NCT03072342|Completed
PERIODONTITIS AND VASCULAR DYSFUNCTION
INTENSIVE TREATMENT FOR PERIODONTAL DISEASE: A MODEL OF AND THERAPY OF INFLAMMATORY VASCULAR DYSFUNCTION
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INTENSIVE TREATMENT FOR PERIODONTAL DISEASE: A MODEL OF AND THERAPY OF INFLAMMATORY VASCULAR DYSFUNCTION
Sponsor study identifier
interventional
190
1 country
1
Study Start
April 16, 2013
Actual (reported)Primary Completion
March 30, 2020
Actual (reported)Study Completion
March 30, 2020
Actual (reported)The investigators wish to assess whether intensive periodontal therapy will reduce the burden of chronic periodontal disease and will cause regression or prevent progression of atherosclerosis assessed by a surrogate end-point (carotid intima-media thickness) at 24 months compared to control periodontal therapy.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 30, 2020
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 16, 2013
Actual (reported)March 1, 2017
Actual (reported)March 7, 2017
Actual (reported)March 30, 2020
Actual (reported)March 30, 2020
Actual (reported)Common Carotid Intima-media Thickness (cIMT)
Assess whether intensive periodontal therapy will cause regression or prevent progression of atherosclerosis assessed by carotid intima-media thickness at 24 months compared to standard periodontal therapy.
cIMT will be assessed at Baseline, 12 and 24 months after periodontal treatment
Brachial artery Flow-mediated dilatation (FMD)
FMD will be assessed at baseline, 24 hours and 1 week after periodontal treatment
Pulse-wave velocity (PWV)
PWV will be assessed at baseline, 2, 6, 12, 18 and 24 months following periodontal treatment
Brachial artery Flow-mediated dilatation (FMD)
FMD will be assessed at baseline, 2 , 6 , 12 , 18 and 24 months following periodontal treatment
Blood inflammatory markers
Inflammatory mediators profile will be assessed at baseline, 2, 6, 12, 18 and 24 months following periodontal treatment
Oxidative stress
Oxidative stress profile will be assessed at baseline, 2, 6, 12, 18 and 24 months following periodontal treatment
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
UCL-Eastman Dental Institute
London, WC1X 8LD, United Kingdom
Orlandi M, Masi S, Bhowruth D, Leira Y, Georgiopoulos G, Yellon D, Hingorani A, Chiesa ST, Hausenloy DJ, Deanfield J, D'Aiuto F. Remote Ischemic Preconditioning Protects Against Endothelial Dysfunction in a Human Model of Systemic Inflammation: A Randomized Clinical Trial. Arterioscler Thromb Vasc Biol. 2021 Aug;41(8):e417-e426. doi: 10.1161/ATVBAHA.121.316388. Epub 2021 Jun 10.
John Deanfield, MD
UCL
190 participants (actual enrollment reported by the registry).
First Submitted
March 1, 2017
First Posted
March 7, 2017
Study Start
April 16, 2013
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
March 30, 2020
Actual (reported)Study Completion
March 30, 2020
Actual (reported)Last Updated
January 25, 2021
Record last verified: 2020-02
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Source: ClinicalTrials.gov.
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