Location

University of Texas Medical Branch

Galveston, Texas, 77555, United States

Location

Kelsey Research Foundation

Houston, Texas, 77025, United States

Location

Kelsey-Seybold Clinic

Houston, Texas, 77025, United States

Location

Texas Center for Drug Development, Inc.

Houston, Texas, 77081, United States

Location

Synexus US, dba Research Across America

Mesquite, Texas, 75149, United States

Location

LinQ Research, LLC

Pearland, Texas, 77584, United States

Location

Clinical Trials of Texas, Inc.

San Antonio, Texas, 78229, United States

Location

Diagnostics Research Group

San Antonio, Texas, 78229, United States

Location

South Texas Veterans Healthcare System, Audie L Murphy Hospital

San Antonio, Texas, 78229, United States

Location

DM Clinical Research

Tomball, Texas, 77375, United States

Location

Martin Diagnostic Clinic

Tomball, Texas, 77375, United States

Location

J. Lewis Research Inc. / Foothill Family Clinic Draper

Draper, Utah, 84020, United States

Location

Advanced Clinical Research/Gut Whisperer

Riverton, Utah, 84065, United States

Location

J. Lewis Research, Inc./Foothill Family Clinic

Salt Lake City, Utah, 84109, United States

Location

J Lewis Research, Incorporated

Salt Lake City, Utah, 84121, United States

Location

J. Lewis Research, Inc. - Jordan River Family Medicine

South Jordan, Utah, 84095, United States

Location

Clinical Alliance for Research & Education - Infectious Diseases, LLC

Annandale, Virginia, 22003, United States

Location

Virginia Research Center LLC

Midlothian, Virginia, 23114, United States

Location

Salem VAMC

Salem, Virginia, 24153, United States

Location

Frandsen Family Medicine DBA Sound Medical Research

Port Orchard, Washington, 98366, United States

Location

MultiCare Institute for Research & Innovation

Tacoma, Washington, 98405, United States

Location

Universal Research Group, LLC

Tacoma, Washington, 98405, United States

Location

Wenatchee Valley Hospital & Clinics

Wenatchee, Washington, 98801, United States

Location

Marshfield Medical Center - Marshfield

Marshfield, Wisconsin, 54449, United States

Location

Hospital Aleman

C.a.b.a., Buenos Aires, C1118AAT, Argentina

Location

Hospital Italiano de Buenos Aires

C.a.b.a., Buenos Aires, C1199ABB, Argentina

Location

Centro Médico Dra. De Salvo

C.a.b.a., Buenos Aires, C1426ABP, Argentina

Location

Sanatorio Británico S.A.

Rosario, Santa Fe Province, S2000CVB, Argentina

Location

Hospital Nuestra Senora de la Misericordia

Córdoba, X5000JRD, Argentina

Location

Paratus Clinical Pty Ltd

Kanwal, New South Wales, 2259, Australia

Location

Australian Clinical Research Network

Maroiubra, New South Wales, 2035, Australia

Location

Maroubra Medical Centre

Maroubra, New South Wales, 2035, Australia

Location

University Clinic Pharmacy

Westmead, New South Wales, 2145, Australia

Location

Westmead Hospital

Westmead, New South Wales, 2145, Australia

Location

Austrials Pty Ltd

Sherwood, Queensland, 4075, Australia

Location

Mater Misericordiae Ltd & Mater Medical Research Institute Ltd

South Brisbane, Queensland, 4101, Australia

Location

Eastern Health - Box Hill Hospital

Box Hill, Victoria, 3128, Australia

Location

Emeritus Research

Camberwell, Victoria, 3124, Australia

Location

Barwon Health

Geelong, Victoria, 3220, Australia

Location

Linear Clinical Research

Nedlands, Western Australia, 6009, Australia

Location

Australian Clinical Research Network

Maroubra, 2035, Australia

Location

Institut Jules Bordet

Brussels, 1000, Belgium

Location

UZ Leuven

Leuven, 3000, Belgium

Location

CHU de Liège - Domaine universitaire du Sart Tilman

Liège, 4000, Belgium

Location

"MHAT- Dr. Hristo Stambolski" EOOD

Kazanlak, 6100, Bulgaria

Location

MHAT ''Sv.Ivan Rilski-Kozloduy'' EOOD; Internal Department

Kozloduy, 3320, Bulgaria

Location

MHAT "Sv. Nikolay Chudotvorets" EOOD

Lom, 3600, Bulgaria

Location

UMHAT "Dr. Georgi Stranski" EAD, Second Psychiatric Clinic of general psychiatry and dependence

