Pituitary Gland Enlargement Was First Diagnosed by Optical Coherence Tomography (OCT)

NCT03087682 | Completed

• 1 other identifier: Pituitary gland enlargement
• Study Type: observational
• Target: 2
• Locations: 1 country
• Sites: 1

Brief Summary

OCT is now an established way to measure the thickness of the Retinal Nerve Fiber Layer (RNFL) in the retina of the eye. The thickness of the RNFL is always a reflection of the number of the RNFs in any particular area of the retina. Each single RNF runs a long course starting from the cell body which is the retinal ganglion cell in the retina and ends in the thalamus of the brain where it relays visual information to other nerve cell in the thalamus. Along this long course RNFs are in close anatomical relationship with the pituitary gland crossing just above this gland about midway along their course. Hence enlargement of this gland can interfere with the RNFs.

Conditions

Pituitary Mass; Diagnoses Disease

Outcome Measures

Primary Outcomes (1)

• Thinning of the retinal nerve fibers (RNF) that are nearest to the pituitary gland, measured in micro-millimeters in OCT, were the first indication of possible enlargement of this gland.

  Pituitary gland enlargement if not treated in time can have devastating effects on vision. Early diagnosis and treatment of this problem can not be over stressed. This study describes thinning of particular RNF in each eye that led to the suspicion of pituitary enlargement and was an early sign of the inferior chiasmal syndrome. Imaging studies were used to validate the suspected result.

  through study completion, an average of one year.

Interventions

Optical Coherence Tomography (OCT) DIAGNOSTIC_TEST

OCT is used to measure thickness (numbers) of retinal nerve fibres in different areas of the retina

Eligibility Criteria

• Age: 15 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Any patient who presents with frequent or persistent headache of unknown reason.

You may qualify if:

• healthy patients with frequent or persistent headache of unknown reasons.

You may not qualify if:

• patients who were previously diagnosed with or treated from pituitary enlargement

Sponsors & Collaborators

• Dr. S.S. Michel Clinic: lead

Study Sites (1)

Dr. S.S. Michel Clinic

Edmonton, Alberta, T5R5W9, Canada

Location

MeSH Terms

Interventions

Tomography, Optical Coherence

Intervention Hierarchy (Ancestors)

Tomography, Optical; Optical Imaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Tomography; Investigative Techniques

Study Officials

• Shawkat S Michel, FRCS Ed

  Dr. S.S. Michel Clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 12, 2017
• First Posted: March 22, 2017
• Study Start: February 1, 2013
• Primary Completion: March 15, 2014
• Study Completion: August 1, 2016
• Last Updated: March 22, 2017

Record last verified: 2017-03

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)