Neuromodulation and Its Therapeutic Potentiality in Different Populations

NCT03084094 | Completed

• 1 other identifier: tDCS in fibromyalgia
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

One of the big challenges faced by researchers who act in rehabilitation science is the capacity to dispose integrative approaches for its utilization in clinical practice. The border profile of a physiotherapy researcher is to be in front of applied research amplification in experimental integrative approaches, involving the study of behavioral and physiological variables. The rehabilitation process transcends the systems physiology and encompasses the cognitive behavioral feature of being adapted to the environment that surround us. It is now known by the scientific rehabilitation community the necessity for evidence based therapies and even more, therapeutic innovation. In both conditions, of health and illness, various options to use integrative approaches are today available in physiotherapy, including behavioral and physiological profiles of the individuals during physical activities, response to stress and in the field of chronic pain. It is in the clinical routine of numerous rehabilitation centers the treatment of diseases that causes pain, being the leading figure in a physiotherapist work process. The innovative study of resources that can alter the pain state of this patients becomes primordial for routine clinical use, low cost and easy to apply. The therapeutic treatment for pain offered by a physiotherapist need new investigative options based in evidences from the association between the neuronal, behavioral and physiological responses where the brain is the central organ of this regulation. In this context, become increasingly more necessary the construction of investigative approaches in the purpose of reaching the clinical practice, in a reduced time lapse, once the great volume of information produced globally does not impact in short or medium term in new therapeutic recommendations. Among the various chronic painful entities, it is presented the fibromyalgia (FM), painful diabetic polyneuropathy and primary dysmenorrhea because of its painful pathogenic complexity and its limited therapeutic against pain in rehabilitation process. The 3 painful entities presents the central nervous system as main participant of neurogenesis and maintenance of the painful state. It is primordial importance that rehabilitation science improve methods of non invasive brain neuromodulation that allows, through excitation or inhibition of specific cortical areas in order to produce pain inhibition, providing a simple and low cost treatment to clinical routine. Technological advances and non invasive techniques to modulate brain function has been developed, among which transcranial direct current stimulation (tDCS) stands out. Basically, electrodes are placed in targeted brain regions that you want to stimulate or inhibit. Posteriorly, is applied a continuous electric current (0,4 - 2 mA) for a 3-20 minutes period, in order to modify cortical excitability. The stimulus of the anodic current increases cortical excitability whereas the stimulus of the cathodic current has an inhibitory effect. Few are the research groups that address the issue of fibromyalgia, painful diabetic polyneuropathy and primary dysmenorrhea and the application of tDCS as research focus, being a border area for rehabilitation science and great potential in clinical use. Preliminary studies associates the use of tDCS with the decrease of painful state, however an approach of physical function and behavioral results needs greater investigation. The purpose of the presented project is to present the tDCS as a new modality in physical rehabilitation for the patient with chronic pain of the 3 entities mentioned above. The study proposal is to present behavioral, social and physical results of tDCS application in this patients, suggesting a better quality of life and functionality of the individual.

Conditions

Fibromyalgia

Keywords

Fibromyalgia; tDCS

Outcome Measures

Primary Outcomes (3)

• Change from Baseline Pain at 2 weeks

  Diary of Pain

  1 week prior to treatment (Baseline) and 1 week during treatment

• Change from Baseline Pain at 5 weeks

  Pressure Pain Threshold and Tolerance by an algometer

  1 week prior to treatment, day 1 of treatment, last day of treatment (day 5), 7 days, 14 days and 21 days after treatment

• Change from Baseline Pain at 5 weeks

  Visual Analogue Scale

  1 week prior to treatment, day 1 of treatment, last day of treatment (day 5), 7 days, 14 days and 21 days after treatment

Secondary Outcomes (4)

• Functional Capacity

  1 week prior to treatment, last day of treatment (day 5),7 days, 14 days and 21 days after treatment

• Mood

  1 week prior to treatment, last day of treatment (day 5),7 days, 14 days and 21 days after treatment

• Anxiety

  1 week prior to treatment, last day of treatment (day 5),7 days, 14 days and 21 days after treatment

• Positive and negative affect

  1 week prior to treatment, last day of treatment (day 5),7 days, 14 days and 21 days after treatment

Study Arms (3)

M1

EXPERIMENTAL

Transcranial direct current Stimulation in primary motor cortex

Device: Transcranial Direct Current Stimulation

DLPFC

EXPERIMENTAL

Transcranial direct current Stimulation in the dorsolateral pre-frontal cortex

Device: Transcranial Direct Current Stimulation

Sham

SHAM COMPARATOR

sham stimulation

Device: Transcranial Direct Current Stimulation

Interventions

Transcranial Direct Current Stimulation DEVICE

Non invasive brain modulation at a 2mA current during 20minutes

DLPFC; M1; Sham

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- Female gender aged from 18 to 65 year old, having a clinical diagnosis of Fibromyalgia given by a rheumatologist.

You may not qualify if:

• Non-regulated psychiatric disorders (bipolar, main depression, schizophrenia)
• Performing other types of treatment during the research
• Performing physical activities

Sponsors & Collaborators

• Universidade Federal do Rio Grande do Norte: lead

Study Sites (1)

Hospital Universitário Onofre Lopes

Natal, Rio Grande do Norte, Brazil

Location

MeSH Terms

Conditions

Fibromyalgia

Interventions

Transcranial Direct Current Stimulation

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Neuromuscular Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 7, 2017
• First Posted: March 20, 2017
• Study Start: October 17, 2016
• Primary Completion: February 28, 2018
• Study Completion: February 28, 2018
• Last Updated: July 6, 2018

Record last verified: 2018-07

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)