Pleven, 5800, Bulgaria

Location

UMHAT "Sveti Georgi" EAD

Plovdiv, 4002, Bulgaria

Location

"Center for Mental Health - Ruse" EOOD

Rousse, 7000, Bulgaria

Location

SHATPPD Dr. Dimitar Gramatikov - Ruse EOOD

Rousse, 7002, Bulgaria

Location

''Medical Center-1-Sevlievo'' EOOD

Sevlievo, 5400, Bulgaria

Location

MHAT -Silistra AD

Silistra, 7500, Bulgaria

Location

MC ''Tsaritsa Yoanna''EOOD

Sliven, 8800, Bulgaria

Location

MC 'Cardiohelp' EOOD

Sofia, 1142, Bulgaria

Location

"Acibadem City Clinic University Hospital" EOOD

Sofia, 1407, Bulgaria

Location

Acibadem City Clinic Tokuda Ead

Sofia, 1407, Bulgaria

Location

MHAT "Sveta Anna - Sofia" AD, Clinic of Internal Diseases

Sofia, 1750, Bulgaria

Location

"SHATPD-Troyan" EOOD

Troyan Municipality, 5600, Bulgaria

Location

MC Medica Plus OOD

Veliko Tarnovo, 5000, Bulgaria

Location

MHAT ''Sveta Petka" AD

Vidin, 3700, Bulgaria

Location

Vancouver Coastal Health Research Institution-clinical research unit-Diamond Health Care Centre

Vancouver, British Columbia, V5Z1M9, Canada

Location

The Ottawa Hospital General Campus

Ottawa, Ontario, K1H 8L6, Canada

Location

The Ottawa Hospital Civic Campus

Ottawa, Ontario, K1Y 4E9, Canada

Location

Manna Research Inc. (Toronto)

Toronto, Ontario, M9W4L6, Canada

Location

Intermed Groupe Santé

Chicoutimi, Quebec, G7H 7Y8, Canada

Location

Q & T Research Outaouais Inc.

Gatineau, Quebec, J8Y 6S8, Canada

Location

Centre Integre de Sante et de Services Sociaux de la Monteregie- Center- Hopital Charles LeMoyne

Greenfield Park, Quebec, J4V 2H1, Canada

Location

Centre de recherche du CHU de Quebec-Universite Laval

Québec, Quebec, G1E7G9, Canada

Location

Centre de recherche Saint-Louis

Québec, Quebec, G1W 4R4, Canada

Location

ALPHA Recherche Clinique

Québec, Quebec, G3K 2P8, Canada

Location

CIUSSS de l'Estrie - CHUS

Sherbrooke, Quebec, J1H5N4, Canada

Location

Centre Integre Universitaire de Santé et de Services Sociaux de la Mauricie et du Centre du Québec

Trois-Rivières, Quebec, G8Z 3R9, Canada

Location

Psicomed Esudios Medicos

Antofagasta, Antofagasta, 1270244, Chile

Location

Centro de Investigacion Clínica del Sur

Temuco, IX Region de LA Araucania, 4781156, Chile

Location

Hospital Dr. Hernan Henriquez Aravena

Temuco, Región de la Araucanía, 4781151, Chile

Location

Biomedica Research Group

Santiago, Santiago Metropolitan, 7500710, Chile

Location

Fundacion Arriaran

Santiago, Santiago Metropolitan, 8360159, Chile

Location

Hospital Pablo Tobon Uribe

Medellín, Antioquia, 050001, Colombia

Location

Fundacion Centro de Investigacion Clinica - CIC

Medellín, Antioquia, 050021, Colombia

Location

Instituto de Coloproctologia ICO

Medellín, Antioquia, 050025, Colombia

Location

Clinica de la Costa Ltda.

