Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients

NCT02652988 | Completed

• 1 other identifier: 14-0471
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 2

Brief Summary

In this phase II, randomized, double-blind clinical trial, the investigators intended to evaluate the home-based effect of transcranial direct current stimulation (tDCS) in patients with fibromyalgia. This syndrome affects between 3-5% of the population in an age group 40-60 years also occurring in childhood and old age. Reaches 3.4% of women and 0.5% of men. Fibromyalgia is a chronic widespread pain syndrome in various parts of the body. The neuromodulation techniques have as a principle produce inhibition or cortical arousal. The tDCS is a non-invasive brain stimulation method used to modulate the cortical excitability, using a low intensity direct current (1-2mA) directed to the scalp via the cathode and anode electrodes. The current reaches the cortex, producing hyperpolarization or depolarization of the axonal membrane potential. Evidence has shown that this method is presented as a technique able to alter cortical and subcortical neural networks. This technique has been used to treat psychiatric disorders such as depression, acute mania, bipolar affective disorder, panic, hallucinations, obsessive compulsive disorder, schizophrenia, withdrawal, rehabilitation after stroke, pain syndromes such as neuropathic pain, migraine, pancreatitis pain chronic and fibromyalgia. The tDCS is a low cost technique, with virtually no side effects and which exerts therapeutic effect by neuromodulatory pathways by distinct pathways activated by the drugs. In this scenario falls within the importance of developing this device for home use by fibromyalgia patients, since it is easy to use and thereby enables maintaining the benefit observed in studies performed and supervised frequently used in care centers. The use of tDCS over the long term is not feasible in hospital by patients demands, sometimes every day or more than once a week, removing the patient from their activities, and cost shifting and overload the healthcare system. Therefore, the objective of this study is to evaluate the effect of home-based tDCS in fibromyalgia patients in long-term treatment.

Conditions

Fibromyalgia

Keywords

tDCS; chronic pain; fibromyalgia

Outcome Measures

Primary Outcomes (1)

• Pain level in fibromyalgia patients using home-based tDCS

  Evaluate the level of pain in fibromyalgia patients before and after each home-based tDCS session. We will use numerical pain scale to do that.

  Ffive days per week, during 12 weeks.

Secondary Outcomes (4)

• Serum levels of Brain Derived Neurotrophic Factor (BDNF)

  2 days

• Serum levels of calcium-binding protein B (S100B)

  2 days

• Functional capacity

  2 days

• Catastrophic thinking

  2 days

Study Arms (2)

Active-tDCs

ACTIVE COMPARATOR

17 patients will receive Active-tDCS intervention (2mA, 30 min) at home.

Other: Active-tDCS

Sham-tDCS

SHAM COMPARATOR

17 patients will receive Sham-tDCS intervention (2mA, 30 min) at home.

Other: Sham-tDCS

Interventions

Active-tDCS OTHER

Active home-based tDCS applied at home.

Active-tDCs

Sham-tDCS OTHER

Sham home-based tDCS applied at home.

Sham-tDCS

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• have chronic pain fibromyalgia according to the criteria of the American College of Rheumatology
• Pain unresponsive to analgesics such as paracetamol, acetyl salicylic acid, Ibuprofen, Carisoprodol, Zanaflex (Tizanidine) and Codeine
• Give informed consent to participate after initial evaluation.

You may not qualify if:

• Pregnancy
• Treatment with carbamazepine and gabapentin
• The. Metallic implant in the brain
• Medical devices implanted in the brain
• Alcohol or drug abuse history in the last 6 months
• Suffering from severe depression (with score\> 30 on the Beck Depression Inventory)
• History of neurological disorders
• Unexplained fainting History
• History of head trauma or momentary loss of consciousness (self reported)
• Neurosurgery History
• Decompensated systemic diseases, and chronic inflammatory diseases (lupus, rheumatoid arthritis, renal failure and hepatitis).

Sponsors & Collaborators

• Wolnei Caumo: lead

Study Sites (2)

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90.450-120, Brazil

Location

Wolnei Caumo

Porto Alegre, Rio Grande do Sul, Brazil

Location

Related Publications (24)

• Arnold LM. Biology and therapy of fibromyalgia. New therapies in fibromyalgia. Arthritis Res Ther. 2006;8(4):212. doi: 10.1186/ar1971.

