NCT03081429|Completed
A Prospective Cohort Study of Perioperative Covert Stroke and Postoperative Cognitive Dysfunction
PRECISION
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PRECISION
Sponsor study identifier
observational
934
1 country
2
Study Start
May 23, 2018
Actual (reported)Primary Completion
August 30, 2022
Actual (reported)Study Completion
August 30, 2023
Actual (reported)With the development of population aging, the incidence of covert stroke gradually increased. Currently, there is still lack of prospective cohort study with large sample size on the relationship between perioperative covert stroke and postoperative cognitive outcomes. The investigators will perform a prospective cohort study. The aim of the study is to determine whether there is an association between perioperative covert stroke and postoperative cognitive outcomes in elderly patients undergoing noncardiac surgery.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 30, 2023
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 10, 2017
Actual (reported)March 16, 2017
Actual (reported)May 23, 2018
Actual (reported)August 30, 2022
Actual (reported)August 30, 2023
Actual (reported)The incidence of perioperative stroke
Stroke is diagnosed by MRI
Postoperative 1-7 days
Postoperative cognitive function
1 day before surgery; and 7 days, 3 months, 1 year after surgery
Postoperative delirium
twice a day (from 8:00 to 10:00 and from 18:00 to 20:00) during the first postoperative 5 days
Recovery quality
1 day before surgery; and 7 days, 30 days, 3 months after surgery
The quality of life
1 day before surgery; and 7 days, 30 days, 3 months after surgery
Depression state
1 day before surgery; and 7 days, 30 days, 3 months after surgery
The population will be selected from patients who schedule to receive elective noncardiac surgery in Beijing Tiantan Hospital and Chinese People's Liberation Army General Hospital.
Beijing TianTan Hospital
Beijing, 100070, China
Chinese People's Liberation Army General Hospital
Beijing, China
Cui Q, Wang D, Zeng M, Dong J, Jin H, Hu Z, Zhang Y, Peng Y, Han R. Association of postoperative covert stroke and cognitive dysfunction among elderly patients undergoing non-cardiac surgery: protocol for a prospective cohort study (PRECISION study). BMJ Open. 2020 Jan 6;10(1):e034657. doi: 10.1136/bmjopen-2019-034657.
934 participants (actual enrollment reported by the registry).
First Submitted
March 10, 2017
First Posted
March 16, 2017
Study Start
May 23, 2018
Actual (reported)The Effect on the Older's Cognition of Dual-loop Target Controlled Infusion Guided by Narcotrend Index
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Primary Completion
August 30, 2022
Actual (reported)Study Completion
August 30, 2023
Actual (reported)Last Updated
August 12, 2024
Record last verified: 2024-08
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Source: ClinicalTrials.gov.
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