Barranquilla, Atlántico, 080020, Colombia

Location

Asociación IPS Médicos Internistas de Caldas

Manizales, Caldas Department, 170004, Colombia

Location

Centro de Investigaciones - MedPlus Centro de Recuperación Integral S.A.S.

Bogotá, D.C., 110221, Colombia

Location

Fundación Cardiomet CEQUIN

Armenia, Quindío Department, 630004, Colombia

Location

Fundacion Cardiovascular de Colombia

Floridablanca, Santander Department, 681002, Colombia

Location

Fundacion Valle del Lili

Cali, Valle del Cauca Department, 760032, Colombia

Location

Centro Medico Imbanaco de Cali S.A.

Cali, Valle del Cauca Department, 760043, Colombia

Location

Doktor Brno s.r.o.

Brno, Czech, 65622, Czechia

Location

Ordinace vseobecneho praktickeho lekare

Benátky nad Jizerou, 29471, Czechia

Location

Nemocnice Kyjov, prispevkova organizace, Infekcni oddeleni

Kyjov, 697 01, Czechia

Location

Slezska Nemocnice v Opave, prispevkova organizace

Opava, 74601, Czechia

Location

Policska nemocnice s.r.o.,

Polička, 572 01, Czechia

Location

Fakultni nemocnice v Motole

Prague, 15006, Czechia

Location

Oblastni nemocnice Pribram, a.s.

Pribram I., 26101, Czechia

Location

Interna a kardiologie s.r.o.

Rožnov pod Radhoštěm, 756 61, Czechia

Location

Nemocnice Slany, p.o.

Slaný, 274 01, Czechia

Location

Sarkamed s.r.o.

Slaný, 27401, Czechia

Location

Krajska zdravotni, a.s., Masarykova nemocnice Usti nad Labem

Ústí nad Labem, 401 13, Czechia

Location

Helsinki University Central Hospital

Helsinki, 00029 HUS, Finland

Location

Kokkola Vaccine Research Clinic

Kokkola, 67100, Finland

Location

Oulu Vaccine Research Clinic

Oulu, 90220, Finland

Location

Pori Vaccine Research Clinic

Pori, 28100, Finland

Location

Tampere Vaccine Research Clinic

Tampere, 33100, Finland

Location

Turku Vaccine Research Clinic

Turku, 20520, Finland

Location

CHU DIJON BOURGOGNE- Hopital Francois Mitterrand

Dijon, 21079, France

Location

CIC Vaccinologie Cochin- Pasteur 1417

Paris, 75014, France

Location

Hopital Nord-CHU Saint Etienne

Saint-Priest-en-Jarez, 42270, France

Location

CHRU de Tours- Hopital Bretonneau

Tours, 37044, France

Location

Emovis GmbH

Berlin, 10629, Germany

Location

MECS Cottbus GmbH

Cottbus, 03050, Germany

Location

Diabetologische Gemeinschaftspraxis Dr. Schaper & Dr. Faulmann

Dresden, 01279, Germany

Location

Universitaetsklinikum Essen, Klinik fuer Infektiologie

Essen, 45147, Germany

Location

EUGASTRO GmbH/ Praxis

Leipzig, 04103, Germany

Location

SIBAmed Studienzentrum GmbH & Co.KG

Leipzig, 04103, Germany

Location

Gemeinschaftspraxis Dr. med. Heidrun Taeschner und Dr. med. Susanne Bonigut

Leipzig, 04249, Germany

Location

Universitaetsmedizin Rostock

Rostock, 18057, Germany

Location

Praxis Dr. med. J. Springub/ W. Schwarz

Westerstede, 26655, Germany

Location

Studienzentrum Nordwest

Westerstede, 26655, Germany

Location

Klinikum Wuerzburg Mitte gGmbH

Würzburg, 97070, Germany

Location

Bajai Szent Rokus Korhaz, II Belgyogyaszat

Baja, 6500, Hungary

Location

DRC Kft.

