A Prospective Cohort Study of Perioperative Covert Stroke and Postoperative Cognitive Dysfunction
PRECISION
1 other identifier
observational
934
1 country
2
Brief Summary
With the development of population aging, the incidence of covert stroke gradually increased. Currently, there is still lack of prospective cohort study with large sample size on the relationship between perioperative covert stroke and postoperative cognitive outcomes. The investigators will perform a prospective cohort study. The aim of the study is to determine whether there is an association between perioperative covert stroke and postoperative cognitive outcomes in elderly patients undergoing noncardiac surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2018
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 10, 2017
CompletedFirst Posted
Study publicly available on registry
March 16, 2017
CompletedStudy Start
First participant enrolled
May 23, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 30, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
August 30, 2023
CompletedAugust 12, 2024
August 1, 2024
4.3 years
March 10, 2017
August 8, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
The incidence of perioperative stroke
Stroke is diagnosed by MRI
Postoperative 1-7 days
Secondary Outcomes (6)
Postoperative cognitive function
1 day before surgery; and 7 days, 3 months, 1 year after surgery
Postoperative delirium
twice a day (from 8:00 to 10:00 and from 18:00 to 20:00) during the first postoperative 5 days
Recovery quality
1 day before surgery; and 7 days, 30 days, 3 months after surgery
The quality of life
1 day before surgery; and 7 days, 30 days, 3 months after surgery
Depression state
1 day before surgery; and 7 days, 30 days, 3 months after surgery
- +1 more secondary outcomes
Study Arms (2)
With stroke
Without stroke
Eligibility Criteria
The population will be selected from patients who schedule to receive elective noncardiac surgery in Beijing Tiantan Hospital and Chinese People's Liberation Army General Hospital.
You may qualify if:
- Eligible patients were aged ≥60 years and scheduled for elective non-cardiac surgery with general anesthesia, with or without concomitant regional analgesia. They were expected to have surgery lasting at least 2 hours of anesthesia and to stay in the hospital at least 2 days thereafter.
You may not qualify if:
- Patients have MRI contraindications, cannot complete the cognitive evaluation, undergo carotid artery surgery or refuse to sign informed consent will be excluded from the trial.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Beijing Tiantan Hospitallead
- Chinese PLA General Hospitalcollaborator
Study Sites (2)
Beijing TianTan Hospital
Beijing, 100070, China
Chinese People's Liberation Army General Hospital
Beijing, China
Related Publications (1)
Cui Q, Wang D, Zeng M, Dong J, Jin H, Hu Z, Zhang Y, Peng Y, Han R. Association of postoperative covert stroke and cognitive dysfunction among elderly patients undergoing non-cardiac surgery: protocol for a prospective cohort study (PRECISION study). BMJ Open. 2020 Jan 6;10(1):e034657. doi: 10.1136/bmjopen-2019-034657.
PMID: 31911527DERIVED
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
March 10, 2017
First Posted
March 16, 2017
Study Start
May 23, 2018
Primary Completion
August 30, 2022
Study Completion
August 30, 2023
Last Updated
August 12, 2024
Record last verified: 2024-08