  PMID: 16762044 BACKGROUND

• Ablin J, Fitzcharles MA, Buskila D, Shir Y, Sommer C, Hauser W. Treatment of fibromyalgia syndrome: recommendations of recent evidence-based interdisciplinary guidelines with special emphasis on complementary and alternative therapies. Evid Based Complement Alternat Med. 2013;2013:485272. doi: 10.1155/2013/485272. Epub 2013 Nov 21.

  PMID: 24348701 BACKGROUND

• Bigatti SM, Hernandez AM, Cronan TA, Rand KL. Sleep disturbances in fibromyalgia syndrome: relationship to pain and depression. Arthritis Rheum. 2008 Jul 15;59(7):961-7. doi: 10.1002/art.23828.

  PMID: 18576297 BACKGROUND

• Boggio PS, Rigonatti SP, Ribeiro RB, Myczkowski ML, Nitsche MA, Pascual-Leone A, Fregni F. A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression. Int J Neuropsychopharmacol. 2008 Mar;11(2):249-54. doi: 10.1017/S1461145707007833. Epub 2007 Jun 11.

  PMID: 17559710 BACKGROUND

• Bradley LA, Wohlreich MM, Wang F, Gaynor PJ, Robinson MJ, D'Souza DN, Mease PJ. Pain response profile of patients with fibromyalgia treated with duloxetine. Clin J Pain. 2010 Jul-Aug;26(6):498-504. doi: 10.1097/AJP.0b013e3181dee80e.

  PMID: 20551724 BACKGROUND

• Bymaster FP, Dreshfield-Ahmad LJ, Threlkeld PG, Shaw JL, Thompson L, Nelson DL, Hemrick-Luecke SK, Wong DT. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80. doi: 10.1016/S0893-133X(01)00298-6.

  PMID: 11750180 BACKGROUND

• Burgmer M, Pogatzki-Zahn E, Gaubitz M, Wessoleck E, Heuft G, Pfleiderer B. Altered brain activity during pain processing in fibromyalgia. Neuroimage. 2009 Jan 15;44(2):502-8. doi: 10.1016/j.neuroimage.2008.09.008. Epub 2008 Sep 24.

  PMID: 18848998 BACKGROUND

• Clauw DJ. Fibromyalgia: an overview. Am J Med. 2009 Dec;122(12 Suppl):S3-S13. doi: 10.1016/j.amjmed.2009.09.006.

  PMID: 19962494 BACKGROUND

• Chappell AS, Bradley LA, Wiltse C, Detke MJ, D'Souza DN, Spaeth M. A six-month double-blind, placebo-controlled, randomized clinical trial of duloxetine for the treatment of fibromyalgia. Int J Gen Med. 2008 Nov 30;1:91-102. doi: 10.2147/ijgm.s3979.

  PMID: 20428412 BACKGROUND

• Chen R, Samii A, Canos M, Wassermann EM, Hallett M. Effects of phenytoin on cortical excitability in humans. Neurology. 1997 Sep;49(3):881-3. doi: 10.1212/wnl.49.3.881.

  PMID: 9305361 BACKGROUND

• Fregni F, Gimenes R, Valle AC, Ferreira MJ, Rocha RR, Natalle L, Bravo R, Rigonatti SP, Freedman SD, Nitsche MA, Pascual-Leone A, Boggio PS. A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia. Arthritis Rheum. 2006 Dec;54(12):3988-98. doi: 10.1002/art.22195.

  PMID: 17133529 BACKGROUND

• Fregni F, Boggio PS, Nitsche MA, Marcolin MA, Rigonatti SP, Pascual-Leone A. Treatment of major depression with transcranial direct current stimulation. Bipolar Disord. 2006 Apr;8(2):203-4. doi: 10.1111/j.1399-5618.2006.00291.x. No abstract available.

  PMID: 16542193 BACKGROUND

• Fregni F, Boggio PS, Nitsche M, Pascual-Leone A. Transcranial direct current stimulation. Br J Psychiatry. 2005 May;186:446-7. doi: 10.1192/bjp.186.5.446. No abstract available.