Balatonfüred, 8230, Hungary

Location

Budapesti Szent Ferenc Korhaz, Kardiologiai Rehabilitacios Osztaly

Budapest, 1021, Hungary

Location

Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet, I. Belgyogyaszati Osztaly

Budapest, 1097, Hungary

Location

Orszagos Koranyi Pulmonologiai Intezet, VI. Osztaly

Budapest, 1121, Hungary

Location

Semmelweis Egyetem III. Sz. Belgyogyaszati Klinika

Budapest, 1125, Hungary

Location

ClinTrial Audit Kft., Klinikai Farmakologiai Intezet, Vedooltasi Ambulancia

Debrecen, 4031, Hungary

Location

CRU Hungary Kft.

Encs, 3860, Hungary

Location

Somogy Megyei Kaposi Mor Oktato Korhaz, Infektologiai Osztaly

Kaposvár, 7400, Hungary

Location

Tokai Memorial Hospital

Kasugai, Aichi-ken, 487-0031, Japan

Location

Aichi Medical University Hospital

Nagakute, Aichi-ken, 480-1195, Japan

Location

Daido Clinic

Nagoya, Aichi-ken, 457-8511, Japan

Location

Kamiiida daiichi General Hospital

Nagoya, Aichi-ken, 462-0802, Japan

Location

Iizuka Hospital

Iizuka, Fukuoka, 820-8505, Japan

Location

Seishinkai Inoue Hospital

Itoshima, Fukuoka, 819-1104, Japan

Location

Fukuoka Tokushukai Hospital

Kasuga, Fukuoka, 816-0864, Japan

Location

Kenwakai Otemachi Hospital

Kitakyushu, Fukuoka, 803-8543, Japan

Location

Fukuyama City Hospital

Fukuyama, Hiroshima, 721-8511, Japan

Location

Miyanomori Memorial Hospital

Sapporo, Hokkaido, 064-8570, Japan

Location

Medical Corporation Tokushukai Koga General Hospital

Koga, Ibaraki, 306-0041, Japan

Location

Mito Kyodo General Hospital

Mito, Ibaraki, 310-0015, Japan

Location

Yokosuka Kyosai Hospital

Yokosuka, Kanagawa, 238-8558, Japan

Location

Osaki Citizen Hospital

Ōsaki, Miyagi, 989-6183, Japan

Location

Social Medical Care Corporation Hose-kai Marunouchi Hospital

Matsumoto, Nagano, 390-8601, Japan

Location

Nozaki Tokushukai Hospital

Daitō, Osaka, 547-0074, Japan

Location

Omi Medical Center

Kusatsu, Shiga, 525-8585, Japan

Location

Yaizu City Hospital

Yaizu, Shizuoka, 425-8505, Japan

Location

Juntendo University Hospital

Bunkyo-ku, Tokyo, 113-8431, Japan

Location

Fukuwa Clinic

Chuo-ku, Tokyo, 104-0031, Japan

Location

Nerima General Hospital

Nerima-ku, Tokyo, 176-8530, Japan

Location

Sekino Hospital

Toshima-ku, Tokyo, 171-0014, Japan

Location

Fukui-Ken Saiseikai Hospital

Fukui, 918-8503, Japan

Location

Japanese Red Cross Kumamoto Hospital

Kumamoto, 861-8520, Japan

Location

Saga-Ken Medical Centre Koseikan

Saga, 840-8571, Japan

Location

Hospital Cayetano Heredia

San Martín de Porres, Lima region, 31, Peru

Location

Hospital Nacional Adolfo Guevara Velasco

Cusco, 08002, Peru

Location

Clinica Internacional S.A

Lima, 41, Peru

Location

Centro de Investigaciones Biomédicas - CIBIOM/Clinica Peruano Americana S.A

Trujillo, La Libertad, 13011, Peru

Location

NZOZ Vitamed

Bydgoszcz, 85-079, Poland

Location

Synexus Polska Sp. z o.o Oddzial w Gdansku

Gdansk, 80-382, Poland

Location

Synexus Polska Sp. z o.o. Oddzial w Gdyni

Gdynia, 81-537, Poland

Location

SYNEXUS Polska Sp. z o.o. Oddzial w Katowicach

Katowice, 40-040, Poland

Location

Synexus Polska Sp. z o.o. Oddział w Poznaniu

Poznan, 60-702, Poland

Location

Synexus Polska Sp. z o.o. Oddzial w Warszawie

Warsaw, 01-192, Poland

Location

Synexus Polska Sp. z o.o. Oddzial we Wroclawiu

Wroclaw, 50-381, Poland

Location

Niepubliczny Zaklad Opieki Zdrowotnej Salmed S. C.

Łęczna, 21-010, Poland

Location

Hospital Garcia de Orta

Almada, 2805-267, Portugal

Location

Centro Hospitalar do Baixo Vouga, E.P.E.

Aveiro, 3814-501, Portugal

Location

Hospital de Braga

Braga, 4710-243, Portugal

Location

Hospital Senhora de Oliveira - Guimaraes, E.P.E.

Guimarães, 4835-044, Portugal

Location

Centro Hospitalar Vila Nova de Gaia/Espinho, E.P.E.

Vila Nova de Gaia, 4434-502, Portugal

Location

PULMO-MEDIK s.r.o., Pneumologicko-ftizeologicka ambulancia

Bojnice, 972 01, Slovakia

Location

Medak s.r.o., Gastroenterologicka ambulancia

Bratislava, 851 01, Slovakia

Location

Stalerg, s.r.o.

Košice, 040 22, Slovakia

Location

KM Management spol. s.r.o., Gastroenterologicke a hepatologicke centrum Nitra

Nitra, 949 01, Slovakia

Location

Dionea, s.r.o.

Nové Zámky, 940 01, Slovakia

Location

MEDIPA, s.r.o.

Piešťany, 921 01, Slovakia

Location

MUDr. Viliam Cibik, PhD, s.r.o.

Pruské, 01852, Slovakia

Location

Medilex s.r.o., Interna ambulancia

Rimavská Sobota, 979 01, Slovakia

Location

Plucna ambulancia Hrebenar s.r.o.

Spišská Nová Ves, 052 01, Slovakia

Location

SPAOLO s.r.o., Ambulancia vnutorneho lekarstva

Stará Turá, 916 01, Slovakia

Location

Privatna urologicka ambulancia, s.r.o.

Trenčín, 911 01, Slovakia

Location

MUDr. Zakova, s.r.o.