  PMID: 15863752 BACKGROUND

• Giesecke T, Williams DA, Harris RE, Cupps TR, Tian X, Tian TX, Gracely RH, Clauw DJ. Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors. Arthritis Rheum. 2003 Oct;48(10):2916-22. doi: 10.1002/art.11272.

  PMID: 14558098 BACKGROUND

• Harris RE, Clauw DJ. Newer treatments for fibromyalgia syndrome. Ther Clin Risk Manag. 2008 Dec;4(6):1331-42. doi: 10.2147/tcrm.s3396.

  PMID: 19337439 BACKGROUND

• Lindell L, Bergman S, Petersson IF, Jacobsson LT, Herrstrom P. Prevalence of fibromyalgia and chronic widespread pain. Scand J Prim Health Care. 2000 Sep;18(3):149-53. doi: 10.1080/028134300453340.

  PMID: 11097099 BACKGROUND

• Manganotti P, Bongiovanni LG, Zanette G, Turazzini M, Fiaschi A. Cortical excitability in patients after loading doses of lamotrigine: a study with magnetic brain stimulation. Epilepsia. 1999 Mar;40(3):316-21. doi: 10.1111/j.1528-1157.1999.tb00711.x.

  PMID: 10080512 BACKGROUND

• Mease P. Fibromyalgia syndrome: review of clinical presentation, pathogenesis, outcome measures, and treatment. J Rheumatol Suppl. 2005 Aug;75:6-21.

  PMID: 16078356 BACKGROUND

• Moore RA, Cai N, Skljarevski V, Tolle TR. Duloxetine use in chronic painful conditions--individual patient data responder analysis. Eur J Pain. 2014 Jan;18(1):67-75. doi: 10.1002/j.1532-2149.2013.00341.x. Epub 2013 Jun 3.

  PMID: 23733529 BACKGROUND

• Roizenblatt S, Fregni F, Gimenez R, Wetzel T, Rigonatti SP, Tufik S, Boggio PS, Valle AC. Site-specific effects of transcranial direct current stimulation on sleep and pain in fibromyalgia: a randomized, sham-controlled study. Pain Pract. 2007 Dec;7(4):297-306. doi: 10.1111/j.1533-2500.2007.00152.x. Epub 2007 Nov 6.

  PMID: 17986164 BACKGROUND

• Schestatsky P, Stefani LC, Sanches PR, Silva Junior DP, Torres IL, Dall-Agnol L, Balbinot LF, Caumo W. Validation of a Brazilian quantitative sensory testing (QST) device for the diagnosis of small fiber neuropathies. Arq Neuropsiquiatr. 2011 Dec;69(6):943-8. doi: 10.1590/s0004-282x2011000700019.

  PMID: 22297885 BACKGROUND

• Staud R. Treatment of fibromyalgia and its symptoms. Expert Opin Pharmacother. 2007 Aug;8(11):1629-42. doi: 10.1517/14656566.8.11.1629.

  PMID: 17685881 BACKGROUND

• Staud R, Smitherman ML. Peripheral and central sensitization in fibromyalgia: pathogenetic role. Curr Pain Headache Rep. 2002 Aug;6(4):259-66. doi: 10.1007/s11916-002-0046-1.

  PMID: 12095460 BACKGROUND

• Valle A, Roizenblatt S, Botte S, Zaghi S, Riberto M, Tufik S, Boggio PS, Fregni F. Efficacy of anodal transcranial direct current stimulation (tDCS) for the treatment of fibromyalgia: results of a randomized, sham-controlled longitudinal clinical trial. J Pain Manag. 2009;2(3):353-361.

  PMID: 21170277 BACKGROUND

MeSH Terms

Conditions

Fibromyalgia; Chronic Pain

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Neuromuscular Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Wolnei S Calmo, Ph.D

  Hospital de Clínicas de Porto Alegre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Wolnei Caumo, DIRECTOR OF PAIN&NEUROMODULATION LAB

Study Record Dates

• First Submitted: October 28, 2015
• First Posted: January 12, 2016
• Study Start: January 1, 2016
• Primary Completion: May 1, 2018
• Study Completion: June 12, 2018
• Last Updated: August 3, 2018

Record last verified: 2018-08

Locations

BR (2)