Trenčín, 91101, Slovakia

Location

Fakutna nemocnica Trnava

Trnava, 917 75, Slovakia

Location

Yonsei University Wonju Severance Christian Hospital

Wŏnju, Gangwon-do, 26426, South Korea

Location

Korea University Ansan Hospital

Ansan, Gyeonggi-do, 15355, South Korea

Location

Asan Medical Center

Songpa-gu, Seoul, 05505, South Korea

Location

Dong-A University Hospital

Busan, 49201, South Korea

Location

Kyungpook National University Hospital

Daegu, 41944, South Korea

Location

The Catholic University of Korea, St. Vincent's Hospital

Gyeonggi-do, 16247, South Korea

Location

Gachon University Gil Medical Center

Incheon, 21565, South Korea

Location

Inha University Hospital

Incheon, 22332, South Korea

Location

Korea University Anam Hospital

Seoul, 02841, South Korea

Location

Hallym University Kangdong Sacred Heart Hospital

Seoul, 05355, South Korea

Location

Samsung Medical Center

Seoul, 06351, South Korea

Location

Hallym University Kangnam Sacred Heart Hospital

Seoul, 07441, South Korea

Location

Korea University Guro Hospital

Seoul, 08308, South Korea

Location

EAP Centelles

Centelles, Barcelona, 08540, Spain

Location

Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, Barcelona, 08907, Spain

Location

Complejo Hospitalario Universitario A Coruna

A Coruña, 15006, Spain

Location

Parc de Salut Mar- Hospital del Mar

Barcelona, 08003, Spain

Location

Hospital Clinic de Barcelona

Barcelona, 08036, Spain

Location

Hospital de la Santa Creu i Sant Pau

Barcelona, 08041, Spain

Location

Hospital Universitario de la Princesa

Madrid, 28006, Spain

Location

Hospital Universitario Gregorio Marañón

Madrid, 28007, Spain

Location

Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain

Location

Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain

Location

Hospital Universitario Virgen Macarena

Seville, 41009, Spain

Location

Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain

Location

Infektionskliniken, Malarsjukhuset

Eskilstuna, 63188, Sweden

Location

Gothia Forum CTC/Sahlgrenska Universitetssjukhuset

Gothenburg, 41345, Sweden

Location

Sahlgrenska Universitetssjukhuset - Ostra Sjukhuset

Gothenburg, 41650, Sweden

Location

Avdelningen for kliniska provningar, S-huset

Örebro, 70362, Sweden

Location

Karolinska Trial Alliance, KTA Prim Sabbatsbergs sjukhus

Stockholm, 11324, Sweden

Location

Kaohsiung Veterans General Hospital

Kaohsiung City, Taiwan (r.o.c.), 81362, Taiwan

Location

Far Eastern Memorial Hospital

New Taipei City, 220, Taiwan

Location

National Taiwan University Hospital

Taipei, 10002, Taiwan

Location

Stockport Nhs Foundation Trust

Stockport, Cheshire, SK27JE, United Kingdom

Location

Fowey River Practice

Fowey, Cornwall, PL23 1DT, United Kingdom

Location

Oak Tree Surgery

Liskeard, Cornwall, PL14 3XA, United Kingdom

Location

The Alverton Practise, St Clare Medical Centre

Penzance, Cornwall, TR183DX, United Kingdom

Location

Rame Group Practice, Rame Medical Ltd.

Torpoint, Cornwall, PL11 2TB, United Kingdom

Location

Royal Devon & Exeter Hospital

Exeter, Devon, EX2 5DW, United Kingdom

Location

Knowle House Surgery

Plymouth, Devon, PL5 3JB, United Kingdom

Location

Layton Medical Centre

Blackpool, Lancashire, FY3 7EN, United Kingdom

Location

University Hospitals of Leicester NHS Trust

Leicester, Leicestershire, LE1 5WW, United Kingdom

Location

NHS Lothian, Western General Hospital

Edinburgh, Midlothian, EH4 2XU, United Kingdom

Location

Heart of England NHS Foundation Trust

Birmingham, WEST Midlands, B9 5SS, United Kingdom

Location

St James University Hospital

Leeds, LS9 7TF, United Kingdom

Location

Newcastle upon Tyne Hospitals NHS Foundation trust

Newcastle upon Tyne, NE1 4LP, United Kingdom

Location

Related Publications (1)

  • Donskey CJ, Dubberke ER, Klein NP, Liles EG, Szymkowiak K, Wilcox MH, Lawrence J, Bouguermouh S, Zhang H, Koury K, Bailey R, Smith HM, Lockhart S, Lamberth E, Kalina WV, Pride MW, Webber C, Anderson AS, Jansen KU, Gruber WC, Kitchin N. CLOVER (CLOstridium difficile Vaccine Efficacy tRial) Study: A Phase 3, Randomized Trial Investigating the Efficacy and Safety of a Detoxified Toxin A/B Vaccine in Adults 50 Years and Older at Increased Risk of Clostridioides difficile Infection. Clin Infect Dis. 2024 Dec 17;79(6):1503-1511. doi: 10.1093/cid/ciae410.

Related Links

MeSH Terms

Conditions

Clostridium Infections

Condition Hierarchy (Ancestors)

Gram-Positive Bacterial InfectionsBacterial InfectionsBacterial Infections and MycosesInfections

Results Point of Contact

Title
Pfizer ClinicalTrials.gov Call Center
Organization
Pfizer Inc.

Study Officials

  • Pfizer CT.gov Call Center

    Pfizer

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 20, 2017

First Posted

March 24, 2017

Study Start

March 29, 2017

Primary Completion

December 21, 2021

Study Completion

December 21, 2021

Last Updated

February 13, 2023

Results First Posted

February 13, 2023

Record last verified: 2023-01

Data Sharing

IPD Sharing
Will share

Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.

More information

Locations